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The HLA Class I typing, low resolution (CPT® Code 81374) is a laboratory procedure that focuses on identifying specific antigen equivalents within the human leukocyte antigen (HLA) system, which is a critical component of the major histocompatibility complex (MHC). The MHC plays a vital role in the immune system by facilitating self-recognition, allowing the body to distinguish its own cells and tissues from foreign invaders, such as pathogens and nonself cells. The HLA system is located on the short arm of chromosome 6 and is divided into two main classes: Class I and Class II. Among these, Class I is particularly significant, with the most important loci being A, B, and C. Each of these loci can have multiple variants known as alleles, which are designated by a specific nomenclature that includes the locus followed by an asterisk (*) and a series of digits (e.g., HLA-B*27). The identification of HLA alleles is crucial for various medical applications, including organ transplantation, where matching donor and recipient HLA types can significantly reduce the risk of transplant rejection. Additionally, HLA typing is important in understanding susceptibility to certain diseases, including autoimmune disorders and some cancers. The low resolution typing performed under this code specifically identifies antigen equivalents, which are broader categories of alleles rather than individual alleles. This is typically achieved through molecular techniques such as polymerase chain reaction (PCR) sequence specific priming (SSP), which amplifies groups of alleles using specific primer pairs. The low resolution testing can be conducted using specialized test kits or semi-automatic systems, and it is essential for determining the presence of specific Class I antigen equivalents, such as B*27, which can have significant clinical implications.
© Copyright 2025 Coding Ahead. All rights reserved.
The HLA Class I typing, low resolution (CPT® Code 81374) is indicated for various clinical scenarios where understanding an individual's HLA antigen profile is essential. The following conditions and situations may warrant this testing:
The procedure for HLA Class I typing, low resolution, involves several key steps to ensure accurate identification of antigen equivalents. The following procedural steps are typically followed:
After the HLA Class I typing procedure is completed, the results are typically reviewed and interpreted by a qualified healthcare professional. The findings can provide critical information for managing patient care, particularly in the context of organ transplantation and disease susceptibility. Patients may not require specific post-procedure care related to the HLA typing itself, but it is essential for healthcare providers to communicate the results effectively and discuss any implications for treatment or further testing. Additionally, the laboratory may retain samples for a specified period for quality control or further analysis if needed.
| Short Descr | HLA I TYPING 1 ANTIGEN LR | Medium Descr | HLA I LOW RESOLUTION ONE ANTIGEN EQUIVALENT EACH | Long Descr | HLA Class I typing, low resolution (eg, antigen equivalents); one antigen equivalent (eg, B*27), each | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Service Paid under Fee Schedule or Payment System other than OPPS | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 234 - Pathology |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | GA | Waiver of liability statement issued as required by payer policy, individual case | 59 | Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25. | XS | Separate structure, a service that is distinct because it was performed on a separate organ/structure | GZ | Item or service expected to be denied as not reasonable and necessary | 91 | Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient. | GW | Service not related to the hospice patient's terminal condition |
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| 2012-01-01 | Added | Added |
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