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Official Description

Punch biopsy of skin (including simple closure, when performed); each separate/additional lesion (List separately in addition to code for primary procedure)

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

A punch biopsy is a medical procedure used to obtain a cylindrical sample of skin tissue for diagnostic purposes. This technique is particularly useful for evaluating various skin lesions, which may include pigmented nevi (moles), superficial inflammatory dermatoses (skin conditions characterized by inflammation), papulosquamous disorders (conditions that cause raised, scaly patches), granulomatous diseases (inflammatory conditions that result in the formation of granulomas), bullous disorders (conditions that cause blisters), connective tissue disorders, and benign tumors that appear non-cancerous. During the procedure, the skin is first anesthetized to minimize discomfort. A punch tool, which is a circular instrument of varying sizes, is selected based on the lesion's dimensions. The skin is then stretched perpendicular to the natural tension lines to facilitate a clean cut. The punch tool is applied to the skin and rotated to penetrate through the epidermis and into the reticular dermis and subcutaneous fat, capturing a full-thickness sample. Once the punch tool is removed, the edge of the specimen is grasped with forceps, lifted, and excised at the base using scissors. To manage any bleeding that may occur, methods such as electrocautery, aluminum chloride, or Monsel’s solution can be employed. After the biopsy, the resulting defect may be closed using simple sutures, staples, gelfoam, or adhesive bandages, which may include basic techniques to approximate the edges of the wound for optimal healing. It is important to note that CPT® Code 11104 is used to report a single lesion removed by punch biopsy, including any simple closure performed, while CPT® Code 11105 is designated for each additional lesion biopsied during the same session.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The punch biopsy procedure is indicated for the evaluation of various skin lesions, which may include:

  • Pigmented Nevi - These are moles or birthmarks that may require sampling to rule out malignancy.
  • Superficial Inflammatory Dermatoses - Conditions characterized by inflammation of the skin, which may need histological examination for diagnosis.
  • Papulosquamous Disorders - Skin conditions that present with raised, scaly patches, often requiring biopsy for accurate diagnosis.
  • Granulomatous Disorders - Inflammatory conditions that lead to the formation of granulomas, necessitating tissue sampling for evaluation.
  • Bullous Disorders - Conditions that cause blister formation, where biopsy can help determine the underlying cause.
  • Connective Tissue Disorders - These disorders affect the skin and underlying tissues, and a biopsy may be needed for diagnosis.
  • Benign-Appearing Tumors - Tumors that appear non-cancerous but require histological confirmation.

2. Procedure

The punch biopsy procedure involves several key steps to ensure accurate tissue sampling:

  • Step 1: Anesthesia - The area of the skin where the lesion is located is first anesthetized to minimize discomfort during the procedure. This is typically done using a local anesthetic.
  • Step 2: Selection of Punch Tool - An appropriately sized punch tool is selected based on the dimensions of the lesion to ensure a proper sample is obtained.
  • Step 3: Skin Preparation - The skin is stretched perpendicular to the natural tension lines to facilitate a clean and effective biopsy.
  • Step 4: Punching the Lesion - The punch tool is applied to the skin and rotated to penetrate through the epidermis, reticular dermis, and into the subcutaneous fat, capturing a cylindrical sample of tissue.
  • Step 5: Specimen Removal - After the punch tool is removed, the peripheral edge of the specimen is grasped with forceps, lifted, and excised at the base using scissors to ensure complete removal of the tissue sample.
  • Step 6: Hemostasis - Any bleeding that occurs is controlled using methods such as electrocautery, aluminum chloride, or Monsel’s solution to promote hemostasis.
  • Step 7: Wound Closure - The resulting defect may be closed using simple sutures, staples, gelfoam, or adhesive bandages, with any necessary manipulation to approximate the edges of the wound for optimal healing.

3. Post-Procedure

After the punch biopsy procedure, patients can expect some degree of discomfort and swelling at the biopsy site. It is important to monitor the area for signs of infection, such as increased redness, warmth, or discharge. Patients are typically advised to keep the area clean and dry, and to follow any specific aftercare instructions provided by the healthcare professional. Recovery time may vary depending on the individual and the size of the biopsy, but most patients can resume normal activities shortly after the procedure. Follow-up appointments may be necessary to discuss the biopsy results and any further treatment options if required.

Short Descr PUNCH BX SKIN EA SEP/ADDL
Medium Descr PUNCH BIOPSY SKIN EA SEP/ADDITIONAL LESION
Long Descr Punch biopsy of skin (including simple closure, when performed); each separate/additional lesion (List separately in addition to code for primary procedure)
Status Code Active Code
Global Days ZZZ - Code Related to Another Service
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
ASC Payment Indicator Packaged service/item; no separate payment made.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) none
MUE 3

This is an add-on code that must be used in conjunction with one of these primary codes.

11104 MPFS Status: Active Code APC T ASC P3 Punch biopsy of skin (including simple closure, when performed); single lesion
11106 MPFS Status: Active Code APC T ASC P3 Incisional biopsy of skin (eg, wedge) (including simple closure, when performed); single lesion
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
GC This service has been performed in part by a resident under the direction of a teaching physician
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
LT Left side (used to identify procedures performed on the left side of the body)
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
GA Waiver of liability statement issued as required by payer policy, individual case
PO Excepted service provided at an off-campus, outpatient, provider-based department of a hospital
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
RT Right side (used to identify procedures performed on the right side of the body)
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
SA Nurse practitioner rendering service in collaboration with a physician
25 Significant, separately identifiable evaluation and management service by the same physician or other qualified health care professional on the same day of the procedure or other service: it may be necessary to indicate that on the day a procedure or service identified by a cpt code was performed, the patient's condition required a significant, separately identifiable e/m service above and beyond the other service provided or beyond the usual preoperative and postoperative care associated with the procedure that was performed. a significant, separately identifiable e/m service is defined or substantiated by documentation that satisfies the relevant criteria for the respective e/m service to be reported (see evaluation and management services guidelines for instructions on determining level of e/m service). the e/m service may be prompted by the symptom or condition for which the procedure and/or service was provided. as such, different diagnoses are not required for reporting of the e/m services on the same date. this circumstance may be reported by adding modifier 25 to the appropriate level of e/m service. note: this modifier is not used to report an e/m service that resulted in a decision to perform surgery. see modifier 57 for significant, separately identifiable non-e/m services, see modifier 59.
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
80 Assistant surgeon: surgical assistant services may be identified by adding modifier 80 to the usual procedure number(s).
AG Primary physician
AM Physician, team member service
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
CR Catastrophe/disaster related
E2 Lower left, eyelid
E3 Upper right, eyelid
E4 Lower right, eyelid
F1 Left hand, second digit
FS Split (or shared) evaluation and management visit
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
GZ Item or service expected to be denied as not reasonable and necessary
PD Diagnostic or related non diagnostic item or service provided in a wholly owned or operated entity to a patient who is admitted as an inpatient within 3 days
PN Non-excepted service provided at an off-campus, outpatient, provider-based department of a hospital
Q5 Service furnished under a reciprocal billing arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
Q9 One class b and two class c findings
SG Ambulatory surgical center (asc) facility service
T2 Left foot, third digit
T4 Left foot, fifth digit
T5 Right foot, great toe
T6 Right foot, second digit
T7 Right foot, third digit
T8 Right foot, fourth digit
T9 Right foot, fifth digit
TA Left foot, great toe
TC Technical component; under certain circumstances, a charge may be made for the technical component alone; under those circumstances the technical component charge is identified by adding modifier 'tc' to the usual procedure number; technical component charges are institutional charges and not billed separately by physicians; however, portable x-ray suppliers only bill for technical component and should utilize modifier tc; the charge data from portable x-ray suppliers will then be used to build customary and prevailing profiles
U7 Medicaid level of care 7, as defined by each state
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
Date
Action
Notes
2019-01-01 Added Added
Code
Description
Code
Description
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