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A nerve biopsy is a surgical procedure that involves the removal of a small segment of nerve tissue for diagnostic evaluation. This procedure is typically indicated when there is a need to investigate a nerve lesion or to determine the underlying cause of symptoms such as pain, weakness, or numbness, particularly when other diagnostic methods—such as patient history, clinical examination, laboratory tests, and imaging studies—have not provided a definitive diagnosis. During the procedure, a skin incision is made directly over the targeted nerve, allowing for access to the nerve tissue. The surrounding soft tissues are carefully dissected to expose the nerve, from which a tissue sample is obtained. This sample may consist of a portion of the nerve lesion or a small segment of the nerve itself, which is then sent to a laboratory for pathology examination. Following the biopsy, the soft tissue and skin are meticulously closed in layers to promote proper healing and minimize complications.
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The nerve biopsy procedure is indicated for several specific clinical scenarios where further investigation is necessary to understand the underlying pathology affecting nerve function. The following conditions may warrant a nerve biopsy:
The nerve biopsy procedure involves several critical steps to ensure accurate tissue sampling and patient safety. The following outlines the procedural steps:
Post-procedure care following a nerve biopsy is essential for ensuring proper recovery and minimizing complications. Patients are typically monitored for any immediate adverse reactions to the procedure. Pain management may be provided as needed, and patients are advised on how to care for the incision site to prevent infection. Follow-up appointments may be scheduled to review pathology results and assess the healing process. Patients should be informed about signs of complications, such as increased pain, swelling, or discharge from the incision site, and instructed to seek medical attention if these occur. Overall, the recovery period may vary depending on the individual and the extent of the procedure, but most patients can expect to resume normal activities within a few days, barring any complications.
| Short Descr | BIOPSY OF NERVE | Medium Descr | BIOPSY NERVE | Long Descr | Biopsy of nerve | Status Code | Active Code | Global Days | 000 - Endoscopic or Minor Procedure | PC/TC Indicator (26, TC) | 0 - Physician Service Code | Multiple Procedures (51) | 2 - Standard payment adjustment rules for multiple procedures apply. | Bilateral Surgery (50) | 0 - 150% payment adjustment for bilateral procedures does NOT apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 1 - Statutory payment restriction for assistants at surgery applies to this procedure... | Co-Surgeons (62) | 0 - Co-surgeons not permitted for this procedure. | Team Surgery (66) | 0 - Team surgeons not permitted for this procedure. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | APC Status Indicator | Hospital Part B services paid through a comprehensive APC | ASC Payment Indicator | Surgical procedure on ASC list in CY 2007; payment based on OPPS relative payment weight. | Type of Service (TOS) | 2 - Surgery | Berenson-Eggers TOS (BETOS) | P5E - Ambulatory procedures - other | MUE | 2 | CCS Clinical Classification | 7 - Other diagnostic nervous system procedures |
| 51 | Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d). | 58 | Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78. | 59 | Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25. | 78 | Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.) | 79 | Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.) | AS | Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery | CR | Catastrophe/disaster related | F5 | Right hand, thumb | F9 | Right hand, fifth digit | GC | This service has been performed in part by a resident under the direction of a teaching physician | LT | Left side (used to identify procedures performed on the left side of the body) | RT | Right side (used to identify procedures performed on the right side of the body) | SG | Ambulatory surgical center (asc) facility service | XE | Separate encounter, a service that is distinct because it occurred during a separate encounter | XS | Separate structure, a service that is distinct because it was performed on a separate organ/structure | XU | Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service |
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