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Official Description

Biopsy of vulva or perineum (separate procedure); 1 lesion

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The procedure described by CPT® Code 56605 refers to a biopsy of the vulva or perineum, specifically when only one lesion is involved. A biopsy is a medical procedure that involves the removal of a small sample of tissue from the body for diagnostic purposes. In this case, the biopsy targets lesions located in the vulvar or perineal area, which are parts of the female genitalia. The process begins with the cleansing of the skin to minimize the risk of infection, followed by the administration of a local anesthetic to ensure the patient experiences minimal discomfort during the procedure. Once the area is adequately numbed, a tissue sample is carefully excised from the lesion. This sample is then sent to a laboratory for pathology examination, where it will be analyzed to determine the presence of any abnormalities, such as cancerous cells or other conditions. It is important to note that this code is specifically for a single lesion; if additional lesions require biopsy, a different code, CPT® Code 56606, should be used for each additional lesion biopsied. This distinction is crucial for accurate medical coding and billing purposes.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The biopsy of the vulva or perineum, as indicated by CPT® Code 56605, is performed for various reasons related to the assessment of lesions in these areas. The following conditions may warrant this procedure:

  • Suspicious Lesions Lesions that exhibit abnormal characteristics, such as changes in color, shape, or size, which may suggest the presence of malignancy or other pathological conditions.
  • Persistent Symptoms Symptoms such as pain, itching, or bleeding in the vulvar or perineal region that do not respond to conservative treatment may necessitate a biopsy to determine the underlying cause.
  • Follow-Up on Previous Findings Patients with a history of abnormal Pap smears or previous biopsies may require further evaluation of new or existing lesions to monitor for potential changes.

2. Procedure

The procedure for performing a biopsy of the vulva or perineum involves several key steps, each critical to ensuring the safety and effectiveness of the biopsy:

  • Step 1: Preparation The area surrounding the lesion is first cleansed thoroughly with an antiseptic solution to reduce the risk of infection. This step is essential to maintain a sterile environment during the procedure.
  • Step 2: Anesthesia A local anesthetic is then injected into the area around the lesion. This is done to numb the tissue, ensuring that the patient experiences minimal discomfort during the biopsy process.
  • Step 3: Tissue Sample Collection Once the area is adequately anesthetized, the physician carefully excises a small sample of tissue from the lesion. This is done using a scalpel or biopsy punch, depending on the size and type of the lesion. The goal is to obtain a sufficient amount of tissue for accurate pathological evaluation.
  • Step 4: Specimen Handling The excised tissue sample is then placed in a suitable container, often containing a preservative solution, and labeled appropriately for transport to the laboratory. This ensures that the sample is preserved for accurate analysis.
  • Step 5: Post-Procedure Care After the biopsy is completed, the site may be dressed with a sterile bandage, and the patient is given instructions on how to care for the biopsy site to promote healing and prevent infection.

3. Post-Procedure

Following the biopsy of the vulva or perineum, patients can expect some degree of discomfort or tenderness at the biopsy site, which is typically manageable with over-the-counter pain relief. It is important for patients to follow any post-procedure care instructions provided by their healthcare provider, which may include keeping the area clean and dry, avoiding strenuous activities, and monitoring for signs of infection, such as increased redness, swelling, or discharge. Patients should also be informed about when to expect the results of the pathology examination and advised to schedule a follow-up appointment to discuss the findings and any necessary next steps based on the results.

Short Descr BIOPSY OF VULVA/PERINEUM
Medium Descr BIOPSY VULVA/PERINEUM 1 LESION SPX
Long Descr Biopsy of vulva or perineum (separate procedure); 1 lesion
Status Code Active Code
Global Days 000 - Endoscopic or Minor Procedure
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 2 - Co-surgeons permitted and no documentation required if the two- specialty requirement is met.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Multiple Reduction Applies
ASC Payment Indicator Office-based surgical procedure added to ASC list in CY 2008 or later with MPFS nonfacility PE RVUs; payment based on MPFS nonfacility PE RVUs.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P5E - Ambulatory procedures - other
MUE 1
CCS Clinical Classification 130 - Other diagnostic procedures, female organs

This is a primary code that can be used with these additional add-on codes.

56606 Female Edit Addon Code MPFS Status: Active Code APC N ASC N1 CPT Assistant Article Illustration for Code Biopsy of vulva or perineum (separate procedure); each separate additional lesion (List separately in addition to code for primary procedure)
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
GC This service has been performed in part by a resident under the direction of a teaching physician
GA Waiver of liability statement issued as required by payer policy, individual case
CR Catastrophe/disaster related
22 Increased procedural services: when the work required to provide a service is substantially greater than typically required, it may be identified by adding modifier 22 to the usual procedure code. documentation must support the substantial additional work and the reason for the additional work (ie, increased intensity, time, technical difficulty of procedure, severity of patient's condition, physical and mental effort required). note: this modifier should not be appended to an e/m service.
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
56 Preoperative management only: when 1 physician or other qualified health care professional performed the preoperative care and evaluation and another performed the surgical procedure, the preoperative component may be identified by adding modifier 56 to the usual procedure number.
57 Decision for surgery: an evaluation and management service that resulted in the initial decision to perform the surgery may be identified by adding modifier 57 to the appropriate level of e/m service.
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
80 Assistant surgeon: surgical assistant services may be identified by adding modifier 80 to the usual procedure number(s).
82 Assistant surgeon (when qualified resident surgeon not available): the unavailability of a qualified resident surgeon is a prerequisite for use of modifier 82 appended to the usual procedure code number(s).
AG Primary physician
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
FS Split (or shared) evaluation and management visit
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
GZ Item or service expected to be denied as not reasonable and necessary
KX Requirements specified in the medical policy have been met
LT Left side (used to identify procedures performed on the left side of the body)
PO Excepted service provided at an off-campus, outpatient, provider-based department of a hospital
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
RT Right side (used to identify procedures performed on the right side of the body)
SA Nurse practitioner rendering service in collaboration with a physician
SB Nurse midwife
SG Ambulatory surgical center (asc) facility service
UA Medicaid level of care 10, as defined by each state
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
Date
Action
Notes
2010-01-01 Changed Code description changed.
1993-01-01 Added First appearance in code book in 1993.
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