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Official Description

Application of skin substitute graft to face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits, total wound surface area greater than or equal to 100 sq cm; first 100 sq cm wound surface area, or 1% of body area of infants and children

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Common Language Description

The CPT® Code 15277 refers to the application of a skin substitute graft specifically designed for use on various sensitive areas of the body, including the face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and multiple digits. This procedure is indicated for wounds with a total surface area that is greater than or equal to 100 square centimeters. The skin substitute utilized in this procedure is composed of acellular bioengineered constructs and/or allogeneic cells, which are essential for promoting the healing of open wounds. Skin substitutes are particularly beneficial for treating challenging conditions such as burns, skin donor sites, diabetic or venous ulcers, and other chronic wounds that are difficult to heal. Examples of skin substitutes include acellular dermal allografts, which are chemically treated skin grafts derived from cadaver donors, and tissue cultured allogeneic skin substitutes, which consist of two layers: an upper layer of cultured human keratinocytes and a lower layer of human fibroblasts. Additionally, tissue cultured allogeneic dermal substitutes are made from human fibroblast cells seeded onto a bioabsorbable mesh scaffold, allowing for the creation of a metabolically active dermal substitute. Acellular xenografts, derived from other species such as pigs or cows, are also utilized, with the cellular components removed to create an acellular product that consists of collagen and elastin fibers. The procedure for applying these skin substitutes varies depending on the type used, but generally involves preparing the wound bed, applying the skin substitute, and securing it in place with sutures or staples. Following the application, a layered dressing is typically placed over the graft to protect the area and promote healing. This code is specifically used for the first 100 square centimeters of wound surface area in adults or for 1% of the total body surface area (TBSA) in infants and children, ensuring that the treatment is appropriately documented and billed for the extensive care provided.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The application of a skin substitute graft using CPT® Code 15277 is indicated for the treatment of various types of wounds that require advanced healing techniques. The specific indications include:

  • Burns - Severe skin damage resulting from thermal, chemical, or electrical sources that necessitate skin grafting for proper healing.
  • Skin Donor Sites - Areas where skin has been harvested for grafting purposes, which may require a skin substitute to promote healing.
  • Diabetic Ulcers - Chronic wounds that occur due to diabetes, often on the feet, which can be difficult to heal without advanced treatment.
  • Venous Ulcers - Wounds that result from poor blood circulation, typically found on the lower extremities, requiring specialized care.
  • Chronic Open Wounds - Any hard-to-heal wounds of the skin and underlying soft tissues that do not respond to standard treatment methods.

2. Procedure

The procedure for applying a skin substitute graft as described by CPT® Code 15277 involves several critical steps, which may vary depending on the specific type of skin substitute used. The following procedural steps outline the general approach:

  • Preparation of the Wound Bed - The wound area is thoroughly cleaned and prepared to ensure optimal conditions for graft application. This may involve debridement of necrotic tissue and ensuring hemostasis.
  • Selection and Preparation of the Skin Substitute - Depending on the type of skin substitute being used, the graft is selected and prepared. For acellular dermal allografts, the sheets are removed from their packaging, rehydrated in an isotonic sodium chloride solution, and trimmed to fit the wound dimensions. Tissue cultured allogeneic skin substitutes are fenestrated to create openings that facilitate fluid drainage.
  • Application of the Skin Substitute - The prepared skin substitute is applied directly to the wound bed. For acellular dermal allografts, the sheets are placed in a single or multiple layers and secured with absorbable sutures. Tissue cultured allogeneic skin substitutes are also secured with sutures after being fenestrated. Acellular xenografts are cut to size and applied similarly, ensuring proper adherence to the wound.
  • Trimming Excess Graft Material - Any excess material at the periphery of the wound is trimmed to ensure a proper fit and to avoid complications.
  • Application of Dressings - After the skin substitute is secured, a layered dressing is applied. This typically includes a nonadherent layer to protect the graft, a bulky layer of gauze for absorption, a compression layer to minimize swelling, and an anti-shear layer to prevent friction.

3. Post-Procedure

Post-procedure care following the application of a skin substitute graft is crucial for ensuring optimal healing and minimizing complications. Patients are typically monitored for signs of infection, graft rejection, or other adverse reactions. The layered dressing applied over the graft should remain intact for a specified period, as directed by the healthcare provider. Patients may be advised on how to care for the graft site, including instructions on keeping the area clean and dry. Follow-up appointments are essential to assess the healing process and to determine if additional interventions are necessary. The expected recovery time may vary based on the individual’s health status and the extent of the wound treated.

Short Descr SKN SUB GRFT F/N/HF/G CHILD
Medium Descr SUB GRFT F/S/N/H/F/G/M/D >= 100SCM 1ST 100SQ CM
Long Descr Application of skin substitute graft to face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits, total wound surface area greater than or equal to 100 sq cm; first 100 sq cm wound surface area, or 1% of body area of infants and children
Status Code Active Code
Global Days 000 - Endoscopic or Minor Procedure
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 1 - Co-surgeons could be paid, though supporting documentation is required...
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Multiple Reduction Applies
ASC Payment Indicator Non office-based surgical procedure added in CY 2008 or later; payment based on OPPS relative payment weight.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P5A - Ambulatory procedures - skin
MUE 1
CCS Clinical Classification 172 - Skin graft

This is a primary code that can be used with these additional add-on codes.

15278 Addon Code MPFS Status: Active Code APC N ASC N1 Application of skin substitute graft to face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits, total wound surface area greater than or equal to 100 sq cm; each additional 100 sq cm wound surface area, or part thereof, or each additional 1% of body area of infants and children, or part thereof (List separately in addition to code for primary procedure)
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
62 Two surgeons: when 2 surgeons work together as primary surgeons performing distinct part(s) of a procedure, each surgeon should report his/her distinct operative work by adding modifier 62 to the procedure code and any associated add-on code(s) for that procedure as long as both surgeons continue to work together as primary surgeons. each surgeon should report the co-surgery once using the same procedure code. if additional procedure(s) (including add-on procedure(s) are performed during the same surgical session, separate code(s) may also be reported with modifier 62 added. note: if a co-surgeon acts as an assistant in the performance of additional procedure(s), other than those reported with the modifier 62, during the same surgical session, those services may be reported using separate procedure code(s) with modifier 80 or modifier 82 added, as appropriate.
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
80 Assistant surgeon: surgical assistant services may be identified by adding modifier 80 to the usual procedure number(s).
82 Assistant surgeon (when qualified resident surgeon not available): the unavailability of a qualified resident surgeon is a prerequisite for use of modifier 82 appended to the usual procedure code number(s).
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
CR Catastrophe/disaster related
F1 Left hand, second digit
F5 Right hand, thumb
F6 Right hand, second digit
GC This service has been performed in part by a resident under the direction of a teaching physician
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
GZ Item or service expected to be denied as not reasonable and necessary
JZ Zero drug amount discarded/not administered to any patient
KX Requirements specified in the medical policy have been met
LT Left side (used to identify procedures performed on the left side of the body)
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
RT Right side (used to identify procedures performed on the right side of the body)
T5 Right foot, great toe
XP Separate practitioner, a service that is distinct because it was performed by a different practitioner
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
Date
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2013-01-01 Changed Medium Descriptor changed.
2012-01-01 Added Added
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