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Official Description

Influenza virus vaccine, quadrivalent (qIRV), mRNA; 60 mcg/0.5 mL dosage, for intramuscular use

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90638 refers to a specific formulation of the influenza virus vaccine, which is classified as a quadrivalent mRNA vaccine. This vaccine is designed to provide immunity against influenza diseases caused by two subtypes of influenza A viruses and two types of influenza B viruses that are included in the vaccine composition. The term "quadrivalent" indicates that the vaccine targets four different strains of the influenza virus, enhancing its effectiveness in preventing influenza infections during the flu season. The use of messenger RNA (mRNA) technology in this vaccine represents a significant advancement in vaccine development. Unlike traditional vaccines that may use inactivated or weakened forms of the virus, mRNA vaccines utilize synthetic mRNA that encodes a portion of the viral protein. This approach stimulates the immune system to recognize and respond to the virus without exposing the individual to the actual virus itself. One of the key advantages of mRNA vaccines is their ability to be rapidly adapted to match the circulating strains of influenza, which can vary from year to year. This flexibility allows for a more timely and effective response to emerging influenza strains, potentially leading to higher vaccination efficacy. The specific dosage for CPT® Code 90638 is 60 mcg per 0.5 mL, intended for intramuscular use. It is important to note that the administration of the vaccine is reported separately, and for a lower dosage of 30 mcg per 0.5 mL, CPT® Code 90637 should be used.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The quadrivalent influenza virus vaccine, as represented by CPT® Code 90638, is indicated for the prevention of influenza disease caused by the specific strains of influenza A and B viruses included in the vaccine formulation. The vaccine is particularly recommended for individuals who are at higher risk of influenza-related complications, including but not limited to:

  • High-Risk Populations: Individuals with chronic health conditions, such as asthma, diabetes, or heart disease, who may experience severe illness if infected with the influenza virus.
  • Older Adults: Individuals aged 65 years and older, who are more susceptible to severe influenza complications.
  • Healthcare Workers: Those who work in healthcare settings and are at increased risk of exposure to influenza viruses.
  • Pregnant Women: Pregnant individuals, as they are at higher risk for severe illness from influenza and can also pass immunity to their newborns.

2. Procedure

The administration of the quadrivalent influenza virus vaccine (CPT® Code 90638) involves several key procedural steps to ensure proper delivery and effectiveness of the vaccine:

  • Step 1: Preparation of the Vaccine The vaccine should be prepared according to the manufacturer's instructions. This includes checking the expiration date, ensuring the vaccine is stored at the correct temperature, and gently mixing the vaccine if required to ensure uniformity.
  • Step 2: Patient Assessment Prior to administration, a thorough assessment of the patient’s medical history should be conducted. This includes checking for any contraindications to the vaccine, such as severe allergies to components of the vaccine or a history of Guillain-Barré syndrome following a previous influenza vaccination.
  • Step 3: Administration The vaccine is administered intramuscularly, typically in the deltoid muscle of the upper arm for adults and older children, or in the anterolateral thigh for infants and young children. The injection site should be cleaned with an alcohol swab before administration.
  • Step 4: Post-Administration Monitoring After the vaccine is administered, the patient should be monitored for a short period (usually 15 minutes) for any immediate adverse reactions, such as allergic responses. This is particularly important for individuals with a history of allergies.

3. Post-Procedure

Following the administration of the quadrivalent influenza virus vaccine, patients may experience mild side effects, which are generally self-limiting. Common post-procedure care includes advising the patient to rest and hydrate adequately. Patients should be informed about potential side effects, such as soreness at the injection site, low-grade fever, or fatigue, which typically resolve within a few days. It is also important to instruct patients to seek medical attention if they experience any severe or unusual symptoms following vaccination. Additionally, patients should be encouraged to receive the vaccine annually, as influenza strains can change from season to season, necessitating updated vaccinations for optimal protection.

Short Descr VACC QIRV MRNA 60MCG/.5ML IM
Medium Descr VACCINE QIRV MRNA 60 MCG/0.5 ML FOR IM USE
Long Descr Influenza virus vaccine, quadrivalent (qIRV), mRNA; 60 mcg/0.5 mL dosage, for intramuscular use
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Non-Covered Service, not paid under OPPS
Berenson-Eggers TOS (BETOS) none
MUE 1
Date
Action
Notes
2025-01-01 Added First appearance in codebook.
2024-07-01 Added Code added.
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