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Official Description

Application of skin substitute graft to trunk, arms, legs, total wound surface area up to 100 sq cm; first 25 sq cm or less wound surface area

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 15271 refers to the application of a skin substitute graft specifically designed for use on the trunk, arms, or legs, covering a total wound surface area of up to 100 square centimeters. This procedure is particularly relevant for treating open wounds that may be challenging to heal, such as burns, skin donor sites, diabetic ulcers, venous ulcers, and other chronic wounds affecting the skin and underlying soft tissues. The skin substitutes utilized in this procedure can be composed of acellular bioengineered constructs or allogeneic cells, which are derived from human donors. Examples of these skin substitutes include acellular dermal allografts, tissue cultured allogeneic skin substitutes, tissue cultured allogeneic dermal substitutes, and acellular xenografts. Each type of skin substitute has unique properties and methods of application, which are critical for promoting effective healing and recovery of the wound. The use of these advanced materials aims to enhance the healing process by providing a scaffold for tissue regeneration and reducing the risk of infection, ultimately leading to improved patient outcomes.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The application of skin substitute grafts, as described by CPT® Code 15271, is indicated for various conditions that result in open wounds. These include:

  • Burns - Severe skin damage caused by thermal, chemical, or electrical sources that require advanced treatment for healing.
  • Skin donor sites - Areas from which skin has been harvested for grafting purposes, often leading to open wounds that need coverage.
  • Diabetic ulcers - Chronic wounds that occur in patients with diabetes, often due to poor circulation and neuropathy.
  • Venous ulcers - Open sores that result from improper functioning of venous valves, leading to chronic skin breakdown.
  • Other hard-to-heal, chronic open wounds - Various conditions that result in non-healing wounds, necessitating the use of skin substitutes for effective treatment.

2. Procedure

The procedure for applying a skin substitute graft involves several detailed steps, which may vary depending on the type of skin substitute used. The following outlines the procedural steps:

  • Preparation of the wound bed - The wound area is first cleaned and prepared to ensure optimal conditions for graft application. This may involve debridement to remove any necrotic tissue and to create a healthy base for the skin substitute.
  • Selection and preparation of the skin substitute - Depending on the type of skin substitute being used, specific preparation steps are followed. For an acellular dermal allograft, the graft sheets are removed from their packaging, rehydrated in an isotonic sodium chloride solution, and trimmed to fit the dimensions of the wound. For tissue cultured allogeneic skin substitutes, fenestration is performed by creating a series of holes in the substitute to facilitate fluid drainage.
  • Application of the skin substitute - The prepared skin substitute is then applied to the wound bed. For acellular dermal allografts, the sheets are placed in a single or multiple layers and secured with absorbable sutures. Tissue cultured allogeneic skin substitutes are applied after fenestration, while tissue cultured allogeneic dermal substitutes are secured with sutures or staples. In the case of acellular xenografts, the implant sheet is cut to size and applied similarly.
  • Trimming excess material - Any excess skin substitute at the periphery of the wound is trimmed to ensure a proper fit and adherence to the wound bed.
  • Dressing application - After the skin substitute is secured, a layered dressing is applied. This includes a nonadherent layer to protect the graft, a bulky layer of gauze for absorption, a compression layer to minimize swelling, and an anti-shear layer to prevent friction and movement.

3. Post-Procedure

Post-procedure care following the application of a skin substitute graft is crucial for ensuring proper healing and minimizing complications. Patients are typically advised to keep the dressing intact and dry for a specified period, as determined by the healthcare provider. Regular monitoring of the wound site is essential to assess for signs of infection or graft failure. Follow-up appointments may be scheduled to evaluate the healing process and to make any necessary adjustments to the treatment plan. Patients should also be educated on signs of complications, such as increased redness, swelling, or discharge, and instructed to report these to their healthcare provider promptly.

Short Descr SKIN SUB GRAFT TRNK/ARM/LEG
Medium Descr APP SKN SUB GRFT T/A/L AREA/100SQ CM /<1ST 25
Long Descr Application of skin substitute graft to trunk, arms, legs, total wound surface area up to 100 sq cm; first 25 sq cm or less wound surface area
Status Code Active Code
Global Days 000 - Endoscopic or Minor Procedure
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Multiple Reduction Applies
ASC Payment Indicator Non office-based surgical procedure added in CY 2008 or later; payment based on OPPS relative payment weight.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P5A - Ambulatory procedures - skin
MUE 1
CCS Clinical Classification 172 - Skin graft

This is a primary code that can be used with these additional add-on codes.

15272 Addon Code MPFS Status: Active Code APC N ASC N1 Application of skin substitute graft to trunk, arms, legs, total wound surface area up to 100 sq cm; each additional 25 sq cm wound surface area, or part thereof (List separately in addition to code for primary procedure)
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
GW Service not related to the hospice patient's terminal condition
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
LT Left side (used to identify procedures performed on the left side of the body)
RT Right side (used to identify procedures performed on the right side of the body)
KX Requirements specified in the medical policy have been met
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
JC Skin substitute used as a graft
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
GF Non-physician (e.g. nurse practitioner (np), certified registered nurse anesthetist (crna), certified registered nurse (crn), clinical nurse specialist (cns), physician assistant (pa)) services in a critical access hospital
JZ Zero drug amount discarded/not administered to any patient
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
CR Catastrophe/disaster related
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
X2 Continuous/focused services: for reporting services by clinicians whose expertise is needed for the ongoing management of a chronic disease or a condition that needs to be managed and followed with no planned endpoint to the relationship; reporting clinician service examples include but are not limited to: a rheumatologist taking care of the patient's rheumatoid arthritis longitudinally but not providing general primary care services
GC This service has been performed in part by a resident under the direction of a teaching physician
T6 Right foot, second digit
22 Increased procedural services: when the work required to provide a service is substantially greater than typically required, it may be identified by adding modifier 22 to the usual procedure code. documentation must support the substantial additional work and the reason for the additional work (ie, increased intensity, time, technical difficulty of procedure, severity of patient's condition, physical and mental effort required). note: this modifier should not be appended to an e/m service.
25 Significant, separately identifiable evaluation and management service by the same physician or other qualified health care professional on the same day of the procedure or other service: it may be necessary to indicate that on the day a procedure or service identified by a cpt code was performed, the patient's condition required a significant, separately identifiable e/m service above and beyond the other service provided or beyond the usual preoperative and postoperative care associated with the procedure that was performed. a significant, separately identifiable e/m service is defined or substantiated by documentation that satisfies the relevant criteria for the respective e/m service to be reported (see evaluation and management services guidelines for instructions on determining level of e/m service). the e/m service may be prompted by the symptom or condition for which the procedure and/or service was provided. as such, different diagnoses are not required for reporting of the e/m services on the same date. this circumstance may be reported by adding modifier 25 to the appropriate level of e/m service. note: this modifier is not used to report an e/m service that resulted in a decision to perform surgery. see modifier 57 for significant, separately identifiable non-e/m services, see modifier 59.
50 Bilateral procedure: unless otherwise identified in the listings, bilateral procedures that are performed at the same session, should be identified by adding modifier 50 to the appropriate 5 digit code. note: this modifier should not be appended to designated "add-on" codes (see appendix d).
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
56 Preoperative management only: when 1 physician or other qualified health care professional performed the preoperative care and evaluation and another performed the surgical procedure, the preoperative component may be identified by adding modifier 56 to the usual procedure number.
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
80 Assistant surgeon: surgical assistant services may be identified by adding modifier 80 to the usual procedure number(s).
82 Assistant surgeon (when qualified resident surgeon not available): the unavailability of a qualified resident surgeon is a prerequisite for use of modifier 82 appended to the usual procedure code number(s).
95 Synchronous telemedicine service rendered via a real-time interactive audio and video telecommunications system: synchronous telemedicine service is defined as a real-time interaction between a physician or other qualified health care professional and a patient who is located at a distant site from the physician or other qualified health care professional. the totality of the communication of information exchanged between the physician or other qualified health care professional and the patient during the course of the synchronous telemedicine service must be of an amount and nature that would be sufficient to meet the key components and/or requirements of the same service when rendered via a face-to-face interaction. modifier 95 may only be appended to the services listed in appendix p. appendix p is the list of cpt codes for services that are typically performed face-to-face, but may be rendered via a real-time (synchronous) interactive audio and video telecommunications system.
A1 Dressing for one wound
A2 Dressing for two wounds
AG Primary physician
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
F3 Left hand, fourth digit
F7 Right hand, third digit
F8 Right hand, fourth digit
GA Waiver of liability statement issued as required by payer policy, individual case
GB Claim being re-submitted for payment because it is no longer covered under a global payment demonstration
GE This service has been performed by a resident without the presence of a teaching physician under the primary care exception
GQ Via asynchronous telecommunications system
GX Notice of liability issued, voluntary under payer policy
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
GZ Item or service expected to be denied as not reasonable and necessary
JW Drug amount discarded/not administered to any patient
LC Left circumflex coronary artery
PD Diagnostic or related non diagnostic item or service provided in a wholly owned or operated entity to a patient who is admitted as an inpatient within 3 days
PO Excepted service provided at an off-campus, outpatient, provider-based department of a hospital
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
Q5 Service furnished under a reciprocal billing arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
Q7 One class a finding
Q8 Two class b findings
SA Nurse practitioner rendering service in collaboration with a physician
SG Ambulatory surgical center (asc) facility service
T1 Left foot, second digit
T4 Left foot, fifth digit
T5 Right foot, great toe
T7 Right foot, third digit
TA Left foot, great toe
Date
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2013-01-01 Changed Medium Descriptor changed.
2012-01-01 Added Added
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