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Official Description

Typhoid vaccine, live, oral

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90690 refers to the live oral typhoid vaccine, which is designed to provide active immunity against typhoid fever. Unlike immune globulins that offer short-term, passive immunity, vaccines like this one stimulate the recipient's immune system to develop its own long-lasting defense. This is achieved by introducing altered forms of the Salmonella typhi bacteria, the pathogen responsible for typhoid fever, into the body. The immune system responds by producing antibodies specifically targeted at these altered versions of the bacteria. Once the immune system has been exposed to the vaccine, it retains a memory of how to produce these antibodies, enabling a quicker and more effective response if the individual encounters the actual bacteria in the future. Typhoid fever is characterized by symptoms such as high fever, rash, and diarrhea, and it is primarily transmitted through contaminated food, water, and milk. The use of CPT® Code 90690 specifically indicates the administration of the oral vaccine that contains the live, attenuated strain of the virus, distinguishing it from other typhoid vaccines, such as the Vi capsular polysaccharide vaccine, which is administered via intramuscular injection and is represented by CPT® Code 90691. It is important to note that these codes are utilized solely to report the specific vaccine product administered.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The live oral typhoid vaccine, represented by CPT® Code 90690, is indicated for individuals who are at risk of contracting typhoid fever. This includes:

  • Travelers to Endemic Areas Individuals traveling to regions where typhoid fever is common, particularly in developing countries with inadequate sanitation and hygiene practices.
  • Individuals in Close Contact with Infected Persons Those who may be in close contact with individuals diagnosed with typhoid fever, thereby increasing their risk of exposure to the bacteria.
  • Laboratory Personnel Healthcare workers and laboratory personnel who handle Salmonella typhi cultures or specimens, as they may be at higher risk of infection.

2. Procedure

The administration of the live oral typhoid vaccine involves several key procedural steps:

  • Step 1: Patient Assessment Prior to vaccination, a thorough assessment of the patient's medical history and current health status is conducted to ensure they are suitable candidates for the vaccine. This includes evaluating any previous vaccinations, allergies, and potential contraindications.
  • Step 2: Vaccine Preparation The vaccine is prepared according to the manufacturer's instructions. This may involve ensuring that the vaccine is stored at the correct temperature and is within its expiration date before administration.
  • Step 3: Administration of the Vaccine The vaccine is administered orally, typically in the form of a capsule. Patients are instructed to take the capsule with a full glass of water, and it is important that they do not chew or crush the capsule to ensure proper delivery of the live attenuated bacteria.
  • Step 4: Post-Administration Monitoring After administration, patients are monitored for a short period to observe for any immediate adverse reactions. They are also provided with information regarding potential side effects and the importance of completing the vaccination series if required.

3. Post-Procedure

Following the administration of the live oral typhoid vaccine, patients may experience mild side effects, such as gastrointestinal discomfort, fever, or rash. These symptoms are generally self-limiting and resolve without intervention. Patients are advised to maintain hydration and report any severe or persistent symptoms to their healthcare provider. It is also important for patients to understand that the vaccine may not provide immediate immunity and that they should continue to practice safe food and water consumption, especially when traveling to endemic areas. Additionally, patients should be informed about the need for booster doses as recommended, depending on their risk factors and the duration of their travel or exposure to endemic regions.

Short Descr TYPHOID VACCINE ORAL
Medium Descr TYPHOID VACCINE LIVE ORAL
Long Descr Typhoid vaccine, live, oral
Status Code Excluded from Physician Fee Schedule by Regulation
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
ASC Payment Indicator Packaged service/item; no separate payment made.
Type of Service (TOS) 1 - Medical Care
Berenson-Eggers TOS (BETOS) O1G - Immunizations/Vaccinations
MUE 1
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
25 Significant, separately identifiable evaluation and management service by the same physician or other qualified health care professional on the same day of the procedure or other service: it may be necessary to indicate that on the day a procedure or service identified by a cpt code was performed, the patient's condition required a significant, separately identifiable e/m service above and beyond the other service provided or beyond the usual preoperative and postoperative care associated with the procedure that was performed. a significant, separately identifiable e/m service is defined or substantiated by documentation that satisfies the relevant criteria for the respective e/m service to be reported (see evaluation and management services guidelines for instructions on determining level of e/m service). the e/m service may be prompted by the symptom or condition for which the procedure and/or service was provided. as such, different diagnoses are not required for reporting of the e/m services on the same date. this circumstance may be reported by adding modifier 25 to the appropriate level of e/m service. note: this modifier is not used to report an e/m service that resulted in a decision to perform surgery. see modifier 57 for significant, separately identifiable non-e/m services, see modifier 59.
CR Catastrophe/disaster related
FQ The service was furnished using audio-only communication technology
GA Waiver of liability statement issued as required by payer policy, individual case
GX Notice of liability issued, voluntary under payer policy
GZ Item or service expected to be denied as not reasonable and necessary
TW Back-up equipment
UC Medicaid level of care 12, as defined by each state
Date
Action
Notes
2011-01-01 Changed Short description changed.
1999-01-01 Added First appearance in code book in 1999.
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