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Official Description

Application of skin substitute graft to face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits, total wound surface area greater than or equal to 100 sq cm; each additional 100 sq cm wound surface area, or part thereof, or each additional 1% of body area of infants and children, or part thereof (List separately in addition to code for primary procedure)

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 15278 refers to the application of a skin substitute graft specifically designed for extensive wounds located on various anatomical sites, including the face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and multiple digits. This procedure is indicated when the total wound surface area is greater than or equal to 100 square centimeters. Skin substitutes are advanced medical products that can be composed of acellular bioengineered constructs or allogeneic cells, and they are utilized to facilitate the healing process of open wounds. These wounds may arise from various conditions such as burns, skin donor sites, diabetic ulcers, venous ulcers, or other chronic wounds that are difficult to heal. The skin substitutes used in this procedure can include a range of products, such as acellular dermal allografts, tissue cultured allogeneic skin substitutes, tissue cultured allogeneic dermal substitutes, and acellular xenografts. Acellular dermal allografts are derived from cadaver donors and have undergone chemical treatment to remove antigenic epidermal cellular components, making them suitable for transplantation. Tissue cultured allogeneic skin substitutes consist of two layers: an upper layer of human keratinocytes that form the epidermis and a lower layer of human fibroblasts cultured on a collagen matrix. Tissue cultured allogeneic dermal substitutes are created using fibroblast cells from newborn foreskin tissue, which are seeded onto a bioabsorbable mesh scaffold, allowing for the growth of living cells that secrete essential components for skin regeneration. Acellular xenografts, on the other hand, are sourced from other species, typically pigs or cows, and are processed to remove cellular material, resulting in a graft composed of acellular collagen and elastin fibers. The application of these skin substitutes involves specific procedural steps that vary depending on the type of graft used, ensuring that the wound is adequately covered and secured to promote optimal healing.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The application of skin substitute grafts, specifically CPT® Code 15278, is indicated for the treatment of extensive open wounds that meet the following criteria:

  • Extensive Wound Surface Area Total wound surface area greater than or equal to 100 square centimeters.
  • Anatomical Locations Wounds located on the face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits.
  • Chronic Wounds Wounds that are hard-to-heal, such as burns, skin donor sites, diabetic ulcers, or venous ulcers.

2. Procedure

The procedure for applying a skin substitute graft involves several detailed steps, which may vary depending on the specific type of skin substitute used. Below are the procedural steps associated with CPT® Code 15278:

  • Preparation of the Wound Bed The wound bed must be thoroughly prepared to ensure optimal adherence and healing. This may involve debridement of necrotic tissue and cleaning the area to create a suitable environment for the graft.
  • Selection of Skin Substitute The appropriate skin substitute is selected based on the characteristics of the wound and the specific needs of the patient. Options include acellular dermal allografts, tissue cultured allogeneic skin substitutes, tissue cultured allogeneic dermal substitutes, and acellular xenografts.
  • Application of Acellular Dermal Allograft If an acellular dermal allograft is chosen, the graft sheets are removed from their packaging, rehydrated in an isotonic sodium chloride solution, and trimmed to fit the wound dimensions. The sheets are then applied over the prepared wound bed, either in single or multiple layers, and secured using absorbable sutures. Any excess material at the wound's periphery is trimmed away.
  • Application of Tissue Cultured Allogeneic Skin Substitute For tissue cultured allogeneic skin substitutes, the graft is fenestrated by creating a series of holes or openings. This fenestrated graft is then placed on the prepared wound bed and secured with sutures to ensure proper adherence.
  • Application of Tissue Cultured Allogeneic Dermal Substitute The tissue cultured allogeneic dermal substitute is applied directly to the wound bed and secured using either sutures or staples, depending on the clinical scenario.
  • Application of Acellular Xenograft In the case of an acellular xenograft, the implant sheet is cut to the appropriate size and shape of the wound, applied to the prepared wound bed, and secured with sutures to maintain its position.
  • Dressing Application After the skin substitute has been applied, a layered dressing is placed over the graft. This dressing typically includes a nonadherent layer, a bulky layer of gauze, a compression layer, and an anti-shear layer to protect the graft and promote healing.

3. Post-Procedure

Post-procedure care following the application of a skin substitute graft involves monitoring the graft site for signs of infection, ensuring that the dressing remains intact, and providing instructions for wound care. Patients may be advised to avoid excessive movement of the affected area to promote healing and prevent dislodgment of the graft. Follow-up appointments are essential to assess the healing process and determine if additional interventions are necessary. The expected recovery time may vary based on the size and location of the wound, as well as the patient's overall health and adherence to post-procedure care instructions.

Short Descr SKN SUB GRFT F/N/HF/G CH ADD
Medium Descr SUB GRFT F/S/N/H/F/G/M/D >= 100SCM ADL 100SQ CM
Long Descr Application of skin substitute graft to face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits, total wound surface area greater than or equal to 100 sq cm; each additional 100 sq cm wound surface area, or part thereof, or each additional 1% of body area of infants and children, or part thereof (List separately in addition to code for primary procedure)
Status Code Active Code
Global Days ZZZ - Code Related to Another Service
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 1 - Co-surgeons could be paid, though supporting documentation is required...
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
ASC Payment Indicator Packaged service/item; no separate payment made.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P5A - Ambulatory procedures - skin
MUE 15
CCS Clinical Classification 172 - Skin graft

This is an add-on code that must be used in conjunction with one of these primary codes.

15277 MPFS Status: Active Code APC T ASC G2 Application of skin substitute graft to face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits, total wound surface area greater than or equal to 100 sq cm; first 100 sq cm wound surface area, or 1% of body area of infants and children
GC This service has been performed in part by a resident under the direction of a teaching physician
GW Service not related to the hospice patient's terminal condition
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
CR Catastrophe/disaster related
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
RT Right side (used to identify procedures performed on the right side of the body)
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
80 Assistant surgeon: surgical assistant services may be identified by adding modifier 80 to the usual procedure number(s).
82 Assistant surgeon (when qualified resident surgeon not available): the unavailability of a qualified resident surgeon is a prerequisite for use of modifier 82 appended to the usual procedure code number(s).
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
F1 Left hand, second digit
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GZ Item or service expected to be denied as not reasonable and necessary
KX Requirements specified in the medical policy have been met
LT Left side (used to identify procedures performed on the left side of the body)
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
XP Separate practitioner, a service that is distinct because it was performed by a different practitioner
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
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2013-01-01 Changed Medium Descriptor changed.
2012-01-01 Added Added
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