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Official Description

Ablation of malignant prostate tissue, transrectal, with high intensity-focused ultrasound (HIFU), including ultrasound guidance

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The procedure described by CPT® Code 55880 involves the ablation of malignant prostate tissue using high intensity-focused ultrasound (HIFU). This technique is characterized as minimally invasive, utilizing precisely focused sound wave energy to effectively heat and destroy cancerous tissue within the prostate. HIFU is particularly beneficial for patients diagnosed with low to intermediate risk prostate cancer, especially when the prostate is not significantly enlarged. The procedure is performed transrectally, meaning that the ultrasound energy is delivered through the rectal wall, targeting the prostate gland. The identification of the malignant tissue is often aided by magnetic resonance imaging (MRI), which is further confirmed through real-time imaging guidance during the procedure. As the sound waves are directed at the targeted tissue, the temperature at the site is rapidly elevated, leading to the destruction of cancerous cells within a matter of seconds. This method is designed to spare the surrounding healthy tissue, akin to how a magnifying glass focuses light to a point. The ablation process is repeated as necessary to ensure that the entire affected area, or even the entire prostate gland, is treated effectively. Typically, this procedure is completed in a single therapy session, making it a convenient option for patients seeking a radiation-free treatment alternative with minimal side effects.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The procedure described by CPT® Code 55880 is indicated for the treatment of malignant prostate tissue in patients diagnosed with prostate cancer. Specifically, it is appropriate for individuals with low to intermediate risk prostate cancer, particularly when the prostate gland is not excessively enlarged. The use of high intensity-focused ultrasound (HIFU) is aimed at effectively targeting and destroying cancerous cells while minimizing damage to surrounding healthy tissue.

  • Low to Intermediate Risk Prostate Cancer This procedure is suitable for patients who have been classified as having low to intermediate risk prostate cancer, allowing for a targeted approach to treatment.
  • Non-Enlarged Prostate HIFU is indicated when the prostate is not significantly enlarged, ensuring optimal targeting of malignant tissue.

2. Procedure

The procedure for CPT® Code 55880 involves several key steps that ensure the effective ablation of malignant prostate tissue using high intensity-focused ultrasound (HIFU).

  • Step 1: Patient Preparation Prior to the procedure, the patient is prepared, which may include obtaining informed consent and ensuring that the patient understands the procedure and its potential outcomes. The patient is typically positioned comfortably to facilitate access to the prostate through the rectal wall.
  • Step 2: Imaging Guidance The procedure begins with imaging guidance, often utilizing magnetic resonance imaging (MRI) to identify the location of the malignant tissue within the prostate. This imaging is crucial for accurately targeting the cancerous cells during the ablation process.
  • Step 3: Ultrasound Application A transducer is then inserted transrectally, delivering high intensity-focused ultrasound energy across the rectal wall. The sound waves are precisely focused on the identified malignant tissue, rapidly increasing the temperature at the target site.
  • Step 4: Tissue Ablation As the ultrasound energy is applied, the cancerous cells are destroyed within seconds due to the rapid temperature increase. This process is carefully monitored to ensure that surrounding healthy tissue remains unaffected.
  • Step 5: Repetition of Treatment The application of ultrasound energy may be repeated as necessary to ensure complete ablation of the targeted area or the entire prostate gland, depending on the extent of the malignancy.
  • Step 6: Conclusion of Procedure Once the ablation is complete, the transducer is removed, and the procedure is concluded. The patient may then be monitored for any immediate post-procedure effects.

3. Post-Procedure

After the completion of the HIFU procedure, patients are typically monitored for any immediate side effects or complications. Recovery is generally quick, as HIFU is a minimally invasive technique. Patients may experience some discomfort or mild side effects, which are usually transient. Follow-up appointments are essential to assess the effectiveness of the treatment and to monitor for any recurrence of prostate cancer. Additional imaging studies may be performed to evaluate the treated area and ensure that the malignant tissue has been adequately ablated. It is important for patients to adhere to any post-procedure care instructions provided by their healthcare provider to facilitate optimal recovery.

Short Descr ABLTJ MAL PRST8 TISS HIFU
Medium Descr TRANSRECTAL ABLTJ MAL PRST8 TISSUE HIFU W/US
Long Descr Ablation of malignant prostate tissue, transrectal, with high intensity-focused ultrasound (HIFU), including ultrasound guidance
Status Code Active Code
Global Days 090 - Major Surgery
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Hospital Part B services paid through a comprehensive APC
ASC Payment Indicator Non office-based surgical procedure added in CY 2008 or later; payment based on OPPS relative payment weight.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) none
MUE 1
GC This service has been performed in part by a resident under the direction of a teaching physician
22 Increased procedural services: when the work required to provide a service is substantially greater than typically required, it may be identified by adding modifier 22 to the usual procedure code. documentation must support the substantial additional work and the reason for the additional work (ie, increased intensity, time, technical difficulty of procedure, severity of patient's condition, physical and mental effort required). note: this modifier should not be appended to an e/m service.
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
74 Discontinued out-patient hospital/ambulatory surgery center (asc) procedure after administration of anesthesia: due to extenuating circumstances or those that threaten the well being of the patient, the physician may terminate a surgical or diagnostic procedure after the administration of anesthesia (local, regional block(s), general) or after the procedure was started (incision made, intubation started, scope inserted, etc). under these circumstances, the procedure started but terminated can be reported by its usual procedure number and the addition of modifier 74. note: the elective cancellation of a service prior to the administration of anesthesia and/or surgical preparation of the patient should not be reported. for physician reporting of a discontinued procedure, see modifier 53.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
80 Assistant surgeon: surgical assistant services may be identified by adding modifier 80 to the usual procedure number(s).
82 Assistant surgeon (when qualified resident surgeon not available): the unavailability of a qualified resident surgeon is a prerequisite for use of modifier 82 appended to the usual procedure code number(s).
CR Catastrophe/disaster related
GX Notice of liability issued, voluntary under payer policy
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
LT Left side (used to identify procedures performed on the left side of the body)
RT Right side (used to identify procedures performed on the right side of the body)
Date
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Notes
2021-01-01 Added Code added.
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