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Morphometric analysis, in situ hybridization (quantitative or semi-quantitative) is a specialized laboratory technique employed by pathologists and geneticists to visualize and analyze specific genes or segments of genes within cells. This method utilizes fluorescent tagging to detect genetic abnormalities, which may include translocations, deletions, duplications, amplifications, and inversions on chromosomes, as well as in hematologic cells and solid tumors. The process begins with fixing cells onto a slide, followed by treatment to denature the DNA, converting it into single strands. A short sequence of single-stranded DNA, known as a probe, is designed to match a specific target gene or genes and is tagged with fluorescent labels. This probe is then applied to the slide, where it hybridizes, or binds, to the complementary DNA strands. After hybridization, the slide undergoes washing to eliminate any unbound probe, ensuring that only specific interactions are detected. The final analysis is conducted using computer-assisted technology, which allows for precise identification and interpretation of any genetic abnormalities present. The CPT® Code 88373 is specifically designated for reporting each additional single probe stain procedure performed in conjunction with the primary procedure, which is reported using 88367. In cases where multiple probes are utilized simultaneously within the same staining procedure, the appropriate code to report is 88374.
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The morphometric analysis, in situ hybridization (quantitative or semi-quantitative) procedure is indicated for the following conditions:
The procedure for morphometric analysis, in situ hybridization involves several key steps:
Post-procedure care for morphometric analysis, in situ hybridization typically involves ensuring that the results are accurately documented and communicated to the relevant healthcare providers. The analysis may require further interpretation by a pathologist or geneticist, who will integrate the findings with clinical information to guide treatment decisions. Additionally, any necessary follow-up testing or monitoring should be planned based on the results obtained from the procedure. It is important to maintain proper records of the procedure and results for compliance and future reference.
| Short Descr | M/PHMTRC ALYS ISHQUANT/SEMIQ | Medium Descr | M/PHMTRC ALYS ISH QUANT/SEMIQ CPTR PER SPEC EACH | Long Descr | Morphometric analysis, in situ hybridization (quantitative or semi-quantitative), using computer-assisted technology, per specimen; each additional single probe stain procedure (List separately in addition to code for primary procedure) | Status Code | Active Code | Global Days | ZZZ - Code Related to Another Service | PC/TC Indicator (26, TC) | 1 - Diagnostic Tests for Radiology Services | Multiple Procedures (51) | 0 - No payment adjustment rules for multiple procedures apply. | Bilateral Surgery (50) | 0 - 150% payment adjustment for bilateral procedures does NOT apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 0 - Payment restriction for assistants at surgery applies to this procedure... | Co-Surgeons (62) | 0 - Co-surgeons not permitted for this procedure. | Team Surgery (66) | 0 - Team surgeons not permitted for this procedure. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | APC Status Indicator | Items and Services Packaged into APC Rates | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1G - Lab tests - other (Medicare fee schedule) | MUE | 3 |
This is an add-on code that must be used in conjunction with one of these primary codes.
| 88367 | MPFS Status: Active Code APC Q2 PUB 100 CPT Assistant Article Morphometric analysis, in situ hybridization (quantitative or semi-quantitative), using computer-assisted technology, per specimen; initial single probe stain procedure |
| 59 | Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25. | 26 | Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number. | 76 | Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service. | 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | GC | This service has been performed in part by a resident under the direction of a teaching physician | GW | Service not related to the hospice patient's terminal condition | GZ | Item or service expected to be denied as not reasonable and necessary | TC | Technical component; under certain circumstances, a charge may be made for the technical component alone; under those circumstances the technical component charge is identified by adding modifier 'tc' to the usual procedure number; technical component charges are institutional charges and not billed separately by physicians; however, portable x-ray suppliers only bill for technical component and should utilize modifier tc; the charge data from portable x-ray suppliers will then be used to build customary and prevailing profiles | X5 | Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician | XU | Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service |
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| 2015-01-01 | Added | Added |
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