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Official Description

Cytopathology, cervical or vaginal (any reporting system), requiring interpretation by physician

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

Cytopathology examination, specifically for cervical or vaginal samples, is a diagnostic procedure aimed at identifying cellular changes that may indicate the presence of disease. This examination is crucial for detecting abnormalities such as cervical dysplasia and in situ carcinoma, which are precursors to invasive malignancies. The procedure is commonly known as a Papanicolaou (PAP) smear, a test that involves collecting cells from the cervix or vagina for microscopic evaluation. After the PAP smear is processed using any reporting system, a pathologist interprets the findings to assess the cellular structure. If the results show any abnormalities, the pathologist may suggest follow-up actions, which could include scheduling another PAP smear sooner than the standard interval or conducting further diagnostic tests like colposcopy, endocervical curettage, or biopsy to ensure comprehensive evaluation and management of potential health issues.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The cytopathology examination using CPT® Code 88141 is indicated for the following conditions:

  • Cervical Dysplasia - This condition involves the presence of abnormal cells on the surface of the cervix, which may indicate a precancerous state.
  • In Situ Carcinoma - This refers to cancer that is confined to the site of origin and has not invaded surrounding tissues, making early detection critical for effective treatment.
  • Monitoring of Abnormal Findings - The procedure is also indicated for patients with previously identified abnormal results who require ongoing surveillance to prevent progression to invasive disease.

2. Procedure

The procedure for cytopathology examination involves several key steps that ensure accurate diagnosis and interpretation of cervical or vaginal samples:

  • Sample Collection - A healthcare provider collects cells from the cervix or vagina using a specialized instrument. This sample is then prepared for analysis, typically through a PAP smear technique.
  • Processing of the Sample - The collected sample is processed using a reporting system, which may include various methods of slide preparation and staining to enhance visibility of cellular structures under a microscope.
  • Microscopic Evaluation - A pathologist examines the prepared slides under a microscope, looking for any cellular abnormalities that may indicate disease. This evaluation is critical for determining the presence of conditions such as dysplasia or carcinoma.
  • Interpretation of Findings - After the microscopic evaluation, the pathologist interprets the results. If any abnormalities are detected, the pathologist will document these findings and may recommend further diagnostic procedures or follow-up tests.

3. Post-Procedure

Post-procedure care following a cytopathology examination typically involves monitoring the patient for any abnormal results. If the findings are abnormal, the pathologist may recommend a follow-up PAP smear at a shorter interval than usual to closely monitor the situation. Additionally, further diagnostic tests such as colposcopy, endocervical curettage, or biopsy may be suggested to obtain more definitive information regarding the cellular changes observed. Patients should be informed about the importance of follow-up appointments and any additional tests that may be necessary to ensure comprehensive care and management of their health.

Short Descr CYTOPATH C/V INTERPRET
Medium Descr CYTP CERVICAL/VAGINAL REQ INTERP PHYSICIAN
Long Descr Cytopathology, cervical or vaginal (any reporting system), requiring interpretation by physician
Status Code Active Code
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 2 - Professional Component Only Code
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1G - Lab tests - other (Medicare fee schedule)
MUE 1
CCS Clinical Classification 234 - Pathology

This is a primary code that can be used with these additional add-on codes.

0831T Add On Code Resequenced Code MPFS Status: Carrier Priced APC N Digitization of glass microscope slides for cytopathology, cervical or vaginal (any reporting system), requiring interpretation by physician (List separately in addition to code for primary procedure)
GC This service has been performed in part by a resident under the direction of a teaching physician
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
GA Waiver of liability statement issued as required by payer policy, individual case
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
GZ Item or service expected to be denied as not reasonable and necessary
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
CR Catastrophe/disaster related
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
KX Requirements specified in the medical policy have been met
LT Left side (used to identify procedures performed on the left side of the body)
PA Surgical or other invasive procedure on wrong body part
PD Diagnostic or related non diagnostic item or service provided in a wholly owned or operated entity to a patient who is admitted as an inpatient within 3 days
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
QC Single channel monitoring
RT Right side (used to identify procedures performed on the right side of the body)
X1 Continuous/broad services: for reporting services by clinicians, who provide the principal care for a patient, with no planned endpoint of the relationship; services in this category represent comprehensive care, dealing with the entire scope of patient problems, either directly or in a care coordination role; reporting clinician service examples include, but are not limited to: primary care, and clinicians providing comprehensive care to patients in addition to specialty care
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
XP Separate practitioner, a service that is distinct because it was performed by a different practitioner
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
Date
Action
Notes
2024-01-01 Changed Guideline information changed.
2011-01-01 Changed Short description changed.
2006-01-01 Changed Code description changed.
2005-01-01 Changed Code description changed.
1998-01-01 Added First appearance in code book in 1998.
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