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Official Description

Refilling and maintenance of portable pump

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 96521 refers to the process of refilling and maintaining a portable pump that is utilized for the prolonged infusion of various therapeutic agents, including chemotherapy drugs, monoclonal antibodies, biologic response modifiers, and other antineoplastic substances. Prolonged infusion is specifically characterized as the administration of these substances over a duration exceeding eight hours. The portable pump is filled with a predetermined quantity of the medication, which is often complex in nature, and is programmed to deliver this medication continuously throughout the specified infusion period. It is essential to regularly check the functionality of the pump to ensure that it is operating correctly and that the medication is being dispensed as intended. For external portable pumps, the appropriate code to use is 96521, while 96522 should be used for implantable pumps or reservoirs.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The procedure associated with CPT® Code 96521 is indicated for patients requiring prolonged infusion of specific therapeutic agents. The following conditions or situations may warrant the use of this procedure:

  • Chemotherapy Administration Patients undergoing treatment for cancer may require continuous infusion of chemotherapy drugs to effectively manage their condition.
  • Monoclonal Antibody Therapy Individuals receiving monoclonal antibodies for various diseases, including certain cancers and autoimmune disorders, may benefit from prolonged infusion via a portable pump.
  • Biologic Response Modifiers Patients needing biologic response modifiers, which can enhance the body's immune response, may also be candidates for this procedure.
  • Antineoplastic Substances The use of other antineoplastic agents that require extended infusion times can necessitate the refilling and maintenance of a portable pump.

2. Procedure

The procedure for refilling and maintaining a portable pump involves several critical steps to ensure the safe and effective delivery of medication. Each step is essential for the proper functioning of the pump and the successful administration of the therapeutic agent.

  • Step 1: Preparation The healthcare provider prepares the necessary equipment and medication for the refill process. This includes gathering the appropriate chemotherapy drug or biologic agent, ensuring that it is the correct dosage as prescribed by the physician.
  • Step 2: Pump Inspection Before refilling, the provider inspects the portable pump to verify that it is functioning correctly. This includes checking for any signs of malfunction or blockage that could impede drug delivery.
  • Step 3: Refilling the Pump The provider carefully fills the pump with the prescribed amount of medication. This step requires precision to ensure that the correct dosage is administered, as well as adherence to safety protocols to prevent contamination.
  • Step 4: Programming the Pump After refilling, the pump is programmed to deliver the medication continuously over the specified prolonged period. The provider sets the infusion rate according to the treatment plan established by the physician.
  • Step 5: Final Checks Once the pump is filled and programmed, the provider conducts final checks to confirm that the pump is operating as intended. This includes monitoring the flow rate and ensuring that the medication is being delivered properly.

3. Post-Procedure

After the procedure, the patient may be monitored for any immediate reactions to the medication. It is important to provide the patient with instructions regarding the care and maintenance of the portable pump, including how to recognize signs of malfunction or complications. Patients should be advised to report any issues, such as pain, swelling, or unusual symptoms, to their healthcare provider promptly. Regular follow-up appointments may be necessary to assess the effectiveness of the treatment and to perform additional refills as required.

Short Descr REFILL/MAINT PORTABLE PUMP
Medium Descr REFILLING & MAINTENANCE PORTABLE PUMP
Long Descr Refilling and maintenance of portable pump
Status Code Active Code
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 5 - Incident To Code
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Not Discounted when Multiple
Type of Service (TOS) 1 - Medical Care
Berenson-Eggers TOS (BETOS) P7B - Oncology - other
MUE 2
CCS Clinical Classification 237 - Ancillary Services
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
GA Waiver of liability statement issued as required by payer policy, individual case
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
25 Significant, separately identifiable evaluation and management service by the same physician or other qualified health care professional on the same day of the procedure or other service: it may be necessary to indicate that on the day a procedure or service identified by a cpt code was performed, the patient's condition required a significant, separately identifiable e/m service above and beyond the other service provided or beyond the usual preoperative and postoperative care associated with the procedure that was performed. a significant, separately identifiable e/m service is defined or substantiated by documentation that satisfies the relevant criteria for the respective e/m service to be reported (see evaluation and management services guidelines for instructions on determining level of e/m service). the e/m service may be prompted by the symptom or condition for which the procedure and/or service was provided. as such, different diagnoses are not required for reporting of the e/m services on the same date. this circumstance may be reported by adding modifier 25 to the appropriate level of e/m service. note: this modifier is not used to report an e/m service that resulted in a decision to perform surgery. see modifier 57 for significant, separately identifiable non-e/m services, see modifier 59.
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
JZ Zero drug amount discarded/not administered to any patient
KD Drug or biological infused through dme
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
Q5 Service furnished under a reciprocal billing arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
RT Right side (used to identify procedures performed on the right side of the body)
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
Date
Action
Notes
2011-01-01 Changed Short description changed.
2006-01-01 Added First appearance in code book in 2006.
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