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Official Description

Biopsy, muscle; deep

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 20205 refers to a deep muscle biopsy, which is a specific type of incisional biopsy performed on muscle tissue that is located deeper beneath the surface. This procedure is essential for obtaining a tissue sample from the muscle to facilitate the diagnosis of various muscle-related diseases. Conditions such as muscular dystrophy, myasthenia gravis, polymyositis, dermatomyositis, amyotrophic lateral sclerosis (ALS), Friedreich's ataxia, and infections caused by parasites like trichinosis or toxoplasmosis can be evaluated through this biopsy. The process begins with the careful cleansing of the planned biopsy site to minimize the risk of infection. Following this, a surgical incision is made in the muscle to access the deeper tissue, allowing for the collection of a sample. This sample is then sent for pathology examination, which is reported separately. It is important to note that CPT® Code 20205 is specifically designated for cases where a deeper incision and tissue dissection are necessary, distinguishing it from the related code 20200, which is used for superficial muscle biopsies.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The deep muscle biopsy, represented by CPT® Code 20205, is indicated for the evaluation of various muscle disorders and conditions. The following are the specific indications for performing this procedure:

  • Muscular Dystrophy - A group of genetic diseases characterized by progressive weakness and degeneration of the skeletal muscles.
  • Myasthenia Gravis - An autoimmune disorder that leads to varying degrees of skeletal muscle weakness due to a breakdown in communication between nerves and muscles.
  • Polymyositis - An inflammatory disease causing muscle weakness, particularly affecting the proximal muscles.
  • Dermatomyositis - An inflammatory condition characterized by muscle weakness and a distinctive skin rash.
  • Amyotrophic Lateral Sclerosis (ALS) - A progressive neurodegenerative disease affecting nerve cells in the brain and spinal cord, leading to loss of muscle control.
  • Friedreich's Ataxia - A hereditary degenerative disease that affects the nervous system and the heart, leading to progressive loss of coordination and muscle strength.
  • Trichinosis - A parasitic disease caused by eating raw or undercooked meat infected with larvae of the Trichinella worm, which can invade muscle tissue.
  • Toxoplasmosis - An infection caused by the Toxoplasma gondii parasite, which can affect muscle tissue among other organs.

2. Procedure

The procedure for a deep muscle biopsy involves several critical steps to ensure the successful collection of a tissue sample. The following outlines the procedural steps:

  • Step 1: Site Preparation - The first step involves the careful cleansing of the planned biopsy site. This is crucial to reduce the risk of infection and ensure a sterile environment for the procedure.
  • Step 2: Incision - After the site has been prepared, a surgical incision is made in the muscle. The depth and location of the incision are determined based on the specific area of muscle tissue that needs to be sampled.
  • Step 3: Tissue Sample Collection - Once the incision is made, the physician carefully dissects the muscle tissue to obtain a sample. This sample must be large enough to provide adequate material for pathological examination.
  • Step 4: Sample Handling - After the tissue sample is collected, it is placed in appropriate containers and sent for pathology examination. This examination is critical for diagnosing the underlying muscle condition.

3. Post-Procedure

Post-procedure care following a deep muscle biopsy is essential for ensuring proper healing and monitoring for any complications. Patients are typically advised to rest the affected area and may be given specific instructions regarding pain management and wound care. It is important to monitor the biopsy site for signs of infection, such as increased redness, swelling, or discharge. Follow-up appointments may be scheduled to review the pathology results and discuss any further treatment options based on the findings. Recovery time can vary depending on the individual and the extent of the procedure, but patients are generally encouraged to avoid strenuous activities until cleared by their healthcare provider.

Short Descr DEEP MUSCLE BIOPSY
Medium Descr BIOPSY MUSCLE DEEP
Long Descr Biopsy, muscle; deep
Status Code Active Code
Global Days 000 - Endoscopic or Minor Procedure
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Hospital Part B services paid through a comprehensive APC
ASC Payment Indicator Surgical procedure on ASC list in CY 2007; payment based on OPPS relative payment weight.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P5B - Ambulatory procedures - musculoskeletal
MUE 3
CCS Clinical Classification 159 - Other diagnostic procedures on musculoskeletal system
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
GC This service has been performed in part by a resident under the direction of a teaching physician
RT Right side (used to identify procedures performed on the right side of the body)
SG Ambulatory surgical center (asc) facility service
LT Left side (used to identify procedures performed on the left side of the body)
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
22 Increased procedural services: when the work required to provide a service is substantially greater than typically required, it may be identified by adding modifier 22 to the usual procedure code. documentation must support the substantial additional work and the reason for the additional work (ie, increased intensity, time, technical difficulty of procedure, severity of patient's condition, physical and mental effort required). note: this modifier should not be appended to an e/m service.
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
80 Assistant surgeon: surgical assistant services may be identified by adding modifier 80 to the usual procedure number(s).
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
CR Catastrophe/disaster related
ET Emergency services
F6 Right hand, second digit
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
PT Colorectal cancer screening test; converted to diagnostic test or other procedure
T9 Right foot, fifth digit
UD Medicaid level of care 13, as defined by each state
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
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