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Official Description

Chemodenervation of trunk muscle(s); 1-5 muscle(s)

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

Chemodenervation refers to a medical procedure aimed at reducing involuntary muscle contractions or spasms, particularly in the muscles of the trunk. This technique is commonly utilized for patients suffering from conditions such as dystonia, cerebral palsy, or multiple sclerosis, where muscle control is compromised. The procedure involves the injection of botulinum toxin, either type A or B, directly into the targeted muscle. This toxin works by temporarily paralyzing the muscle, effectively blocking the release of acetylcholine at the peripheral nerve endings. By interrupting the neuromuscular transmission of nerve impulses, the procedure alleviates the symptoms associated with muscle spasms. Prior to the injection, healthcare professionals determine the specific muscles to be treated through methods such as electromyography or physical examination, which includes palpating the muscles and identifying the locations of spasms. The trunk area is then prepared for the procedure, and the selected muscle(s) are injected at precise sites to achieve the desired denervation effect. For coding purposes, the CPT® code 64646 is designated for the treatment of 1-5 trunk muscles, while 64647 is used for procedures involving 6 or more trunk muscles.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

Chemodenervation of trunk muscle(s) is indicated for the treatment of various conditions characterized by involuntary muscle contractions or spasms. The following are the explicitly provided indications for this procedure:

  • Dystonia A movement disorder that causes sustained muscle contractions, resulting in twisting and repetitive movements or abnormal postures.
  • Cerebral Palsy A group of disorders affecting movement and muscle tone, often caused by damage to the developing brain, leading to muscle stiffness or spasms.
  • Multiple Sclerosis A chronic disease affecting the central nervous system, which can lead to muscle weakness, spasms, and coordination issues.

2. Procedure

The procedure for chemodenervation of trunk muscle(s) involves several key steps to ensure effective treatment. The following procedural steps are outlined:

  • Step 1: Patient Assessment The healthcare provider begins by assessing the patient’s condition, including a thorough review of their medical history and symptoms. This assessment helps to identify the specific muscles affected by involuntary contractions or spasms.
  • Step 2: Muscle Identification The provider utilizes electromyography or a physical examination to identify the specific trunk muscles that require treatment. This may involve palpating the muscles to locate areas of spasm and determining the most appropriate injection sites.
  • Step 3: Preparation of the Trunk Once the target muscles are identified, the trunk area is prepared for the procedure. This preparation may include cleaning the skin to reduce the risk of infection and ensuring the patient is comfortable.
  • Step 4: Injection of Botulinum Toxin The healthcare provider then carefully injects botulinum toxin into the selected muscle(s) at the predetermined sites. The dosage and number of injection sites depend on the number of muscles being treated, with the CPT® code 64646 applicable for 1-5 muscles.
  • Step 5: Post-Injection Monitoring After the injections, the patient is monitored for any immediate adverse reactions and to assess the initial effectiveness of the treatment. Follow-up appointments may be scheduled to evaluate the long-term outcomes of the procedure.

3. Post-Procedure

Post-procedure care for patients who have undergone chemodenervation of trunk muscle(s) typically includes monitoring for any side effects or complications related to the injections. Patients may experience temporary weakness in the injected muscles, which is expected as the botulinum toxin takes effect. It is important for patients to follow any specific aftercare instructions provided by their healthcare provider, which may include avoiding strenuous activities for a short period following the procedure. Additionally, follow-up visits are essential to assess the effectiveness of the treatment and determine if further injections are necessary. The expected recovery time can vary, but many patients begin to notice improvements in muscle control and a reduction in spasms within a few days to weeks following the procedure.

Short Descr CHEMODENERV TRUNK MUSC 1-5
Medium Descr CHEMODENERVATION OF TRUNK MUSCLE 1-5 MUSCLES
Long Descr Chemodenervation of trunk muscle(s); 1-5 muscle(s)
Status Code Active Code
Global Days 000 - Endoscopic or Minor Procedure
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Multiple Reduction Applies
ASC Payment Indicator Office-based surgical procedure added to ASC list in CY 2008 or later with MPFS nonfacility PE RVUs; payment based on MPFS nonfacility PE RVUs.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P6C - Minor procedures - other (Medicare fee schedule)
MUE 1

This is a primary code that can be used with these additional add-on codes.

95873 Addon Code MPFS Status: Active Code APC N CPT Assistant Article Electrical stimulation for guidance in conjunction with chemodenervation (List separately in addition to code for primary procedure)
95874 Addon Code MPFS Status: Active Code APC N CPT Assistant Article Needle electromyography for guidance in conjunction with chemodenervation (List separately in addition to code for primary procedure)
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
GC This service has been performed in part by a resident under the direction of a teaching physician
LT Left side (used to identify procedures performed on the left side of the body)
22 Increased procedural services: when the work required to provide a service is substantially greater than typically required, it may be identified by adding modifier 22 to the usual procedure code. documentation must support the substantial additional work and the reason for the additional work (ie, increased intensity, time, technical difficulty of procedure, severity of patient's condition, physical and mental effort required). note: this modifier should not be appended to an e/m service.
50 Bilateral procedure: unless otherwise identified in the listings, bilateral procedures that are performed at the same session, should be identified by adding modifier 50 to the appropriate 5 digit code. note: this modifier should not be appended to designated "add-on" codes (see appendix d).
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
AG Primary physician
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
CR Catastrophe/disaster related
GA Waiver of liability statement issued as required by payer policy, individual case
GT Via interactive audio and video telecommunication systems
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
GZ Item or service expected to be denied as not reasonable and necessary
RT Right side (used to identify procedures performed on the right side of the body)
X2 Continuous/focused services: for reporting services by clinicians whose expertise is needed for the ongoing management of a chronic disease or a condition that needs to be managed and followed with no planned endpoint to the relationship; reporting clinician service examples include but are not limited to: a rheumatologist taking care of the patient's rheumatoid arthritis longitudinally but not providing general primary care services
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
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2014-01-01 Added Added
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