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Official Description

Biopsy of vaginal mucosa; simple (separate procedure)

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 57100 refers to a simple biopsy of the vaginal mucosa, which is classified as a separate procedure. This procedure involves the physician obtaining a tissue sample from the vaginal mucosa, which is the moist tissue lining the vagina. Prior to the biopsy, the area is prepared by cleansing the skin to reduce the risk of infection, and a local anesthetic is administered to minimize discomfort during the procedure. The biopsy is performed to assess any abnormalities or lesions present in the vaginal mucosa, and the collected tissue sample is subsequently sent to a laboratory for pathology examination. It is important to note that this procedure does not require suture repair at the biopsy site, distinguishing it from more extensive biopsies, such as those coded under CPT® 57105, which involve larger tissue removal and require suturing. The simplicity of the procedure and the absence of sutures make CPT® 57100 a straightforward option for obtaining necessary diagnostic information from the vaginal mucosa.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The procedure coded as CPT® 57100 is indicated for the evaluation of various abnormalities or lesions found in the vaginal mucosa. The following conditions may warrant a simple biopsy:

  • Vaginal Lesions - Any abnormal growths or lesions on the vaginal mucosa that require histological examination to determine their nature.
  • Suspicion of Pathology - Situations where there is a clinical suspicion of malignancy or other pathological conditions necessitating tissue diagnosis.
  • Monitoring of Known Conditions - Patients with previously diagnosed conditions that may require follow-up biopsies to assess changes in the tissue.

2. Procedure

The procedure for CPT® 57100 involves several key steps to ensure proper execution and patient safety. First, the physician prepares the patient by explaining the procedure and obtaining informed consent. Following this, the area around the vaginal mucosa is thoroughly cleansed with an antiseptic solution to minimize the risk of infection. Once the area is prepared, a local anesthetic is injected to numb the site, ensuring that the patient experiences minimal discomfort during the biopsy.

  • Step 1: Cleansing and Anesthesia The physician begins by cleansing the vaginal area with an antiseptic solution to reduce the risk of infection. After cleansing, a local anesthetic is injected into the vaginal mucosa to numb the area, allowing the procedure to be performed with minimal discomfort to the patient.
  • Step 2: Biopsy Procedure After the local anesthetic takes effect, the physician carefully excises a small sample of tissue from the vaginal mucosa. This is done using a biopsy instrument, which may include a punch or scalpel, depending on the specific characteristics of the lesion. The tissue sample is then collected and placed in a specimen container for laboratory analysis.
  • Step 3: Post-Procedure Care Once the biopsy is completed, the physician inspects the biopsy site to ensure there is no excessive bleeding. Since this is a simple biopsy, no sutures are required to close the site. The physician may provide the patient with aftercare instructions, including how to care for the biopsy site and what symptoms to monitor for in the days following the procedure.

3. Post-Procedure

After the completion of the biopsy, the patient is typically monitored for a short period to ensure there are no immediate complications, such as excessive bleeding or adverse reactions to the anesthetic. The biopsy site does not require sutures, which simplifies the post-procedure care. Patients are usually advised to avoid sexual intercourse and the use of tampons for a specified period to allow for proper healing. Additionally, they may be instructed to keep the area clean and to report any signs of infection, such as increased pain, swelling, or discharge. The results of the pathology examination will be communicated to the patient once available, guiding any further management or treatment if necessary.

Short Descr BIOPSY VAGINAL MUCOSA SIMPLE
Medium Descr BIOPSY VAGINAL MUCOSA SIMPLE
Long Descr Biopsy of vaginal mucosa; simple (separate procedure)
Status Code Active Code
Global Days 000 - Endoscopic or Minor Procedure
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Multiple Reduction Applies
ASC Payment Indicator Office-based surgical procedure added to ASC list in CY 2008 or later with MPFS nonfacility PE RVUs; payment based on MPFS nonfacility PE RVUs.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P6C - Minor procedures - other (Medicare fee schedule)
MUE 2
CCS Clinical Classification 130 - Other diagnostic procedures, female organs
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
22 Increased procedural services: when the work required to provide a service is substantially greater than typically required, it may be identified by adding modifier 22 to the usual procedure code. documentation must support the substantial additional work and the reason for the additional work (ie, increased intensity, time, technical difficulty of procedure, severity of patient's condition, physical and mental effort required). note: this modifier should not be appended to an e/m service.
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
80 Assistant surgeon: surgical assistant services may be identified by adding modifier 80 to the usual procedure number(s).
AG Primary physician
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
CR Catastrophe/disaster related
FS Split (or shared) evaluation and management visit
GA Waiver of liability statement issued as required by payer policy, individual case
GC This service has been performed in part by a resident under the direction of a teaching physician
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
SG Ambulatory surgical center (asc) facility service
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
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2025-01-01 Changed Short Description changed.
Pre-1990 Added Code added.
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