© Copyright 2025 American Medical Association. All rights reserved.
The CPT® Code 78111 refers to a laboratory test that measures plasma volume (PV) using a radiopharmaceutical volume-dilution technique, specifically when multiple samplings are performed. This procedure is essential in evaluating various medical conditions related to blood volume, such as hypovolemia, which is a decreased blood volume, and hypervolemia, which indicates an increased blood volume. It is also utilized in cases of acute blood loss and shock, where understanding the plasma volume can guide treatment decisions. The test employs radiolabeled protein tracers, primarily I-125 radioiodinated serum albumin (I-125 RISA), although Technetium-99m (99mTc) human serum albumin (HSA) may also be utilized. The process begins with the collection of the patient's height and weight to ensure accurate calculations. Following this, venous access is established, and a baseline blood sample is collected. The radiolabeled pharmaceutical is then injected, allowing it to circulate throughout the body. Subsequent venipunctures are performed to draw blood samples, which can be done either as a single sample or multiple samples at predetermined intervals. Each sample undergoes a microhematocrit measurement, and the remaining blood is centrifuged to separate the plasma from red blood cells. The data obtained from the patient's samples are analyzed using specific formulas that compare the dilution factors of the radiolabeled tracer with standardized samples, taking into account the patient's individual height, weight, and hematocrit levels. This comprehensive approach ensures accurate assessment of plasma volume, which is critical for effective patient management.
© Copyright 2025 Coding Ahead. All rights reserved.
The procedure associated with CPT® Code 78111 is indicated for the evaluation of various conditions related to blood volume abnormalities. The following are the specific indications for performing this test:
The procedure for CPT® Code 78111 involves several detailed steps to accurately measure plasma volume using a radiopharmaceutical volume-dilution technique. The following outlines the procedural steps:
After the completion of the plasma volume measurement procedure, patients may be monitored for any immediate reactions to the radiopharmaceutical used. There are typically no specific post-procedure care requirements, but patients should be informed about potential side effects related to the tracer, although these are generally minimal. The results of the plasma volume assessment will be analyzed and reported, providing critical information for the management of the patient's condition. Follow-up care may be necessary depending on the underlying issues being evaluated, and healthcare providers will determine the appropriate next steps based on the results obtained from the test.
| Short Descr | PLASMA VOLUME MULTIPLE | Medium Descr | PLASMA VOL RADIOPHARM VOL DILUTE SPX MULT SMPLES | Long Descr | Plasma volume, radiopharmaceutical volume-dilution technique (separate procedure); multiple samplings | Status Code | Active Code | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 1 - Diagnostic Tests for Radiology Services | Multiple Procedures (51) | 0 - No payment adjustment rules for multiple procedures apply. | Bilateral Surgery (50) | 0 - 150% payment adjustment for bilateral procedures does NOT apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 0 - Payment restriction for assistants at surgery applies to this procedure... | Co-Surgeons (62) | 0 - Co-surgeons not permitted for this procedure. | Team Surgery (66) | 0 - Team surgeons not permitted for this procedure. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | APC Status Indicator | Procedure or Service, Not Discounted when Multiple | ASC Payment Indicator | Radiology service paid separately when provided integral to a surgical procedure on ASC list; payment based on OPPS relative payment weight. | Type of Service (TOS) | 4 - Diagnostic Radiology | Berenson-Eggers TOS (BETOS) | I1E - Standard imaging - nuclear medicine | MUE | 1 | CCS Clinical Classification | 210 - Other radioisotope scan |
| 26 | Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number. | MH | Unknown if ordering professional consulted a clinical decision support mechanism for this service, related information was not provided to the furnishing professional or provider | MG | The order for this service does not have applicable appropriate use criteria in the qualified clinical decision support mechanism consulted by the ordering professional | GC | This service has been performed in part by a resident under the direction of a teaching physician | MC | Ordering professional is not required to consult a clinical decision support mechanism due to the significant hardship exception of electronic health record or clinical decision support mechanism vendor issues | ME | The order for this service adheres to appropriate use criteria in the clinical decision support mechanism consulted by the ordering professional | X5 | Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician |
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| 2011-01-01 | Changed | Short description changed. |
| Pre-1990 | Added | Code added. |