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Official Description

Intradermal cancer immunotherapy; each additional injection (List separately in addition to code for primary procedure)

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

Intradermal cancer immunotherapy is a treatment approach that leverages the body's immune system to combat cancer. Unlike traditional chemotherapy, which directly targets and kills cancer cells, immunotherapy aims to enhance and activate the immune response to identify and destroy cancerous cells. This method utilizes the body's natural defenses, making it a promising avenue for cancer treatment. However, it is important to note that immunotherapy can lead to significant side effects in some patients, including cytokine release syndrome, vascular leak syndrome, and autoimmune reactions, which can be serious or even fatal. The administration of immunotherapy through injections allows for a more localized treatment strategy, targeting tumors more effectively while reducing the systemic toxicity often associated with broader treatment methods. Intradermal injections, in particular, are advantageous due to the higher concentration of dendritic cells in the dermis. These cells play a crucial role in capturing antigens and stimulating T-cells, thereby enhancing the immune response against tumors. For billing purposes, the CPT® code 0708T is used to report the preparation and initial intradermal injection of an immunotherapy treatment, while CPT® code 0709T is designated for each additional injection administered in the course of treatment.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The indications for intradermal cancer immunotherapy include the following:

  • Cancer Treatment This procedure is performed as part of a treatment regimen for various types of cancer, where the goal is to enhance the immune system's ability to recognize and attack cancer cells.
  • Immunotherapy Support It is indicated for patients who may benefit from an immunotherapy approach, particularly when traditional therapies have been ineffective or are not suitable.

2. Procedure

The procedure for administering intradermal cancer immunotherapy involves several key steps:

  • Preparation of the Injection Site The healthcare provider begins by selecting an appropriate site for the injection, typically in the dermal layer of the skin. The area is cleaned and sterilized to minimize the risk of infection.
  • Preparation of the Immunotherapy Agent The immunotherapy agent is prepared according to the manufacturer's instructions. This may involve reconstituting a powdered medication or drawing up a pre-prepared solution into a syringe.
  • Administration of the Injection The provider then administers the intradermal injection, ensuring that the needle is inserted at the correct angle to deliver the agent into the dermis. This step is crucial for maximizing the immune response.
  • Monitoring the Patient After the injection, the patient is monitored for any immediate adverse reactions or side effects. This may include observing for signs of an allergic reaction or other complications.

3. Post-Procedure

Post-procedure care for patients receiving intradermal cancer immunotherapy includes monitoring for side effects and providing instructions for care at the injection site. Patients may experience localized reactions such as redness, swelling, or discomfort at the injection site, which should be managed with appropriate topical treatments if necessary. It is also important for patients to report any unusual symptoms or severe side effects to their healthcare provider promptly. Follow-up appointments may be scheduled to assess the effectiveness of the treatment and to determine if additional injections are needed.

Short Descr ID CA IMMNTX EACH ADDL NJX
Medium Descr INTRADERMAL CANCER IMMNTX EACH ADDL INJECTION
Long Descr Intradermal cancer immunotherapy; each additional injection (List separately in addition to code for primary procedure)
Status Code Carriers Price the Code
Global Days ZZZ - Code Related to Another Service
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Non-Covered Service, not paid under OPPS
Berenson-Eggers TOS (BETOS) none
MUE 2

This is an add-on code that must be used in conjunction with one of these primary codes.

0708T MPFS Status: Carrier Priced APC E1 Intradermal cancer immunotherapy; preparation and initial injection
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
Date
Action
Notes
2022-01-01 Added Code added
Code
Description
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