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Official Description

Biopsy, soft tissue of forearm and/or wrist; deep (subfascial or intramuscular)

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The procedure described by CPT® Code 25066 refers to a biopsy of the soft tissue located in the forearm and/or wrist, specifically targeting deeper structures such as those beneath the fascia or within the muscle itself. A soft tissue biopsy is a surgical procedure that involves the removal of a small sample of tissue for diagnostic purposes. The term "soft tissue" encompasses various types of biological materials, including muscles, tendons, fat, blood vessels, lymph vessels, nerves, and the connective tissues surrounding joints. This procedure is typically performed when there is a need to investigate abnormalities or lesions that may not be accessible through superficial methods. Prior to the biopsy, anesthesia—whether local, regional, or general—is administered to ensure patient comfort during the procedure. The area of the skin over the biopsy site is meticulously cleansed to minimize the risk of infection. An incision is then made, allowing the surgeon to carefully dissect through the layers of tissue down to the targeted mass or lesion, while taking precautions to avoid damaging any nearby blood vessels or nerves. Once the tissue sample is obtained, it is sent to a laboratory for histological evaluation, which is reported separately. After the sample is collected, the incision is closed using sutures to promote proper healing. It is important to note that CPT® Code 25066 is specifically designated for deeper biopsies that require more extensive dissection compared to superficial biopsies, which are coded under CPT® Code 25065.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The biopsy of soft tissue in the forearm and/or wrist, as described by CPT® Code 25066, is indicated for various clinical scenarios where deeper tissue evaluation is necessary. The following conditions may warrant this procedure:

  • Suspicious Mass or Lesion A palpable mass or lesion in the forearm or wrist that requires histological examination to determine its nature, whether benign or malignant.
  • Unexplained Pain or Swelling Persistent pain or swelling in the forearm or wrist region that does not respond to conservative treatment and necessitates further investigation.
  • Infectious Process Suspected infections involving deeper soft tissues that may require tissue sampling to identify the causative organism.
  • Inflammatory Conditions Conditions such as autoimmune diseases that may affect the soft tissues and require biopsy for diagnosis and management.

2. Procedure

The procedure for performing a deep soft tissue biopsy of the forearm and/or wrist involves several critical steps to ensure accuracy and patient safety. The following procedural steps are outlined:

  • Step 1: Anesthesia Administration Prior to the biopsy, appropriate anesthesia is administered based on the depth and location of the biopsy site. This may include local anesthesia to numb the area, regional anesthesia to block sensation in a larger area, or general anesthesia for more extensive procedures.
  • Step 2: Skin Preparation The skin over the biopsy site is thoroughly cleansed using antiseptic solutions to reduce the risk of infection. This step is crucial for maintaining a sterile environment during the procedure.
  • Step 3: Incision and Dissection A careful incision is made through the skin, and the surgeon dissects through the layers of soft tissue down to the targeted mass or lesion. During this process, special attention is given to protect surrounding blood vessels and nerves to prevent complications.
  • Step 4: Tissue Sample Collection Once the mass or lesion is reached, a tissue sample is excised for further analysis. This sample is critical for histological evaluation, which will help in diagnosing the underlying condition.
  • Step 5: Closure of Incision After the tissue sample is obtained, the incision is closed using sutures. Proper closure is essential for promoting healing and minimizing scarring.

3. Post-Procedure

After the biopsy procedure, patients are typically monitored for any immediate complications, such as excessive bleeding or infection. Instructions for post-procedure care are provided, which may include keeping the biopsy site clean and dry, monitoring for signs of infection, and managing pain with prescribed medications. Patients are advised to avoid strenuous activities that may strain the biopsy site during the initial healing period. Follow-up appointments may be scheduled to discuss the results of the histological evaluation and to determine any further necessary treatment based on the findings.

Short Descr BIOPSY FOREARM SOFT TISSUES
Medium Descr BIOPSY SOFT TISSUE FOREARM&/WRIST DEEP
Long Descr Biopsy, soft tissue of forearm and/or wrist; deep (subfascial or intramuscular)
Status Code Active Code
Global Days 090 - Major Surgery
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 1 - 150% payment adjustment for bilateral procedures applies.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Hospital Part B services paid through a comprehensive APC
ASC Payment Indicator Surgical procedure on ASC list in CY 2007; payment based on OPPS relative payment weight.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P5B - Ambulatory procedures - musculoskeletal
MUE 2
CCS Clinical Classification 159 - Other diagnostic procedures on musculoskeletal system
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
RT Right side (used to identify procedures performed on the right side of the body)
LT Left side (used to identify procedures performed on the left side of the body)
GC This service has been performed in part by a resident under the direction of a teaching physician
50 Bilateral procedure: unless otherwise identified in the listings, bilateral procedures that are performed at the same session, should be identified by adding modifier 50 to the appropriate 5 digit code. note: this modifier should not be appended to designated "add-on" codes (see appendix d).
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
80 Assistant surgeon: surgical assistant services may be identified by adding modifier 80 to the usual procedure number(s).
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
F3 Left hand, fourth digit
F5 Right hand, thumb
F6 Right hand, second digit
F7 Right hand, third digit
F8 Right hand, fourth digit
FA Left hand, thumb
SG Ambulatory surgical center (asc) facility service
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
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