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Official Description

Esophagoscopy, flexible, transoral; with directed submucosal injection(s), any substance

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The procedure described by CPT® Code 43201 refers to a flexible esophagoscopy performed transorally, which involves the use of a flexible endoscope to visualize the esophagus. This diagnostic procedure allows for a thorough examination of the esophagus, including the velopharyngeal closure, base of the tongue, and hypopharynx. During the esophagoscopy, the physician observes vocal cord motion and evaluates the pharyngeal musculature. The endoscope is introduced through the mouth and carefully advanced into the esophagus, reaching the gastroesophageal junction. Any abnormalities encountered during the procedure are meticulously noted. In addition to visual examination, the procedure may involve the collection of tissue specimens through brushing or washing techniques. In the context of CPT® Code 43201, the procedure is further enhanced by the inclusion of directed submucosal injection(s) of any substance. This step is crucial for various therapeutic and diagnostic purposes. Common substances used for injection include India ink, which is utilized for tattooing lesions to aid in their identification prior to excision, as well as saline, epinephrine, and corticosteroids. Saline or epinephrine injections serve to separate the mucosal layer from the muscle layer of the esophagus, facilitating the elevation of lesions for excision. Additionally, botulinum toxin is specifically indicated for the treatment of esophageal achalasia, where it is injected into the esophageal sphincter. The procedure may involve one or more submucosal injections, which are performed prior to any separately reportable lesion excision, thereby enhancing the overall effectiveness of the esophagoscopy.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The procedure described by CPT® Code 43201 is indicated for various conditions that necessitate a detailed examination and potential treatment of the esophagus. The following are explicitly provided indications for performing this procedure:

  • Esophageal Lesions - The procedure is indicated for the identification and treatment of lesions within the esophagus, which may require further intervention.
  • Esophageal Achalasia - This condition, characterized by difficulty in swallowing due to the inability of the esophageal sphincter to relax, may be treated with botulinum toxin injections during the procedure.
  • Evaluation of Abnormalities - The esophagoscopy allows for the assessment of any abnormalities noted during the examination of the esophagus, including structural or functional issues.

2. Procedure

The procedure for CPT® Code 43201 involves several critical steps that ensure a comprehensive evaluation and treatment of the esophagus. The following procedural steps are outlined:

  • Step 1: Introduction of the Endoscope - The flexible endoscope is introduced through the patient's mouth and carefully advanced into the esophagus. This initial step is crucial for gaining access to the esophageal lumen for examination.
  • Step 2: Examination of the Esophagus - As the endoscope is advanced, the physician examines the velopharyngeal closure, base of the tongue, and hypopharynx. Vocal cord motion is observed, and the pharyngeal musculature is evaluated to assess any functional abnormalities.
  • Step 3: Advancement to the Gastroesophageal Junction - The endoscope is advanced to the cricopharyngeus, where the patient may be asked to burp or swallow to facilitate the passage of the scope. The endoscope is then advanced along the entire length of the esophagus to the gastroesophageal junction.
  • Step 4: Identification of Abnormalities - Any abnormalities encountered during the examination are noted for further evaluation or treatment. This step is essential for determining the need for additional interventions.
  • Step 5: Submucosal Injection(s) - In this step, directed submucosal injection(s) of any substance are performed. Common substances include India ink for tattooing lesions, saline or epinephrine for elevating lesions, and botulinum toxin for treating esophageal achalasia. The injection is performed at the identified lesion site to enhance visibility or facilitate treatment.
  • Step 6: Withdrawal of the Endoscope - After the necessary evaluations and injections are completed, the endoscope is withdrawn. The entire circumference of the esophagus is examined during withdrawal to ensure no abnormalities are overlooked.

3. Post-Procedure

Post-procedure care following CPT® Code 43201 involves monitoring the patient for any immediate complications that may arise from the esophagoscopy and submucosal injections. Patients may experience mild discomfort or a sore throat following the procedure, which typically resolves quickly. It is essential to provide instructions regarding dietary modifications, such as avoiding solid foods for a short period, and to monitor for any signs of complications, such as bleeding or difficulty swallowing. Follow-up appointments may be necessary to discuss the findings and any further treatment options based on the results of the esophagoscopy.

Short Descr ESOPH SCOPE W/SUBMUCOUS INJ
Medium Descr ESOPHAGOSCOPY FLEXIBLE TRANSORAL W SUBMUCOUS INJ
Long Descr Esophagoscopy, flexible, transoral; with directed submucosal injection(s), any substance
Status Code Active Code
Global Days 000 - Endoscopic or Minor Procedure
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 3 - Special payment adjustment rules for multiple endoscopic procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Endoscopic Base Code 43200  Esophagoscopy, flexible, transoral; diagnostic, including collection of specimen(s) by brushing or washing, when performed (separate procedure)
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Hospital Part B services paid through a comprehensive APC
ASC Payment Indicator Surgical procedure on ASC list in CY 2007; payment based on OPPS relative payment weight.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P8B - Endoscopy - upper gastrointestinal
MUE 1
CCS Clinical Classification 70 - Upper gastrointestinal endoscopy, biopsy
22 Increased procedural services: when the work required to provide a service is substantially greater than typically required, it may be identified by adding modifier 22 to the usual procedure code. documentation must support the substantial additional work and the reason for the additional work (ie, increased intensity, time, technical difficulty of procedure, severity of patient's condition, physical and mental effort required). note: this modifier should not be appended to an e/m service.
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
CR Catastrophe/disaster related
GC This service has been performed in part by a resident under the direction of a teaching physician
GW Service not related to the hospice patient's terminal condition
GZ Item or service expected to be denied as not reasonable and necessary
SG Ambulatory surgical center (asc) facility service
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
Date
Action
Notes
2017-01-01 Changed Moderate (Conscious) Sedation flag removed. See new Moderate Sedation category.
2014-01-01 Changed Description Changed
2003-01-01 Added First appearance in code book in 2003.
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