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Official Description

Hepatobiliary system imaging, including gallbladder when present; with pharmacologic intervention, including quantitative measurement(s) when performed

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 78227 refers to a specialized imaging procedure known as hepatobiliary system imaging, which is crucial for assessing the liver and its associated structures. This imaging technique utilizes a radioactive tracer to visualize the production and flow of bile from the liver to the small intestine. The procedure is particularly significant in evaluating liver function, as it provides insights into bile production and excretion, as well as the condition of the drainage system, including the bile ducts and gallbladder. The term "HIDA scan," which stands for hepatobiliary iminodiacetic acid scan, is commonly used to describe this procedure. During the imaging process, an intravenous catheter is inserted, and the radioactive tracer is injected into the patient's bloodstream. A gamma camera is then employed to capture multiple images as the tracer moves through the body, highlighting the liver, bile ducts, and gallbladder, provided the gallbladder is intact. The continuous imaging allows for real-time observation of the tracer's journey from the liver through the biliary ducts into the gallbladder and subsequently into the duodenum. In the context of CPT® Code 78227, the procedure is enhanced by the administration of pharmacologic interventions, which may include medications aimed at improving the quality of gallbladder images or stimulating gallbladder contraction. Additionally, a gallbladder ejection fraction test may be performed to quantitatively measure the rate at which bile is expelled from the gallbladder, providing further diagnostic information.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The hepatobiliary system imaging procedure coded as CPT® 78227 is indicated for various clinical scenarios where evaluation of liver function and the biliary system is necessary. The following conditions may warrant this imaging study:

  • Evaluation of Liver Function This procedure is performed to assess the liver's ability to produce and excrete bile, which is essential for digestion and metabolic processes.
  • Investigation of Biliary Obstruction It is indicated when there is a suspicion of obstruction within the bile ducts that may impede the flow of bile from the liver to the intestine.
  • Assessment of Gallbladder Conditions The imaging is useful in evaluating the gallbladder for inflammation, gallstones, or other abnormalities that may affect its function.
  • Monitoring Post-Surgical Outcomes This procedure may be indicated for patients who have undergone gallbladder surgery to assess the function of the remaining biliary system.

2. Procedure

The procedure for CPT® Code 78227 involves several critical steps to ensure accurate imaging of the hepatobiliary system. The following outlines the procedural steps:

  • Step 1: Patient Preparation The patient is prepared for the procedure, which may include fasting for a specified period prior to the test to ensure optimal imaging results.
  • Step 2: Intravenous Catheter Placement An intravenous (IV) catheter is placed in the patient's arm to facilitate the administration of the radioactive tracer.
  • Step 3: Injection of Radioactive Tracer The radioactive tracer is injected through the IV catheter. This tracer is designed to be absorbed by the liver and subsequently excreted into the bile.
  • Step 4: Imaging with Gamma Camera A gamma camera is positioned over the patient's abdomen. The camera captures images as the radioactive tracer flows through the bloodstream, highlighting the liver, bile ducts, and gallbladder.
  • Step 5: Continuous Monitoring Throughout the imaging process, the patient is monitored to ensure their comfort and safety. The imaging captures the movement of the tracer from the liver through the biliary system.
  • Step 6: Pharmacologic Intervention During the procedure, additional medications may be administered to enhance gallbladder imaging or stimulate gallbladder contraction, if indicated.
  • Step 7: Gallbladder Ejection Fraction Measurement If necessary, a gallbladder ejection fraction test is performed to quantitatively measure the rate at which bile is released from the gallbladder.
  • Step 8: Image Review and Reporting Upon completion of the imaging, the physician reviews the obtained images and prepares a written report detailing the findings and any abnormalities observed.

3. Post-Procedure

After the completion of the hepatobiliary imaging procedure, the patient may be monitored for a short period to ensure there are no immediate adverse reactions to the radioactive tracer or medications administered. Patients are typically advised to resume normal activities unless otherwise directed by their physician. The results of the imaging study will be compiled into a report, which will be reviewed by the physician to determine any necessary follow-up actions or treatments based on the findings. It is important for patients to discuss the results with their healthcare provider to understand the implications for their health and any further diagnostic or therapeutic steps that may be required.

Short Descr HEPATOBIL SYST IMAGE W/DRUG
Medium Descr HEPATOBIL SYST IMAG INC GB W/PHARMA INTERVENJ
Long Descr Hepatobiliary system imaging, including gallbladder when present; with pharmacologic intervention, including quantitative measurement(s) when performed
Status Code Active Code
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 1 - Diagnostic Tests for Radiology Services
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Not Discounted when Multiple
ASC Payment Indicator Radiology service paid separately when provided integral to a surgical procedure on ASC list; payment based on OPPS relative payment weight.
Type of Service (TOS) 4 - Diagnostic Radiology
Berenson-Eggers TOS (BETOS) I4B - Imaging/procedure - other
MUE 1
CCS Clinical Classification 209 - Radioisotope scan and function studies
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
MH Unknown if ordering professional consulted a clinical decision support mechanism for this service, related information was not provided to the furnishing professional or provider
MG The order for this service does not have applicable appropriate use criteria in the qualified clinical decision support mechanism consulted by the ordering professional
GC This service has been performed in part by a resident under the direction of a teaching physician
ME The order for this service adheres to appropriate use criteria in the clinical decision support mechanism consulted by the ordering professional
TC Technical component; under certain circumstances, a charge may be made for the technical component alone; under those circumstances the technical component charge is identified by adding modifier 'tc' to the usual procedure number; technical component charges are institutional charges and not billed separately by physicians; however, portable x-ray suppliers only bill for technical component and should utilize modifier tc; the charge data from portable x-ray suppliers will then be used to build customary and prevailing profiles
QQ Ordering professional consulted a qualified clinical decision support mechanism for this service and the related data was provided to the furnishing professional
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
GA Waiver of liability statement issued as required by payer policy, individual case
MF The order for this service does not adhere to the appropriate use criteria in the clinical decision support mechanism consulted by the ordering professional
MA Ordering professional is not required to consult a clinical decision support mechanism due to service being rendered to a patient with a suspected or confirmed emergency medical condition
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
AM Physician, team member service
CR Catastrophe/disaster related
ET Emergency services
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
GZ Item or service expected to be denied as not reasonable and necessary
JZ Zero drug amount discarded/not administered to any patient
LT Left side (used to identify procedures performed on the left side of the body)
MB Ordering professional is not required to consult a clinical decision support mechanism due to the significant hardship exception of insufficient internet access
MC Ordering professional is not required to consult a clinical decision support mechanism due to the significant hardship exception of electronic health record or clinical decision support mechanism vendor issues
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
Q5 Service furnished under a reciprocal billing arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
RT Right side (used to identify procedures performed on the right side of the body)
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
XP Separate practitioner, a service that is distinct because it was performed by a different practitioner
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
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2012-01-01 Added Added
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