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Official Description

Destruction by neurolytic agent, with or without radiologic monitoring; celiac plexus

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The celiac plexus is a complex network of nerves located in the retroperitoneum of the upper abdomen, specifically at the level of the T12-L1 vertebrae, situated anterior to the crura of the diaphragm. This plexus encircles critical vascular structures, including the abdominal aorta, celiac artery, and superior mesenteric artery. The procedure coded as CPT® 64680 involves the destruction of the celiac plexus using a neurolytic agent, which can be administered with or without the aid of radiologic monitoring. The primary purpose of this intervention is to alleviate pain associated with metastatic cancer, as well as to manage nonmalignant pain conditions, such as those arising from acute and chronic pancreatitis. The destruction of the celiac plexus can be achieved through various techniques, including the injection of a chemical neurolytic agent or the application of thermal, electrical, or radiofrequency methods. When radiologic monitoring is utilized, precise needle placement is confirmed through imaging, ensuring that the neurolytic agent is accurately delivered to the targeted nerve structures. This procedure is significant in pain management, providing relief to patients suffering from debilitating abdominal pain.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The destruction of the celiac plexus is indicated for the management of severe abdominal pain associated with specific medical conditions. The following are the primary indications for this procedure:

  • Metastatic Cancer Pain Pain resulting from the spread of cancer to the abdominal organs, which can lead to significant discomfort and reduced quality of life.
  • Nonmalignant Pain Pain that is not related to cancer, particularly pain due to acute and chronic pancreatitis, which can cause debilitating symptoms and necessitate intervention for relief.

2. Procedure

The procedure for celiac plexus destruction involves several critical steps to ensure effective treatment. The following outlines the procedural steps:

  • Step 1: Patient Preparation The patient is positioned appropriately, typically lying on their back, to allow access to the upper abdomen. Monitoring of vital signs is established, and the area of intervention is sterilized to minimize the risk of infection.
  • Step 2: Needle Insertion If radiologic monitoring is employed, two needles are inserted on each side of the upper abdomen, directed toward the body of the L1 vertebra. In cases where neurolysis is limited to the splanchnic nerves, the needles may be directed toward T12. This precise placement is crucial for effective neurolysis.
  • Step 3: Confirmation of Needle Placement Contrast material is injected through the needles to confirm that they are correctly positioned adjacent to the celiac plexus. This step is essential to ensure that the neurolytic agent will be delivered accurately to the targeted nerve structures.
  • Step 4: Injection of Neurolytic Agent If a chemical neurolytic agent is chosen, it is injected through the needles into the celiac plexus. Common agents include phenol, ethyl alcohol, glycerol, ammonium salt compounds, and hypertonic or hypotonic solutions.
  • Step 5: Thermal or Electrical Techniques Alternatively, if thermal or electrical modalities are used, a probe or needle is inserted through the skin and activated to generate heat, effectively destroying the nerve tissue. For radiofrequency nerve destruction, an electrode needle is advanced toward the targeted neural tissue, and once positioned correctly, an electric current is applied to produce heat at the electrode tip, leading to the destruction of the nerve tissue.

3. Post-Procedure

After the celiac plexus destruction procedure, patients are typically monitored for any immediate complications or adverse reactions. Post-procedure care may include pain management strategies, as some patients may experience transient discomfort at the injection site. It is essential to provide instructions regarding activity restrictions and signs of potential complications, such as infection or excessive bleeding. Patients may be advised to follow up with their healthcare provider to assess the effectiveness of the procedure in alleviating pain and to discuss any further treatment options if necessary. Recovery times can vary, but many patients may experience significant pain relief shortly after the procedure, contributing to improved quality of life.

Short Descr INJECTION TREATMENT OF NERVE
Medium Descr DSTRJ NEUROLYTIC W/WO RAD MONITOR CELIAC PLEXUS
Long Descr Destruction by neurolytic agent, with or without radiologic monitoring; celiac plexus
Status Code Active Code
Global Days 010 - Minor Procedure
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Multiple Reduction Applies
ASC Payment Indicator Surgical procedure on ASC list in CY 2007; payment based on OPPS relative payment weight.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P6C - Minor procedures - other (Medicare fee schedule)
MUE 1
CCS Clinical Classification 8 - Other non-OR or closed therapeutic nervous system procedures
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
RT Right side (used to identify procedures performed on the right side of the body)
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
54 Surgical care only: when 1 physician or other qualified health care professional performs a surgical procedure and another provides preoperative and/or postoperative management, surgical services may be identified by adding modifier 54 to the usual procedure number.
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
CM At least 80 percent but less than 100 percent impaired, limited or restricted
GC This service has been performed in part by a resident under the direction of a teaching physician
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
LT Left side (used to identify procedures performed on the left side of the body)
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
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2004-01-01 Changed Code description changed.
Pre-1990 Added Code added.
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