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Official Description

Rotavirus vaccine, pentavalent (RV5), 3 dose schedule, live, for oral use

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90680 refers to the pentavalent Rotavirus vaccine (RV5), which is administered in a 3-dose schedule and is intended for oral use. Vaccines, unlike immune globulins that provide short-term, passive immunity, are designed to confer active, long-term immunity. This is achieved by introducing altered versions of specific viruses or bacteria into the recipient's immune system, prompting it to produce its own antibodies against these pathogens. The immune system retains a memory of how to produce these antibodies, enabling a quicker and more effective response upon subsequent exposures to the same antigens. Rotavirus is a highly contagious virus that significantly impacts children, with nearly every child in the United States being affected by the age of 5. The disease is characterized by repeated episodes of vomiting and severe diarrhea, which can lead to dehydration and hospitalization. The live, pentavalent Rotavirus vaccine (RV5) contains the live virus and is specifically formulated for oral administration, following a 3-dose schedule to ensure adequate immune response. It is important to note that this code specifically reports the vaccine product used, rather than the administration of the vaccine itself.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The pentavalent Rotavirus vaccine (RV5) is indicated for the prevention of rotavirus disease in infants and young children. The following conditions highlight the necessity for vaccination:

  • Prevention of Rotavirus Disease The vaccine is specifically designed to protect against rotavirus, which is known to cause severe gastrointestinal illness characterized by vomiting and diarrhea in children.
  • High Contagion Risk Given that rotavirus is highly contagious, vaccination is crucial to reduce the incidence of infection among children, particularly those under the age of 5, who are most vulnerable.
  • Hospitalization Prevention The vaccine aims to decrease the risk of hospitalization due to severe dehydration and complications arising from rotavirus infection.

2. Procedure

The administration of the pentavalent Rotavirus vaccine (RV5) follows a structured procedure to ensure effective immunization. The steps involved in the vaccination process are as follows:

  • Step 1: Preparation Prior to administration, the healthcare provider must ensure that the vaccine is stored correctly and is at the appropriate temperature. The vaccine should be visually inspected for any particulate matter or discoloration before use.
  • Step 2: Administration The vaccine is administered orally. The healthcare provider will typically use a syringe or a dropper to deliver the vaccine directly into the infant's mouth, ensuring that the child swallows the vaccine to achieve the desired immune response.
  • Step 3: Scheduling The vaccine is given in a 3-dose schedule, with the first dose typically administered at 2 months of age, followed by the second dose at 4 months, and the third dose at 6 months. Adhering to this schedule is essential for optimal immunity development.

3. Post-Procedure

After the administration of the pentavalent Rotavirus vaccine (RV5), the child may be monitored for a short period to observe for any immediate adverse reactions, although serious side effects are rare. Parents or guardians should be informed about potential mild side effects, such as irritability or mild gastrointestinal symptoms, which may occur as the child's immune system responds to the vaccine. It is also important to ensure that the child completes the full 3-dose schedule to achieve maximum protection against rotavirus disease. Follow-up appointments should be scheduled to administer subsequent doses as per the recommended timeline.

Short Descr RV5 VACC 3 DOSE LIVE ORAL
Medium Descr RV5 VACCINE 3 DOSE SCHEDULE LIVE FOR ORAL USE
Long Descr Rotavirus vaccine, pentavalent (RV5), 3 dose schedule, live, for oral use
Status Code Excluded from Physician Fee Schedule by Regulation
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Non-Covered Service, not paid under OPPS
ASC Payment Indicator
Type of Service (TOS) 1 - Medical Care
Berenson-Eggers TOS (BETOS) O1G - Immunizations/Vaccinations
MUE 1
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
GZ Item or service expected to be denied as not reasonable and necessary
Date
Action
Notes
2016-01-01 Changed First appearance of change in codebook.
2015-07-01 Changed Description Changed
2011-01-01 Changed Short description changed.
2006-01-01 Changed Code description changed.
1999-01-01 Added First appearance in code book in 1999.
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