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Official Description

Application of skin substitute graft to trunk, arms, legs, total wound surface area greater than or equal to 100 sq cm; each additional 100 sq cm wound surface area, or part thereof, or each additional 1% of body area of infants and children, or part thereof (List separately in addition to code for primary procedure)

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 15274 refers to the application of a skin substitute graft specifically for larger wounds located on the trunk, arms, or legs, where the total wound surface area is greater than or equal to 100 square centimeters. This procedure is particularly relevant for treating various types of chronic, hard-to-heal wounds, including those resulting from burns, skin donor sites, diabetic ulcers, and venous ulcers. Skin substitutes are advanced medical products that can be composed of acellular bioengineered constructs or allogeneic cells, designed to promote healing by providing a temporary biological covering over the wound. Examples of these substitutes include acellular dermal allografts, tissue cultured allogeneic skin substitutes, and acellular xenografts, each with unique properties and applications. The use of these substitutes is critical in managing extensive wounds, as they facilitate the healing process and help restore the integrity of the skin and underlying soft tissues. The procedure is billed separately for each additional 100 square centimeters of wound surface area beyond the initial 100 square centimeters, or for each additional 1% of total body surface area (TBSA) in infants and children, ensuring that the complexity and extent of the treatment are accurately captured in the coding process.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The application of skin substitute grafts, as described by CPT® Code 15274, is indicated for the treatment of extensive wounds on the trunk, arms, or legs. These indications include:

  • Burns: Severe burns that result in significant skin loss and require advanced wound care to promote healing.
  • Skin Donor Sites: Areas where skin has been harvested for grafting, which may need coverage to facilitate healing.
  • Diabetic Ulcers: Chronic wounds that occur in diabetic patients, often due to poor circulation and neuropathy.
  • Venous Ulcers: Wounds that result from improper functioning of venous valves, leading to chronic skin breakdown.
  • Other Hard-to-Heal Wounds: Any chronic, open wounds of the skin and underlying soft tissues that do not respond to standard treatments.

2. Procedure

The procedure for applying a skin substitute graft involves several detailed steps, which may vary depending on the type of skin substitute used. The following procedural steps outline the general approach:

  • Step 1: Preparation of the Wound Bed - The wound is first cleaned and prepared to ensure that it is free of debris and infection. This may involve debridement to remove any non-viable tissue.
  • Step 2: Selection of Skin Substitute - The appropriate type of skin substitute is selected based on the specific needs of the wound and the patient's condition. Options include acellular dermal allografts, tissue cultured allogeneic skin substitutes, and acellular xenografts.
  • Step 3: Application of Acellular Dermal Allograft - If an acellular dermal allograft is chosen, the graft sheets are removed from their packaging, rehydrated in an isotonic sodium chloride solution, and trimmed to fit the wound. The sheets are then applied over the wound bed in one or multiple layers and secured with absorbable sutures, with any excess trimmed away.
  • Step 4: Application of Tissue Cultured Allogeneic Skin Substitute - For this type of substitute, the graft is fenestrated, meaning a series of holes are made to allow for drainage and integration. The fenestrated graft is then placed on the wound bed and secured with sutures.
  • Step 5: Application of Tissue Cultured Allogeneic Dermal Substitute - This substitute is applied directly to the wound bed and secured using sutures or staples, ensuring proper adherence to the underlying tissue.
  • Step 6: Application of Acellular Xenograft - If an acellular xenograft is used, the sheet is cut to the appropriate size and shape of the wound, applied to the prepared wound bed, and secured with sutures.
  • Step 7: Dressing Application - After the skin substitute is applied, a layered dressing is placed over the graft. This dressing typically includes a nonadherent layer, a bulky layer of gauze, a compression layer, and an anti-shear layer to protect the graft and promote healing.

3. Post-Procedure

Post-procedure care following the application of a skin substitute graft is crucial for ensuring optimal healing and minimizing complications. Patients are typically advised to keep the area clean and dry, and to monitor for any signs of infection, such as increased redness, swelling, or discharge. Follow-up appointments are essential to assess the healing process and to determine if additional treatments or interventions are necessary. The layered dressing applied during the procedure may need to be changed periodically, as directed by the healthcare provider, to maintain a conducive healing environment. Patients should also be educated on the importance of avoiding trauma to the grafted area and adhering to any prescribed activity restrictions during the recovery period.

Short Descr SKN SUB GRFT T/A/L CHILD ADD
Medium Descr APP SKN SUB GRFT T/A/L AREA>=100SCM ADL 100SQCM
Long Descr Application of skin substitute graft to trunk, arms, legs, total wound surface area greater than or equal to 100 sq cm; each additional 100 sq cm wound surface area, or part thereof, or each additional 1% of body area of infants and children, or part thereof (List separately in addition to code for primary procedure)
Status Code Active Code
Global Days ZZZ - Code Related to Another Service
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
ASC Payment Indicator Packaged service/item; no separate payment made.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P5A - Ambulatory procedures - skin
MUE 60
CCS Clinical Classification 172 - Skin graft

This is an add-on code that must be used in conjunction with one of these primary codes.

15273 MPFS Status: Active Code APC T ASC G2 Application of skin substitute graft to trunk, arms, legs, total wound surface area greater than or equal to 100 sq cm; first 100 sq cm wound surface area, or 1% of body area of infants and children
GC This service has been performed in part by a resident under the direction of a teaching physician
GW Service not related to the hospice patient's terminal condition
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
LT Left side (used to identify procedures performed on the left side of the body)
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
CR Catastrophe/disaster related
KX Requirements specified in the medical policy have been met
RT Right side (used to identify procedures performed on the right side of the body)
JZ Zero drug amount discarded/not administered to any patient
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
XP Separate practitioner, a service that is distinct because it was performed by a different practitioner
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
22 Increased procedural services: when the work required to provide a service is substantially greater than typically required, it may be identified by adding modifier 22 to the usual procedure code. documentation must support the substantial additional work and the reason for the additional work (ie, increased intensity, time, technical difficulty of procedure, severity of patient's condition, physical and mental effort required). note: this modifier should not be appended to an e/m service.
82 Assistant surgeon (when qualified resident surgeon not available): the unavailability of a qualified resident surgeon is a prerequisite for use of modifier 82 appended to the usual procedure code number(s).
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
73 Discontinued out-patient hospital/ambulatory surgery center (asc) procedure prior to the administration of anesthesia: due to extenuating circumstances or those that threaten the well being of the patient, the physician may cancel a surgical or diagnostic procedure subsequent to the patient's surgical preparation (including sedation when provided, and being taken to the room where the procedure is to be performed), but prior to the administration of anesthesia (local, regional block(s) or general). under these circumstances, the intended service that is prepared for but cancelled can be reported by its usual procedure number and the addition of modifier 73. note: the elective cancellation of a service prior to the administration of anesthesia and/or surgical preparation of the patient should not be reported. for physician reporting of a discontinued procedure, see modifier 53.
80 Assistant surgeon: surgical assistant services may be identified by adding modifier 80 to the usual procedure number(s).
A3 Dressing for three wounds
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
JC Skin substitute used as a graft
SA Nurse practitioner rendering service in collaboration with a physician
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
Date
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2013-01-01 Changed Medium Descriptor changed.
2012-01-01 Added Added
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