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Official Description

Application of skin substitute graft to trunk, arms, legs, total wound surface area greater than or equal to 100 sq cm; first 100 sq cm wound surface area, or 1% of body area of infants and children

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 15273 refers to the application of a skin substitute graft specifically designed for treating extensive wounds on the trunk, arms, or legs. This procedure is indicated for wounds with a total surface area that is greater than or equal to 100 square centimeters. The skin substitute utilized in this procedure is composed of acellular bioengineered constructs and/or allogeneic cells, which are essential for promoting the healing of various types of open wounds. These may include burns, skin donor sites, diabetic ulcers, venous ulcers, and other chronic wounds that are difficult to heal. The skin substitutes can take various forms, such as acellular dermal allografts, tissue cultured allogeneic skin substitutes, tissue cultured allogeneic dermal substitutes, and acellular xenografts. Each type of skin substitute has unique properties and methods of application, which are critical for effective wound management. The procedure is particularly relevant for infants and children, where the wound surface area treated may be calculated as 1% of their total body surface area (TBSA). This code is specifically used for the first 100 square centimeters of wound surface area in adults or the equivalent percentage in pediatric patients, ensuring that the treatment is appropriately documented and billed for the extensive care provided.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The application of skin substitute grafts using CPT® Code 15273 is indicated for the treatment of extensive open wounds on the trunk, arms, or legs. The specific indications include:

  • Burns: Severe skin damage resulting from thermal injury that requires advanced wound care.
  • Skin donor sites: Areas where skin has been harvested for grafting, which may require coverage to promote healing.
  • Diabetic ulcers: Chronic wounds that occur due to diabetes-related complications, often requiring specialized treatment.
  • Venous ulcers: Wounds resulting from poor venous circulation, typically found on the lower extremities.
  • Chronic open wounds: Other hard-to-heal wounds that do not respond to standard treatment methods.

2. Procedure

The procedure for applying a skin substitute graft involves several critical steps, which may vary depending on the type of skin substitute used. The following procedural steps are outlined:

  • Preparation of the wound bed: The wound area is first cleaned and prepared to ensure optimal conditions for graft application. This may involve debridement to remove any necrotic tissue and to create a healthy base for the graft.
  • Selection of the skin substitute: The appropriate type of skin substitute is chosen based on the specific characteristics of the wound and the patient's needs. Options include acellular dermal allografts, tissue cultured allogeneic skin substitutes, tissue cultured allogeneic dermal substitutes, and acellular xenografts.
  • Application of acellular dermal allograft: If this type is selected, the dermal allograft sheets are removed from their packaging, rehydrated in an isotonic sodium chloride solution, and trimmed to fit the wound dimensions. The sheets are then applied over the prepared wound bed, either in a single layer or multiple layers, and secured using absorbable sutures. Any excess material at the wound's periphery is trimmed away.
  • Application of tissue cultured allogeneic skin substitute: This substitute is fenestrated, meaning a series of holes or openings are created in the material. The fenestrated skin substitute is then placed on the prepared wound bed and secured with sutures to ensure proper adherence.
  • Application of tissue cultured allogeneic dermal substitute: This substitute is applied directly to the wound bed and secured with either sutures or staples, depending on the clinical scenario.
  • Application of acellular xenograft: For this type, the implant sheet is cut to the appropriate size and shape of the wound, applied to the prepared wound bed, and secured with sutures.
  • Dressing application: After the skin substitute is applied, a layered dressing is placed over the graft. This dressing typically includes a nonadherent layer to protect the graft, a bulky layer of gauze for absorption, a compression layer to minimize swelling, and an anti-shear layer to reduce friction and movement.

3. Post-Procedure

Post-procedure care following the application of a skin substitute graft is crucial for ensuring proper healing and minimizing complications. Patients are typically monitored for signs of infection, graft adherence, and overall wound healing progress. It is essential to keep the dressing intact and dry, changing it as directed by the healthcare provider. Patients may be advised on activity restrictions to avoid stress on the graft site. Follow-up appointments are necessary to assess the healing process and to determine if additional treatments or interventions are required. The expected recovery time may vary based on the individual patient's condition and the extent of the wound treated.

Short Descr SKIN SUB GRFT T/ARM/LG CHILD
Medium Descr APP SKN SUBGRFT T/A/L AREA/100SQ CM 1ST 100SQ CM
Long Descr Application of skin substitute graft to trunk, arms, legs, total wound surface area greater than or equal to 100 sq cm; first 100 sq cm wound surface area, or 1% of body area of infants and children
Status Code Active Code
Global Days 000 - Endoscopic or Minor Procedure
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Multiple Reduction Applies
ASC Payment Indicator Non office-based surgical procedure added in CY 2008 or later; payment based on OPPS relative payment weight.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P5A - Ambulatory procedures - skin
MUE 1
CCS Clinical Classification 172 - Skin graft

This is a primary code that can be used with these additional add-on codes.

15274 Addon Code MPFS Status: Active Code APC N ASC N1 Application of skin substitute graft to trunk, arms, legs, total wound surface area greater than or equal to 100 sq cm; each additional 100 sq cm wound surface area, or part thereof, or each additional 1% of body area of infants and children, or part thereof (List separately in addition to code for primary procedure)
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
GW Service not related to the hospice patient's terminal condition
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
LT Left side (used to identify procedures performed on the left side of the body)
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
GC This service has been performed in part by a resident under the direction of a teaching physician
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
RT Right side (used to identify procedures performed on the right side of the body)
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
KX Requirements specified in the medical policy have been met
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
22 Increased procedural services: when the work required to provide a service is substantially greater than typically required, it may be identified by adding modifier 22 to the usual procedure code. documentation must support the substantial additional work and the reason for the additional work (ie, increased intensity, time, technical difficulty of procedure, severity of patient's condition, physical and mental effort required). note: this modifier should not be appended to an e/m service.
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
80 Assistant surgeon: surgical assistant services may be identified by adding modifier 80 to the usual procedure number(s).
82 Assistant surgeon (when qualified resident surgeon not available): the unavailability of a qualified resident surgeon is a prerequisite for use of modifier 82 appended to the usual procedure code number(s).
AG Primary physician
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
CR Catastrophe/disaster related
F1 Left hand, second digit
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
GZ Item or service expected to be denied as not reasonable and necessary
JC Skin substitute used as a graft
JW Drug amount discarded/not administered to any patient
JZ Zero drug amount discarded/not administered to any patient
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
SA Nurse practitioner rendering service in collaboration with a physician
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
XP Separate practitioner, a service that is distinct because it was performed by a different practitioner
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
Date
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Notes
2013-01-01 Changed Medium Descriptor changed.
2012-01-01 Added Added
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