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Official Description

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]) vaccine, mRNA-LNP, spike protein, 3 mcg/0.3 mL dosage, tris-sucrose formulation, for intramuscular use

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 91318 refers to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine, specifically designed to combat coronavirus disease (COVID-19). This vaccine utilizes a formulation of messenger RNA (mRNA) encapsulated in lipid nanoparticles (LNP), which is a method that allows the mRNA to be effectively delivered into human cells. The vaccine contains a dosage of 3 mcg in a 0.3 mL volume and is specifically formulated with tris-sucrose to enhance stability and maintain the appropriate pH for storage at refrigerator temperatures. The mRNA included in this vaccine corresponds to the spike protein of the virus, which is a critical component that the immune system recognizes as foreign. Upon administration, the body’s cells utilize the mRNA to produce copies of the spike protein, prompting an immune response that generates antibodies. These antibodies are essential for recognizing and neutralizing the virus if the individual is exposed post-vaccination. This particular code is designated for the supply of the Pfizer pediatric vaccine, intended for children aged 6 months through 4 years, and it is important to note that the administration of the vaccine is reported separately from the supply code itself.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The CPT® Code 91318 is indicated for the vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease (COVID-19). The vaccine is specifically designed for use in pediatric patients aged 6 months through 4 years. It is intended to provide protection against the potentially severe and life-threatening effects of COVID-19, particularly in young children who may be at risk for serious illness from the virus.

  • COVID-19 Prevention The vaccine is administered to prevent infection by the SARS-CoV-2 virus and to mitigate the risk of severe disease associated with COVID-19 in young children.

2. Procedure

The administration of the vaccine involves several key procedural steps to ensure safety and efficacy. First, the vaccine must be prepared by diluting the Pfizer pediatric vaccine with normal saline to achieve the correct dosage of 3 mcg in a 0.3 mL volume. This preparation is crucial for ensuring that the vaccine is safe and effective for the target age group. Next, the healthcare provider will select an appropriate site for intramuscular injection, typically in the thigh for infants and young children. The injection site should be cleaned with an antiseptic to minimize the risk of infection. Once the site is prepared, the vaccine is administered intramuscularly, allowing the lipid nanoparticles to facilitate the uptake of mRNA by the cells. After the injection, the healthcare provider may observe the patient for a short period to monitor for any immediate adverse reactions. It is important to document the administration details, including the date, time, and site of injection, as well as any reactions observed during the monitoring period.

  • Step 1: Vaccine Preparation The vaccine is prepared by diluting the Pfizer pediatric vaccine with normal saline to achieve the appropriate dosage of 3 mcg in a 0.3 mL volume.
  • Step 2: Site Selection and Preparation An appropriate site for intramuscular injection is selected, typically the thigh, and the site is cleaned with an antiseptic.
  • Step 3: Vaccine Administration The vaccine is administered intramuscularly, allowing the lipid nanoparticles to facilitate the uptake of mRNA by the cells.
  • Step 4: Post-Administration Monitoring The patient is observed for a short period to monitor for any immediate adverse reactions, and documentation of the administration details is completed.

3. Post-Procedure

After the administration of the vaccine, it is essential to monitor the patient for any immediate side effects or adverse reactions, which may include mild symptoms such as soreness at the injection site, fever, or fatigue. These reactions are typically short-lived and resolve on their own. Parents or guardians should be informed about potential side effects and advised on when to seek medical attention. Additionally, it is important to schedule any follow-up doses if required, as per the vaccination schedule recommended for the pediatric population. Documentation of the vaccination, including the lot number and expiration date of the vaccine, should be recorded in the patient's medical record to ensure proper tracking and compliance with vaccination protocols.

Short Descr SARSCOV2 VAC 3MCG TRS-SUC IM
Medium Descr SARSCOV2 VACC 3MCG/0.3ML TRIS-SUCROSE IM USE
Long Descr Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease [COVID-19]) vaccine, mRNA-LNP, spike protein, 3 mcg/0.3 mL dosage, tris-sucrose formulation, for intramuscular use
Related Drugs Pfizer-BioNTech Covid-19 Vaccine
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Influenza, Pneumococcal Pneumonia, Hepatitis B, and Covid-19 Vaccines; Monoclonal Antibody Therapy Product
Berenson-Eggers TOS (BETOS) none
MUE 1
Date
Action
Notes
2025-01-01 Added First appearance of code and guideline in codebook
2023-09-11 Added FDA approval received
2023-09-11 Note AMA Guideline changed. 90480 received FDA approval
2023-09-08 Note Technical correction.
2023-08-14 Added Code added, effective upon receiving Emergency Use Authorization or approval from the Food and Drug Administration
2023-08-14 Note AMA guideline code 90480 published to AMA website. Effective upon receiving emergency Use Authorization or approval from the FDA.
Code
Description
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