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Official Description

Injection, anesthetic agent; sphenopalatine ganglion

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The sphenopalatine ganglion, also known by various names such as the pterygopalatine ganglion, nasal ganglion, Meckel's ganglion, or SPG, is a small but significant cluster of nerves that encompasses sympathetic, parasympathetic, and sensory nerve fibers. This ganglion plays a crucial role in the autonomic nervous system and is located posterior to the nasal cavity. The procedure associated with CPT® code 64505 involves the injection of a local anesthetic agent directly into the sphenopalatine ganglion. This targeted approach is utilized primarily for the management of headaches stemming from various causes, as well as for conditions such as trigeminal neuralgia, which is characterized by severe facial pain. It is important to note that the technique described by this code specifically refers to the injection method, which involves the insertion of a needle through the cheek to reach the ganglion. Alternative methods, such as the use of an anesthetic-coated cotton swab applied intranasally or the SphenoCath catheter technique, do not qualify as injections and therefore do not fall under the description of code 64505. These alternative techniques may be reported differently, either as part of an evaluation and management (E/M) service or using the unlisted code 64999.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The injection of an anesthetic agent into the sphenopalatine ganglion is indicated for the treatment of various conditions that involve headache relief and facial pain management. The following are specific indications for this procedure:

  • Headaches - This procedure is performed to alleviate headaches of varying etiology, which may include tension-type headaches, cluster headaches, and migraines.
  • Trigeminal Neuralgia - The injection is indicated for patients suffering from trigeminal neuralgia, a condition characterized by episodes of severe facial pain that can be debilitating.

2. Procedure

The procedure for the injection of an anesthetic agent into the sphenopalatine ganglion involves several key steps, which are detailed as follows:

  • Step 1: Patient Preparation - The patient is positioned comfortably, and the area of the cheek where the needle will be inserted is prepared. This may involve cleaning the skin to reduce the risk of infection.
  • Step 2: Identification of the Injection Site - The clinician identifies the appropriate anatomical landmarks to ensure accurate placement of the needle. This is crucial for targeting the sphenopalatine ganglion effectively.
  • Step 3: Needle Insertion - A needle is carefully inserted through the cheek, guided towards the sphenopalatine ganglion. The clinician must navigate through the tissues while minimizing discomfort to the patient.
  • Step 4: Injection of Anesthetic - Once the needle is correctly positioned, a local anesthetic agent is injected into the ganglion. This step is essential for achieving the desired therapeutic effect of pain relief.
  • Step 5: Post-Injection Monitoring - After the injection, the patient is monitored for any immediate adverse reactions and to assess the effectiveness of the procedure. This may involve observing the patient for a short period before discharge.

3. Post-Procedure

Post-procedure care following the injection into the sphenopalatine ganglion typically includes monitoring the patient for any side effects or complications that may arise from the injection. Patients may experience temporary numbness or tingling in the area where the anesthetic was administered. It is important for the clinician to provide the patient with instructions regarding potential side effects and when to seek further medical attention. Additionally, patients may be advised to avoid strenuous activities for a short period following the procedure to ensure optimal recovery. Follow-up appointments may be scheduled to evaluate the effectiveness of the treatment and to determine if additional interventions are necessary.

Short Descr N BLOCK SPENOPALATINE GANGL
Medium Descr INJECTION ANES AGENT SPHENOPALATINE GANGLION
Long Descr Injection, anesthetic agent; sphenopalatine ganglion
Status Code Active Code
Global Days 000 - Endoscopic or Minor Procedure
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 1 - 150% payment adjustment for bilateral procedures applies.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Multiple Reduction Applies
ASC Payment Indicator Office-based surgical procedure added to ASC list in CY 2008 or later with MPFS nonfacility PE RVUs; payment based on MPFS nonfacility PE RVUs.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P6C - Minor procedures - other (Medicare fee schedule)
MUE 1
CCS Clinical Classification 8 - Other non-OR or closed therapeutic nervous system procedures

This is a primary code that can be used with these additional add-on codes.

77002 CPT Add On MPFS Status: Active Code APC N ASC N1 Physician Quality Reporting CPT Assistant Article Fluoroscopic guidance for needle placement (eg, biopsy, aspiration, injection, localization device) (List separately in addition to code for primary procedure)
50 Bilateral procedure: unless otherwise identified in the listings, bilateral procedures that are performed at the same session, should be identified by adding modifier 50 to the appropriate 5 digit code. note: this modifier should not be appended to designated "add-on" codes (see appendix d).
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
RT Right side (used to identify procedures performed on the right side of the body)
LT Left side (used to identify procedures performed on the left side of the body)
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
X2 Continuous/focused services: for reporting services by clinicians whose expertise is needed for the ongoing management of a chronic disease or a condition that needs to be managed and followed with no planned endpoint to the relationship; reporting clinician service examples include but are not limited to: a rheumatologist taking care of the patient's rheumatoid arthritis longitudinally but not providing general primary care services
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
73 Discontinued out-patient hospital/ambulatory surgery center (asc) procedure prior to the administration of anesthesia: due to extenuating circumstances or those that threaten the well being of the patient, the physician may cancel a surgical or diagnostic procedure subsequent to the patient's surgical preparation (including sedation when provided, and being taken to the room where the procedure is to be performed), but prior to the administration of anesthesia (local, regional block(s) or general). under these circumstances, the intended service that is prepared for but cancelled can be reported by its usual procedure number and the addition of modifier 73. note: the elective cancellation of a service prior to the administration of anesthesia and/or surgical preparation of the patient should not be reported. for physician reporting of a discontinued procedure, see modifier 53.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
CR Catastrophe/disaster related
GA Waiver of liability statement issued as required by payer policy, individual case
GC This service has been performed in part by a resident under the direction of a teaching physician
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GZ Item or service expected to be denied as not reasonable and necessary
KX Requirements specified in the medical policy have been met
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
Date
Action
Notes
2011-01-01 Changed Short description changed.
Pre-1990 Added Code added.
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