CPT® Code 38214

1. Indications

The procedure associated with CPT® Code 38214 is indicated for the preparation of hematopoietic progenitor cells that have been previously harvested for transplantation. This preparation is essential in scenarios where there is a need to enhance the concentration of these cells prior to their infusion into a patient. The specific indications for this procedure include:

• Transplantation Preparation: The procedure is performed to prepare hematopoietic progenitor cells for transplantation, ensuring that the cells are in an optimal state for infusion.
• Volume Reduction: It is indicated when there is a need to reduce the volume of the harvested cell collection by removing plasma, thereby concentrating the hematopoietic progenitor cells for better therapeutic efficacy.

2. Procedure

The procedure for CPT® Code 38214 involves several critical steps to ensure the effective preparation of hematopoietic progenitor cells. These steps include:

• Step 1: Thawing of Cells The harvested hematopoietic progenitor cells, which have been preserved in a cryoprotectant solution, are carefully thawed. This process is conducted under controlled conditions to prevent damage to the cells, ensuring their viability for subsequent procedures.
• Step 2: Plasma Depletion Following thawing, the next step involves the removal of plasma from the cell collection. This is achieved through specific techniques that allow for the separation of plasma from the concentrated hematopoietic progenitor cells. The goal is to reduce the overall volume of the cell preparation while retaining the necessary cellular components for effective transplantation.
• Step 3: Preparation for Infusion After plasma depletion, the concentrated hematopoietic progenitor cells are prepared for infusion. This may involve additional processing steps to ensure that the cells are in the best possible condition for administration to the recipient.

3. Post-Procedure

Post-procedure care following the preparation of hematopoietic progenitor cells involves monitoring the cells for viability and ensuring that they are ready for infusion. It is essential to maintain appropriate storage conditions until the cells are administered to the patient. Additionally, healthcare professionals must ensure that all documentation related to the preparation process is complete and accurate, as this is critical for compliance and reimbursement purposes. The expected recovery from the procedure itself is typically not applicable, as this is a preparatory step rather than a surgical intervention. However, the overall success of the transplantation will depend on the quality of the prepared cells and the subsequent care provided to the patient during and after the infusion process.