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Official Description

Application of skin substitute graft to trunk, arms, legs, total wound surface area up to 100 sq cm; each additional 25 sq cm wound surface area, or part thereof (List separately in addition to code for primary procedure)

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 15272 refers to the application of a skin substitute graft specifically designed for treating wounds located on the trunk, arms, or legs. This procedure is applicable for total wound surface areas measuring up to 100 square centimeters. Skin substitutes are advanced medical products that can be composed of acellular bioengineered constructs or allogeneic cells, and they are utilized to facilitate the healing process of various types of open wounds. These may include burns, skin donor sites, diabetic ulcers, venous ulcers, and other chronic wounds that are difficult to heal. The skin substitutes can take various forms, such as acellular dermal allografts, tissue cultured allogeneic skin substitutes, tissue cultured allogeneic dermal substitutes, and acellular xenografts. Each type of skin substitute has unique properties and methods of application, which are critical for effective wound management. The procedure involves careful preparation of the wound bed and precise application of the skin substitute to ensure optimal healing and integration with the surrounding tissue.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The application of skin substitute grafts, including CPT® Code 15272, is indicated for the treatment of various types of open wounds. These indications include:

  • Burns - Severe skin damage caused by thermal, chemical, or electrical sources that require advanced wound care.
  • Skin donor sites - Areas from which skin has been harvested for grafting purposes, necessitating closure and healing support.
  • Diabetic ulcers - Chronic wounds that occur due to complications from diabetes, often requiring specialized treatment to promote healing.
  • Venous ulcers - Wounds resulting from poor venous circulation, typically located on the lower extremities, that are difficult to heal without intervention.
  • Chronic open wounds - Other hard-to-heal wounds that do not respond to standard treatment methods and require advanced therapeutic options.

2. Procedure

The procedure for applying a skin substitute graft involves several critical steps, which may vary depending on the type of skin substitute used. The following outlines the procedural steps:

  • Preparation of the wound bed - The wound area is thoroughly cleaned and debrided to remove any necrotic tissue, ensuring a healthy base for the skin substitute application.
  • Selection of the skin substitute - The appropriate type of skin substitute is chosen based on the specific characteristics of the wound and the desired healing properties.
  • Application of acellular dermal allograft - If this type is selected, the dermal allograft sheets are removed from their packaging, rehydrated in an isotonic sodium chloride solution, and trimmed to fit the wound dimensions. The sheets are then applied over the prepared wound bed, either in single or multiple layers, and secured using absorbable sutures. Any excess material at the wound's periphery is trimmed away.
  • Application of tissue cultured allogeneic skin substitute - This substitute is fenestrated, meaning a series of holes or openings are created in the material. The fenestrated skin substitute is then placed on the prepared wound bed and secured with sutures to ensure proper adherence.
  • Application of tissue cultured allogeneic dermal substitute - This substitute is applied directly to the wound bed and secured with either sutures or staples, depending on the clinical scenario.
  • Application of acellular xenograft - For this type, the implant sheet is cut to the appropriate size and shape of the wound, applied to the prepared wound bed, and secured with sutures.
  • Layered dressing application - After the skin substitute is applied, a layered dressing is placed over the graft. This dressing typically includes a nonadherent layer to protect the graft, a bulky layer of gauze for absorption, a compression layer to support the wound, and an anti-shear layer to minimize friction and movement.

3. Post-Procedure

Post-procedure care following the application of a skin substitute graft is essential for promoting healing and preventing complications. Patients are typically advised to keep the area clean and dry, and to monitor for any signs of infection, such as increased redness, swelling, or discharge. Follow-up appointments are necessary to assess the healing progress and to change dressings as needed. The healthcare provider may also provide specific instructions regarding activity restrictions to avoid stress on the grafted area. The expected recovery time can vary based on the type of skin substitute used and the individual patient's healing response.

Short Descr SKIN SUB GRAFT T/A/L ADD-ON
Medium Descr APP SKN SUB GRFT T/A/L AREA/100SQ CM EA ADL 25SC
Long Descr Application of skin substitute graft to trunk, arms, legs, total wound surface area up to 100 sq cm; each additional 25 sq cm wound surface area, or part thereof (List separately in addition to code for primary procedure)
Status Code Active Code
Global Days ZZZ - Code Related to Another Service
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
ASC Payment Indicator Packaged service/item; no separate payment made.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P5A - Ambulatory procedures - skin
MUE 3
CCS Clinical Classification 172 - Skin graft

This is an add-on code that must be used in conjunction with one of these primary codes.

15271 MPFS Status: Active Code APC T ASC G2 Application of skin substitute graft to trunk, arms, legs, total wound surface area up to 100 sq cm; first 25 sq cm or less wound surface area
GW Service not related to the hospice patient's terminal condition
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
KX Requirements specified in the medical policy have been met
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
LT Left side (used to identify procedures performed on the left side of the body)
RT Right side (used to identify procedures performed on the right side of the body)
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
GC This service has been performed in part by a resident under the direction of a teaching physician
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
82 Assistant surgeon (when qualified resident surgeon not available): the unavailability of a qualified resident surgeon is a prerequisite for use of modifier 82 appended to the usual procedure code number(s).
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
80 Assistant surgeon: surgical assistant services may be identified by adding modifier 80 to the usual procedure number(s).
99 Multiple modifiers: under certain circumstances 2 or more modifiers may be necessary to completely delineate a service. in such situations modifier 99 should be added to the basic procedure, and other applicable modifiers may be listed as part of the description of the service.
AG Primary physician
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
CR Catastrophe/disaster related
GA Waiver of liability statement issued as required by payer policy, individual case
GE This service has been performed by a resident without the presence of a teaching physician under the primary care exception
GF Non-physician (e.g. nurse practitioner (np), certified registered nurse anesthetist (crna), certified registered nurse (crn), clinical nurse specialist (cns), physician assistant (pa)) services in a critical access hospital
GX Notice of liability issued, voluntary under payer policy
GZ Item or service expected to be denied as not reasonable and necessary
JC Skin substitute used as a graft
JZ Zero drug amount discarded/not administered to any patient
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
SA Nurse practitioner rendering service in collaboration with a physician
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
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Action
Notes
2013-01-01 Changed Medium Descriptor changed.
2012-01-01 Added Added Code for 2012
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