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Official Description

Myocardial perfusion imaging, planar (including qualitative or quantitative wall motion, ejection fraction by first pass or gated technique, additional quantification, when performed); single study, at rest or stress (exercise or pharmacologic)

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

Myocardial perfusion imaging is a specialized nuclear medicine procedure designed to assess the functionality of the heart muscle and the blood flow to the heart. This diagnostic test involves the use of a radionuclide, commonly referred to as a tracer, which is injected into the patient's bloodstream through an intravenous line placed in a vein, typically in the hand or arm. To monitor the heart's activity during the procedure, electrocardiogram (ECG) leads are attached to the patient's chest, and a blood pressure cuff is positioned on the arm. The patient is then positioned flat on a table within the procedure room. The imaging can be conducted while the patient is at rest or under stress, which can be induced either through physical exercise on a treadmill or stationary bike or through the administration of a pharmacologic agent that simulates the effects of exercise on the heart. During the procedure, the radionuclide circulates through the bloodstream and preferentially accumulates in healthy heart tissue, while ischemic or damaged heart tissue does not absorb the tracer effectively. This differential uptake allows for the creation of planar images of the heart and surrounding great vessels. The physician analyzes these images to evaluate the motion of the heart walls, which is crucial for determining the heart muscle's efficiency in pumping blood throughout the body. A key measurement obtained during this imaging is the ejection fraction, which indicates the percentage of blood that is ejected from the heart with each contraction. This measurement can be derived using either a first pass technique, where images are captured as the radionuclide first circulates through the heart, or a gated technique, which involves taking a series of images in synchronization with the heartbeats to produce high-resolution images. The physician may also perform additional quantification of heart function based on the distribution of the radionuclide, culminating in a comprehensive written report detailing the findings of the study. In the context of CPT® Code 78453, this procedure is classified as a single study conducted either at rest or under stress, distinguishing it from CPT® Code 78454, which encompasses multiple studies performed under similar conditions.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The indications for myocardial perfusion imaging using CPT® Code 78453 include the following:

  • Evaluation of Coronary Artery Disease This procedure is performed to assess the presence and severity of coronary artery disease, which can lead to ischemic heart conditions.
  • Assessment of Myocardial Ischemia Myocardial perfusion imaging helps in identifying areas of the heart that may not be receiving adequate blood flow due to blockages or narrowing of the coronary arteries.
  • Preoperative Assessment It is utilized to evaluate cardiac function in patients undergoing non-cardiac surgery, ensuring that the heart can tolerate the stress of the procedure.
  • Post-Myocardial Infarction Evaluation This imaging technique is used to assess the heart's function and perfusion status following a heart attack.
  • Monitoring of Cardiac Conditions It is also indicated for monitoring patients with known heart disease to evaluate the effectiveness of treatment interventions.

2. Procedure

The procedure for myocardial perfusion imaging as described in CPT® Code 78453 involves several key steps:

  • Preparation of the Patient The patient is prepared for the procedure by placing ECG leads on the chest to monitor heart activity and applying a blood pressure cuff to the arm. An intravenous line is established for the administration of the radionuclide tracer.
  • Administration of Radionuclide A radionuclide, or tracer, is injected into the intravenous line. This tracer is crucial for visualizing blood flow to the heart muscle during the imaging process.
  • Resting or Stress Imaging The imaging can be performed while the patient is at rest or under stress. For stress imaging, the patient may either exercise on a treadmill or stationary bike, or receive a pharmacologic agent that simulates exercise, thereby increasing the heart's workload.
  • Image Acquisition As the radionuclide circulates, planar images of the heart and great vessels are obtained. The imaging captures how well the heart muscle is perfused with blood, highlighting areas of healthy and ischemic tissue.
  • Analysis of Heart Function The physician evaluates the images to assess heart wall motion and calculates the ejection fraction, which indicates the percentage of blood pumped out of the heart. This can be done using either a first pass technique, where images are taken during the initial circulation of the radionuclide, or a gated technique, which synchronizes image capture with the heartbeats for enhanced clarity.
  • Reporting Findings After the imaging is complete, the physician reviews the results, quantifies other parameters of heart function, and prepares a written report detailing the findings of the study.

3. Post-Procedure

Post-procedure care for patients undergoing myocardial perfusion imaging typically involves monitoring for any immediate reactions to the radionuclide injection. Patients are generally advised to hydrate well to help flush the tracer from their system. There are usually no significant restrictions following the procedure, and patients can typically resume normal activities unless otherwise directed by their physician. The physician will discuss the results of the imaging study with the patient during a follow-up appointment, where further management or treatment options may be considered based on the findings.

Short Descr HT MUSCLE IMAGE PLANAR SING
Medium Descr MYOCARDIAL PERFUSION PLANAR 1 STUDY REST/STRESS
Long Descr Myocardial perfusion imaging, planar (including qualitative or quantitative wall motion, ejection fraction by first pass or gated technique, additional quantification, when performed); single study, at rest or stress (exercise or pharmacologic)
Status Code Active Code
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 1 - Diagnostic Tests for Radiology Services
Multiple Procedures (51) 6 - Special payment adjustment rules on the technical component (TC) of multiple diagnostic cardiovascular services apply...
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Not Discounted when Multiple
ASC Payment Indicator Radiology service paid separately when provided integral to a surgical procedure on ASC list; payment based on OPPS relative payment weight.
Type of Service (TOS) 4 - Diagnostic Radiology
Berenson-Eggers TOS (BETOS) I1E - Standard imaging - nuclear medicine
MUE 1
CCS Clinical Classification 209 - Radioisotope scan and function studies
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
GC This service has been performed in part by a resident under the direction of a teaching physician
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
ME The order for this service adheres to appropriate use criteria in the clinical decision support mechanism consulted by the ordering professional
MF The order for this service does not adhere to the appropriate use criteria in the clinical decision support mechanism consulted by the ordering professional
MH Unknown if ordering professional consulted a clinical decision support mechanism for this service, related information was not provided to the furnishing professional or provider
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
QQ Ordering professional consulted a qualified clinical decision support mechanism for this service and the related data was provided to the furnishing professional
TC Technical component; under certain circumstances, a charge may be made for the technical component alone; under those circumstances the technical component charge is identified by adding modifier 'tc' to the usual procedure number; technical component charges are institutional charges and not billed separately by physicians; however, portable x-ray suppliers only bill for technical component and should utilize modifier tc; the charge data from portable x-ray suppliers will then be used to build customary and prevailing profiles
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2011-01-01 Changed Short description changed.
2010-01-01 Added -
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