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Official Description

Digitization of glass microscope slides for immunohistochemistry or immunocytochemistry, per specimen, each multiplex antibody stain procedure (List separately in addition to code for primary procedure)

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

Digitization of glass microscope slides refers to the process of converting physical glass slides into a digital format. This procedure is specifically utilized for immunohistochemistry or immunocytochemistry, which are techniques used to identify specific antigens in tissue samples or cultured cells. The digitization process involves scanning the glass slides, capturing high-resolution images that are then stored either on a local computer server or in a cloud-based archive. This digital transformation facilitates further examination of the slides, allowing pathologists to analyze the images remotely or utilize computer algorithms for diagnostic purposes. The information obtained from these digital images can be managed and interpreted within an increasingly image-based medical environment. The procedure is particularly relevant when special stain slides are prepared, as these slides are scanned into a digital slide imaging system. The antibody stains used in immunohistochemistry or immunocytochemistry are essential for detecting specific markers that are indicative of various types of cancers, particularly those where certain tumor antigens are expressed. For instance, the digitization process can be reported using CPT® Code 0762T when it is performed concurrently with a multiplex antibody stain procedure, such as an AMACR/P504S or a P63/HMWCK/AMACR cocktail stain for prostate cancer. This allows for a comprehensive pathological diagnosis, with the interpretation and report being distinct from traditional direct visualization methods through a microscope.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The digitization of glass microscope slides for immunohistochemistry or immunocytochemistry is indicated for the following:

  • Pathological Diagnosis This procedure is performed to assist in diagnosing and classifying various types of cancers by identifying specific tumor antigens expressed in tissue samples or cultured cells.
  • Remote Examination It allows pathologists to examine slides remotely, enhancing accessibility and collaboration in diagnostic processes.
  • Utilization of Computer Algorithms The digitized images can be analyzed using computer algorithms, which can aid in providing a more accurate pathologic diagnosis.

2. Procedure

The procedure for digitization of glass microscope slides involves several key steps:

  • Preparation of Slides Initially, the glass microscope slides are prepared with special stains that are necessary for immunohistochemistry or immunocytochemistry. This preparation is crucial as it ensures that the specific markers can be effectively identified in the tissue or cultured cells.
  • Scanning of Slides Once the slides are prepared, they are placed into a digital slide imaging system. The system scans the slides, capturing high-resolution images that represent the stained specimens. This scanning process is essential for creating a digital record of the slides.
  • Storage of Digital Images After scanning, the digital images are stored on a local computer server or within a cloud-based archive. This storage allows for easy access and management of the images for future examination and interpretation.
  • Integration with Diagnostic Processes The digitized images can then be utilized for further analysis, either by pathologists or through automated systems, to provide a comprehensive pathological diagnosis. This step is critical as it distinguishes the digital interpretation from traditional methods of direct visualization through a microscope.

3. Post-Procedure

Post-procedure care for the digitization of glass microscope slides primarily involves ensuring that the digital images are securely stored and easily accessible for future use. Pathologists may review the digitized slides for diagnostic purposes, and the information obtained can be integrated into patient records. Additionally, the digital format allows for ongoing analysis and interpretation, which can enhance the accuracy of diagnoses over time. There are no specific recovery considerations for this procedure, as it is a technical process rather than an invasive medical intervention.

Short Descr DGTZ GLS MCRSCP SL IMM EA M
Medium Descr DGTZ GLS MCRSCP SLD IMHCHEM/IMCTCHM EA MULT ANTB
Long Descr Digitization of glass microscope slides for immunohistochemistry or immunocytochemistry, per specimen, each multiplex antibody stain procedure (List separately in addition to code for primary procedure)
Status Code Carriers Price the Code
Global Days ZZZ - Code Related to Another Service
PC/TC Indicator (26, TC) 3 - Technical Component Only Code
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
Berenson-Eggers TOS (BETOS) none
MUE 6

This is an add-on code that must be used in conjunction with one of these primary codes.

88344 MPFS Status: Active Code APC Q1 Immunohistochemistry or immunocytochemistry, per specimen; each multiplex antibody stain procedure
Date
Action
Notes
2023-01-01 Added Code added.
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