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Flow cytometry, cell cycle or DNA analysis, as described by CPT® Code 88182, is a sophisticated laboratory test that employs flow cytometry technology to analyze the cell cycle or DNA content of various cell types. This procedure involves the use of fluorescent dyes that specifically bind to DNA, allowing for the visualization and quantification of cells within a sample. The samples can be derived from a variety of sources, including tissue tumors, body fluids, blood, bone marrow, and urine or bladder washings. Once the cells are stained, they are suspended in a fluid stream and passed through an automated detector. This process generates a DNA histogram or cell cycle profile, which is instrumental in assessing the prognosis of malignant tumors and evaluating products of conception for conditions such as hydatidiform mole. The flow cytometry technique enables the counting and sorting of cells based on specific biomarkers, facilitating the differentiation between normal and tumor cells. It is important to note that the sample for this analysis must be obtained through a separately reportable procedure, and the findings are documented in a written report that details the results of the analysis.
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The flow cytometry, cell cycle or DNA analysis procedure is indicated for several specific clinical scenarios, particularly in the evaluation of malignancies and reproductive health. The following conditions warrant the use of this laboratory test:
The procedure for flow cytometry, cell cycle or DNA analysis involves several key steps that ensure accurate and reliable results. Each step is crucial for the successful execution of the test:
Post-procedure care following flow cytometry, cell cycle or DNA analysis typically involves reviewing the written report generated from the test. Healthcare providers will interpret the findings to determine the next steps in patient management. Depending on the results, further diagnostic testing or treatment options may be considered. It is important for clinicians to communicate the results to the patient and discuss any necessary follow-up actions. Additionally, the laboratory may retain the sample for a specified period in case further analysis is required.
| Short Descr | CELL MARKER STUDY | Medium Descr | FLOW CYTOMETRY CELL CYCLE/DNA ANALYSIS | Long Descr | Flow cytometry, cell cycle or DNA analysis | Status Code | Active Code | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 1 - Diagnostic Tests for Radiology Services | Multiple Procedures (51) | 0 - No payment adjustment rules for multiple procedures apply. | Bilateral Surgery (50) | 0 - 150% payment adjustment for bilateral procedures does NOT apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 0 - Payment restriction for assistants at surgery applies to this procedure... | Co-Surgeons (62) | 0 - Co-surgeons not permitted for this procedure. | Team Surgery (66) | 0 - Team surgeons not permitted for this procedure. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | APC Status Indicator | T-Packaged Codes | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1G - Lab tests - other (Medicare fee schedule) | MUE | 2 | CCS Clinical Classification | 234 - Pathology |
| 26 | Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number. | GC | This service has been performed in part by a resident under the direction of a teaching physician | XU | Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service | 59 | Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25. | 76 | Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service. | 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | Q1 | Routine clinical service provided in a clinical research study that is in an approved clinical research study | TC | Technical component; under certain circumstances, a charge may be made for the technical component alone; under those circumstances the technical component charge is identified by adding modifier 'tc' to the usual procedure number; technical component charges are institutional charges and not billed separately by physicians; however, portable x-ray suppliers only bill for technical component and should utilize modifier tc; the charge data from portable x-ray suppliers will then be used to build customary and prevailing profiles | XS | Separate structure, a service that is distinct because it was performed on a separate organ/structure |
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| 2013-01-01 | Changed | Medium Descriptor changed. |
| 2006-01-01 | Changed | Code description changed. |
| Pre-1990 | Added | Code added. |
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