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Official Description

Injection procedure; radioactive tracer for identification of sentinel node

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

An injection procedure is conducted to identify the sentinel node, which is a critical component in lymph node mapping. The sentinel node is the first lymph node that receives lymphatic drainage from a tumor site, making it essential for determining the spread of cancer. This procedure utilizes a combination of a weak radioactive tracer, specifically technetium-labeled sulfur colloid (technetium-99), and a blue dye known as isosulfan blue. The radioactive tracer is injected directly into the tumor site or the tumor bed, allowing it to travel through the lymphatic system to the sentinel node. The identification of the sentinel node is facilitated by a hand-held probe that detects the radioactive signal emitted by the tracer. The process of tracking the radioactive dye can take anywhere from 45 minutes to 8 hours. Following the detection of the sentinel node, the blue dye is injected, which stains the lymph tissue a bright blue, enhancing visibility during subsequent surgical procedures. Once both dyes have reached the sentinel node, a lymph node biopsy can be performed, which is reported separately. This procedure is crucial for staging cancer and planning appropriate treatment strategies.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The injection procedure for identifying the sentinel node is indicated in various clinical scenarios, particularly in the context of cancer treatment and staging. The following conditions may warrant this procedure:

  • Breast Cancer - This procedure is commonly performed in patients with breast cancer to assess the spread of the disease to the lymphatic system.
  • Melanoma - Patients diagnosed with melanoma may undergo this procedure to determine if cancer has spread to the sentinel lymph nodes.
  • Other Solid Tumors - The procedure may also be indicated for other solid tumors where lymphatic drainage patterns are critical for staging and treatment planning.

2. Procedure

The procedure for identifying the sentinel node involves several key steps that ensure accurate localization of the lymph node. Each step is crucial for the successful identification and subsequent biopsy of the sentinel node.

  • Step 1: Injection of Radioactive Tracer - The first step involves the injection of a weak radioactive tracer, specifically technetium-labeled sulfur colloid (technetium-99), directly into the tumor site or tumor bed. This tracer is designed to travel through the lymphatic system to the sentinel node, allowing for its identification.
  • Step 2: Detection of the Sentinel Node - After the radioactive tracer is injected, a hand-held probe is used to detect the radioactive signal emitted by the tracer as it reaches the sentinel node. This detection process is critical for confirming the location of the sentinel node.
  • Step 3: Injection of Blue Dye - Following the identification of the sentinel node with the radioactive tracer, an injection of isosulfan blue dye is administered. This dye stains the lymph tissue bright blue, providing visual confirmation of the sentinel node's location during surgical procedures.
  • Step 4: Timing and Monitoring - The entire process of tracking the radioactive dye can take between 45 minutes to 8 hours. During this time, healthcare professionals monitor the progress of the tracer to ensure accurate identification of the sentinel node.
  • Step 5: Lymph Node Biopsy - Once both the radioactive and blue dyes have reached the sentinel node, a separately reportable lymph node biopsy is performed. This biopsy is essential for assessing the presence of cancer cells in the lymphatic system.

3. Post-Procedure

After the injection procedure for sentinel node identification, patients may experience some localized discomfort or swelling at the injection site. It is important for healthcare providers to monitor the patient for any adverse reactions to the dyes used. Patients are typically advised to follow up with their healthcare provider to discuss the results of the lymph node biopsy and any further treatment options that may be necessary based on the findings. Additionally, the timing of any subsequent surgical interventions or treatments will be determined based on the results of the biopsy and the overall clinical picture.

Short Descr RA TRACER ID OF SENTINL NODE
Medium Descr INJ RADIOACTIVE TRACER FOR ID OF SENTINEL NODE
Long Descr Injection procedure; radioactive tracer for identification of sentinel node
Status Code Active Code
Global Days 000 - Endoscopic or Minor Procedure
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 1 - 150% payment adjustment for bilateral procedures applies.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator STV-Packaged Codes
ASC Payment Indicator Packaged service/item; no separate payment made.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) I1F - Standard imaging - other
MUE 1
CCS Clinical Classification 226 - Other diagnostic radiology and related techniques
LT Left side (used to identify procedures performed on the left side of the body)
RT Right side (used to identify procedures performed on the right side of the body)
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
GC This service has been performed in part by a resident under the direction of a teaching physician
MG The order for this service does not have applicable appropriate use criteria in the qualified clinical decision support mechanism consulted by the ordering professional
50 Bilateral procedure: unless otherwise identified in the listings, bilateral procedures that are performed at the same session, should be identified by adding modifier 50 to the appropriate 5 digit code. note: this modifier should not be appended to designated "add-on" codes (see appendix d).
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
22 Increased procedural services: when the work required to provide a service is substantially greater than typically required, it may be identified by adding modifier 22 to the usual procedure code. documentation must support the substantial additional work and the reason for the additional work (ie, increased intensity, time, technical difficulty of procedure, severity of patient's condition, physical and mental effort required). note: this modifier should not be appended to an e/m service.
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
80 Assistant surgeon: surgical assistant services may be identified by adding modifier 80 to the usual procedure number(s).
81 Minimum assistant surgeon: minimum surgical assistant services are identified by adding modifier 81 to the usual procedure number.
82 Assistant surgeon (when qualified resident surgeon not available): the unavailability of a qualified resident surgeon is a prerequisite for use of modifier 82 appended to the usual procedure code number(s).
AG Primary physician
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
CR Catastrophe/disaster related
GW Service not related to the hospice patient's terminal condition
MH Unknown if ordering professional consulted a clinical decision support mechanism for this service, related information was not provided to the furnishing professional or provider
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
SG Ambulatory surgical center (asc) facility service
UA Medicaid level of care 10, as defined by each state
X3 Episodic/broad services: for reporting services by clinicians who have broad responsibility for the comprehensive needs of the patient that is limited to a defined period and circumstance such as a hospitalization; reporting clinician service examples include but are not limited to the hospitalist's services rendered providing comprehensive and general care to a patient while admitted to the hospital
XP Separate practitioner, a service that is distinct because it was performed by a different practitioner
Date
Action
Notes
2012-01-01 Changed Description Changed
1999-01-01 Added First appearance in code book in 1999.
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