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Official Description

Respiratory syncytial virus vaccine, mRNA lipid nanoparticles, for intramuscular use

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90683 refers to the respiratory syncytial virus (RSV) vaccine, which utilizes mRNA lipid nanoparticles for intramuscular administration. This vaccine is designed to provide active and long-term immunity by introducing a modified version of the RSV to the recipient's immune system. The process involves the immune system recognizing the altered virus, which prompts the production of specific antibodies that can combat the actual virus upon future exposure. RSV is a highly contagious virus that primarily affects infants, young children, and vulnerable populations such as the elderly, immunocompromised individuals, and those with pre-existing health conditions like diabetes, congestive heart failure, asthma, or chronic obstructive pulmonary disease (COPD). Infection with RSV can lead to severe respiratory illnesses, including pneumonia, which may necessitate hospitalization and can be fatal. The mRNA lipid nanoparticle-based vaccine works by expressing a chemically modified form of the RSV prefusion F glycoprotein, which is crucial for the virus's entry into host cells. This genetic material is encapsulated within a protective lipid nanoparticle, ensuring its safe delivery into the host cells. Once inside, the mRNA instructs the cells to produce the antigen protein, triggering an immune response that results in the production of antibodies. This mechanism not only provides a robust immune response but also ensures that the immunity generated is both safe and long-lasting, particularly beneficial for children and adults alike. It is important to note that this code specifically reports the vaccine product itself and does not encompass the administration of the vaccine via intramuscular injection.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The respiratory syncytial virus vaccine (CPT® Code 90683) is indicated for the prevention of respiratory syncytial virus infections, particularly in populations at higher risk. The following conditions and demographics are explicitly recognized for vaccination:

  • Infants and Young Children: The vaccine is primarily aimed at protecting infants and young children who are particularly susceptible to RSV infections.
  • Older Adults: Individuals in older age groups, who may have weakened immune systems or other health issues, are also at risk and can benefit from vaccination.
  • Immunocompromised Individuals: Those with compromised immune systems due to various medical conditions or treatments are advised to receive the vaccine to reduce the risk of severe RSV infection.
  • Individuals with Chronic Conditions: Patients with underlying health conditions such as diabetes, congestive heart failure, asthma, or chronic obstructive pulmonary disease (COPD) are at increased risk for complications from RSV and are recommended to be vaccinated.

2. Procedure

The administration of the respiratory syncytial virus vaccine involves several key procedural steps, which are outlined as follows:

  • Step 1: Preparation of the Vaccine The vaccine must be prepared according to the manufacturer's guidelines, ensuring that it is stored at the appropriate temperature and is not expired. This includes checking the vial for any visible particles or discoloration before use.
  • Step 2: Patient Assessment Prior to administration, a thorough assessment of the patient’s medical history is conducted to confirm eligibility for vaccination. This includes reviewing any allergies, previous reactions to vaccines, and current health status.
  • Step 3: Administration of the Vaccine The vaccine is administered intramuscularly, typically in the deltoid muscle of the upper arm for adults and older children, or in the anterolateral thigh for infants and young children. The injection site is cleaned with an antiseptic wipe to minimize the risk of infection.
  • Step 4: Post-Administration Monitoring After the vaccine is administered, the patient is monitored for a short period to observe for any immediate adverse reactions. This is particularly important for individuals with a history of allergic reactions to vaccines.

3. Post-Procedure

Following the administration of the respiratory syncytial virus vaccine, patients are advised on post-procedure care and what to expect. Commonly, mild side effects such as soreness at the injection site, low-grade fever, or fatigue may occur, which typically resolve within a few days. Patients should be informed to report any unusual or severe reactions, such as difficulty breathing or swelling, to their healthcare provider immediately. Additionally, it is recommended that patients keep a record of their vaccination for future reference and follow up with their healthcare provider for any necessary booster doses or additional vaccinations as per public health guidelines.

Short Descr RSV VACC MRNA LIPID NANO IM
Medium Descr RSV VACCINE MRNA LIPID NANOPARTICLES FOR IM USE
Long Descr Respiratory syncytial virus vaccine, mRNA lipid nanoparticles, for intramuscular use
Status Code Non-Covered Service
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Not Billable to the MAC
Type of Service (TOS) 1 - Medical Care
Berenson-Eggers TOS (BETOS) none
MUE 1
Date
Action
Notes
2025-01-01 Added First appearance in codebook.
2024-05-31 Note FDA approval granted.
2024-01-01 Added Code added. Effective upon receiving emergency Use Authorization or approval from the FDA.
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