CPT® Code 0732T

1. Indications

The immunotherapy administration with electroporation, intramuscular (CPT® Code 0732T) is indicated for the treatment of specific diseases where enhanced immune response is necessary. The following conditions are explicitly mentioned as suitable for this procedure:

• Cancer - This procedure is utilized to stimulate the immune system to recognize and attack cancer cells more effectively.
• HIV - The technique aims to improve the immune response against the HIV virus, potentially aiding in the management of the disease.

2. Procedure

The procedure for immunotherapy administration with electroporation involves several critical steps to ensure effective delivery of the treatment. Each step is designed to maximize the therapeutic benefits while maintaining patient safety.

• Step 1: Preparation of the Device - The process begins with the assembly of the handheld needle array device. A drug cartridge containing the DNA-based vaccine is loaded into the device, and the needle depth is adjusted to an appropriate level based on the treatment site and patient anatomy. This preparation is crucial for ensuring that the drug is delivered effectively to the target tissue.
• Step 2: Setting Electroporation Parameters - Prior to administration, the physician sets the electroporation parameters, which include the strength, duration, and interval of the electrical pulses. These settings are tailored to optimize the transfer of the vaccine into the cells while minimizing any potential tissue damage. The careful calibration of these parameters is essential for achieving the desired immunological response.
• Step 3: Positioning the Patient - The patient is positioned comfortably, and the physician stabilizes the limb at the treatment site to prevent any movement during the procedure. This stabilization is important to ensure accurate delivery of the vaccine and effective application of the electroporation.
• Step 4: Administration of the Treatment - Once the patient is ready, the needle array device is applied to the treatment site. The drug is injected intramuscularly, followed by the application of electropulses. This combination of drug delivery and electroporation is designed to enhance cellular uptake of the vaccine.
• Step 5: Post-Procedure Handling - After the administration is complete, the single-use needle array is discarded in accordance with safety protocols. The handset is then placed in the docking station, ensuring that all equipment is properly stored and ready for future use.

3. Post-Procedure

Following the immunotherapy administration with electroporation, intramuscular, patients may be monitored for any immediate reactions or side effects. While specific post-procedure care is not detailed in the provided data, standard practices typically include observing the injection site for signs of infection or adverse reactions. Patients may also receive instructions regarding any follow-up appointments or additional treatments as part of their overall care plan. It is essential for healthcare providers to document the procedure accurately and ensure that all safety and hygiene protocols are followed to maintain compliance and patient safety.