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Official Description

Blood count; leukocyte (WBC), automated

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

An automated white blood cell (WBC/leukocyte) count, represented by CPT® Code 85048, is a laboratory procedure that quantifies the number of leukocytes present in a specific volume of blood. This test is crucial for evaluating variations in leukocyte levels, which can indicate various health conditions. The leukocyte count is particularly significant in monitoring patients with conditions such as HIV and AIDS, where the immune system is compromised, leading to potential decreases in WBCs. Additionally, this count is essential for patients undergoing medical therapies like chemotherapy or radiation therapy, which can also result in a reduction of white blood cells. Furthermore, an elevated leukocyte count may signal the presence of bacterial infections, inflammatory responses, leukemia, or trauma. The procedure utilizes an automated blood cell counting instrument, ensuring accuracy and efficiency in obtaining the leukocyte count, which is vital for diagnosing and managing various medical conditions.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The automated leukocyte (WBC) count is indicated for several clinical scenarios, particularly when there is a need to assess the immune system's status or to investigate potential underlying health issues. The following conditions may warrant the performance of this procedure:

  • Monitoring HIV and AIDS - To evaluate the immune system's function and track any changes in leukocyte levels.
  • Monitoring Medical Therapies - To assess the impact of treatments such as chemotherapy or radiation therapy that may lead to a decrease in white blood cell counts.
  • Screening for Infections - To detect elevated leukocyte levels that may indicate bacterial infections or other inflammatory conditions.
  • Evaluating Trauma - To identify potential leukocyte responses to physical injuries or trauma.
  • Assessing Leukemia - To help diagnose and monitor blood cancers characterized by abnormal leukocyte levels.

2. Procedure

The procedure for performing an automated leukocyte count involves several key steps to ensure accurate results. The following outlines the procedural steps:

  • Step 1: Sample Collection - A blood sample is collected from the patient, typically via venipuncture, using a sterile technique to prevent contamination. The sample is usually drawn into a tube containing an anticoagulant to prevent clotting.
  • Step 2: Sample Preparation - The collected blood sample is prepared for analysis. This may involve mixing the sample gently to ensure uniform distribution of cells and may include diluting the sample if necessary, depending on the specific requirements of the automated counting instrument.
  • Step 3: Automated Counting - The prepared blood sample is then placed into an automated blood cell counting instrument. This device uses various technologies, such as impedance or laser-based methods, to count and differentiate the leukocytes present in the sample.
  • Step 4: Data Analysis - The instrument analyzes the data collected and generates a report detailing the total leukocyte count, along with any relevant subtypes of white blood cells, if applicable. This report is then reviewed by a qualified healthcare professional.

3. Post-Procedure

After the automated leukocyte count is performed, the results are typically available within a short timeframe, allowing for prompt clinical decision-making. There are generally no specific post-procedure care requirements for patients, as the blood draw is minimally invasive. However, patients may be advised to apply pressure to the puncture site to minimize any potential bleeding or bruising. The healthcare provider will review the results with the patient, discussing any necessary follow-up actions based on the leukocyte count findings and the patient's overall clinical picture.

Short Descr AUTOMATED LEUKOCYTE COUNT
Medium Descr BLOOD COUNT LEUKOCYTE WBC AUTOMATED
Long Descr Blood count; leukocyte (WBC), automated
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1D - Lab tests - blood counts
MUE 2
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
GA Waiver of liability statement issued as required by payer policy, individual case
AY Item or service furnished to an esrd patient that is not for the treatment of esrd
GW Service not related to the hospice patient's terminal condition
Q4 Service for ordering/referring physician qualifies as a service exemption
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GX Notice of liability issued, voluntary under payer policy
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
GZ Item or service expected to be denied as not reasonable and necessary
KX Requirements specified in the medical policy have been met
Q0 Investigational clinical service provided in a clinical research study that is in an approved clinical research study
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
Date
Action
Notes
2003-01-01 Changed Code description changed.
Pre-1990 Added Code added.
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