CPT® Code 90281

1. Indications

Immune globulin (Ig) is indicated for use in various clinical scenarios where passive immunity is required. The following conditions may warrant the administration of immune globulin:

• Post-exposure prophylaxis for individuals who have been exposed to certain infectious diseases, such as hepatitis A or measles, to prevent the onset of illness.
• Immunodeficiency disorders in patients who have compromised immune systems, where additional antibodies are necessary to help fight infections.
• Autoimmune disorders where immune globulin may be used to modulate the immune response and reduce the severity of symptoms.

2. Procedure

The administration of immune globulin (Ig) via intramuscular injection involves several key procedural steps to ensure safety and efficacy. The following outlines the procedure:

• Step 1: Patient Assessment Before administering immune globulin, a thorough assessment of the patient’s medical history and current health status is conducted. This includes evaluating any previous reactions to immune globulin products and determining the appropriateness of the treatment based on the indications.
• Step 2: Preparation of the Product The immune globulin product is prepared according to the manufacturer's instructions. This may involve allowing the solution to reach room temperature and gently mixing it to ensure homogeneity. Proper aseptic techniques are employed to maintain sterility during preparation.
• Step 3: Administration The immune globulin is administered intramuscularly, typically in the deltoid muscle or another suitable site. The injection site is cleaned with an antiseptic solution, and a sterile needle is used to inject the solution. The dosage is determined based on the specific clinical indication and patient factors.
• Step 4: Monitoring After administration, the patient is monitored for any immediate adverse reactions or side effects. This includes observing for signs of allergic reactions or other complications that may arise from the injection.

3. Post-Procedure

Following the administration of immune globulin, patients are typically advised to rest and may be monitored for a short period to ensure there are no immediate adverse effects. It is important to provide patients with information regarding potential side effects, which may include mild fever, headache, or local reactions at the injection site. Patients should be instructed to report any unusual symptoms or reactions that occur after the procedure. Additionally, follow-up appointments may be scheduled to assess the effectiveness of the treatment and to determine if further doses are necessary based on the clinical situation.