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Official Description

Colonoscopy, flexible; with endoscopic ultrasound examination limited to the rectum, sigmoid, descending, transverse, or ascending colon and cecum, and adjacent structures

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

A flexible colonoscopy with endoscopic ultrasound examination is a diagnostic procedure that combines two techniques to assess the colon and adjacent structures. During this procedure, a flexible colonoscope, which is a long, thin tube equipped with a camera and light, is inserted into the rectum and advanced through the colon to the cecum or the terminal ileum. The use of air insufflation is crucial as it helps to separate the mucosal folds, allowing for enhanced visualization of the colon's interior surface. As the colonoscope is withdrawn, the physician examines the entire circumference of the colon for any signs of disease, injury, or abnormalities.

Following the colonoscopy, an echoendoscope is introduced into the rectum to perform an ultrasound examination. This specialized endoscope is designed to provide high-resolution images of the rectum, colon, cecum, and surrounding structures. To improve the quality of the ultrasound images, the balloon covering the transducer housing is filled with water, which facilitates acoustic coupling. Continuous ultrasound imaging is conducted, enabling the physician to visualize any lesions, masses, or areas of compression, as well as the walls of the colon and pericolonic structures, such as lymph nodes.

In cases where further investigation is warranted, such as in the presence of a mass or lesion, the echoendoscope can be advanced under direct visualization to the area of concern. This allows for the identification of masses that may be located outside the colon or within its muscular wall. Ultrasound images are captured to assist in locating lymph nodes and other lesions that may be suitable for biopsy. A fine needle aspiration or biopsy catheter is then advanced through the echoendoscope's biopsy channel to obtain tissue samples from the identified areas. The procedure may involve multiple passes at each biopsy site to ensure adequate specimen collection, which is subsequently sent to the laboratory for cytologic examination.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The flexible colonoscopy with endoscopic ultrasound examination is indicated for various clinical scenarios, particularly when there is a need to evaluate the colon and adjacent structures for potential abnormalities. The following conditions may warrant this procedure:

  • Suspicion of Colorectal Cancer - Patients presenting with symptoms such as rectal bleeding, unexplained weight loss, or changes in bowel habits may require this procedure to investigate potential malignancies.
  • Assessment of Polyps - Individuals with a history of polyps or those found to have polyps during a previous colonoscopy may undergo this procedure for further evaluation and management.
  • Evaluation of Inflammatory Bowel Disease - Patients with conditions such as Crohn's disease or ulcerative colitis may need this examination to assess disease extent and activity.
  • Investigation of Abdominal Pain - Unexplained abdominal pain may necessitate this procedure to identify any underlying lesions or abnormalities in the colon.
  • Assessment of Lymphadenopathy - Enlarged lymph nodes adjacent to the colon may be evaluated through this procedure to determine the cause and potential need for biopsy.

2. Procedure

The procedure involves several key steps to ensure thorough examination and accurate diagnosis. The following outlines the procedural steps:

  • Step 1: Preparation - Prior to the procedure, the patient undergoes bowel preparation to ensure the colon is clear of any fecal matter, which is essential for optimal visualization during the colonoscopy.
  • Step 2: Insertion of the Colonoscope - The patient is positioned comfortably, and a flexible colonoscope is gently inserted into the rectum. The scope is advanced through the colon, reaching the cecum or terminal ileum while air is insufflated to expand the colon and separate the mucosal folds.
  • Step 3: Visualization and Examination - As the colonoscope is withdrawn, the physician carefully examines the entire circumference of the colon for any signs of disease, injury, or abnormalities, documenting any findings as necessary.
  • Step 4: Introduction of the Echoendoscope - Following the colonoscopic examination, an echoendoscope is inserted into the rectum. This specialized instrument is equipped with ultrasound capabilities to visualize the rectum, colon, cecum, and adjacent structures.
  • Step 5: Ultrasound Imaging - The balloon covering the transducer housing is filled with water to enhance acoustic coupling. Continuous ultrasound imaging is performed, allowing the physician to visualize lesions, masses, and the walls of the colon, as well as pericolonic structures such as lymph nodes.
  • Step 6: Biopsy Procedure (if indicated) - If a lesion or mass is identified, the echoendoscope is advanced to the area of concern. Ultrasound images are obtained to guide the biopsy. A fine needle aspiration/biopsy catheter is advanced through the biopsy channel of the echoendoscope to obtain tissue samples from the lesion or lymph node. Multiple passes may be made to ensure adequate specimen collection.
  • Step 7: Specimen Handling - After each biopsy pass, the biopsy device is removed, cleaned, and reassembled. Once sufficient specimens are obtained, they are sent to the laboratory for cytologic examination.

3. Post-Procedure

After the procedure, patients are monitored for any immediate complications, such as bleeding or perforation. It is common for patients to experience mild discomfort or cramping, which typically resolves shortly after the procedure. Patients are advised to rest and may be instructed to avoid strenuous activities for a short period. Follow-up appointments may be scheduled to discuss biopsy results and any further management based on findings. It is essential for patients to report any unusual symptoms, such as severe abdominal pain or significant bleeding, to their healthcare provider promptly.

Short Descr COLONOSCOPY W/ENDOSCOPE US
Medium Descr COLSC FLX W/NDSC US XM RCTM ET AL LMTD&ADJ STRUX
Long Descr Colonoscopy, flexible; with endoscopic ultrasound examination limited to the rectum, sigmoid, descending, transverse, or ascending colon and cecum, and adjacent structures
Status Code Active Code
Global Days 000 - Endoscopic or Minor Procedure
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 3 - Special payment adjustment rules for multiple endoscopic procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Endoscopic Base Code 45378  Colonoscopy, flexible; diagnostic, including collection of specimen(s) by brushing or washing, when performed (separate procedure)
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Multiple Reduction Applies
ASC Payment Indicator Surgical procedure on ASC list in CY 2007; payment based on OPPS relative payment weight.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P8D - Endoscopy - colonoscopy
MUE 1
CCS Clinical Classification 76 - Colonoscopy and biopsy
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
22 Increased procedural services: when the work required to provide a service is substantially greater than typically required, it may be identified by adding modifier 22 to the usual procedure code. documentation must support the substantial additional work and the reason for the additional work (ie, increased intensity, time, technical difficulty of procedure, severity of patient's condition, physical and mental effort required). note: this modifier should not be appended to an e/m service.
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
GC This service has been performed in part by a resident under the direction of a teaching physician
GZ Item or service expected to be denied as not reasonable and necessary
KX Requirements specified in the medical policy have been met
PT Colorectal cancer screening test; converted to diagnostic test or other procedure
RT Right side (used to identify procedures performed on the right side of the body)
SG Ambulatory surgical center (asc) facility service
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
Date
Action
Notes
2017-01-01 Changed Moderate (Conscious) Sedation flag removed. See new Moderate Sedation category.
2015-01-01 Changed Description Changed
2005-01-01 Added First appearance in code book in 2005.
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