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Official Description

Magnetic resonance spectroscopy

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

Magnetic resonance spectroscopy (MRS), also known as nuclear magnetic resonance (NMR) spectroscopy, is a specialized imaging technique that utilizes a standard magnetic resonance imaging (MRI) machine. This procedure employs advanced software to acquire and mathematically manipulate data, resulting in the creation of a spectrum or graph that illustrates the chemical metabolites present within body tissues. The metabolites that are typically analyzed during MRS include lipids, lactate, N-acetylaspartate (NAA), glutamate and glutamine, creatine, choline, and myo-inositol. MRS serves a critical role in the medical field, particularly in the diagnosis, treatment, and ongoing monitoring of various conditions. These conditions include brain tumors, dementia, hypoxic encephalopathy, stroke, head injury, epilepsy, metabolic brain disorders, movement disorders, psychiatric conditions, as well as tumors of the breast and prostate gland. By providing detailed information about the chemical composition of tissues, MRS aids healthcare professionals in making informed decisions regarding patient care and management.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

Magnetic resonance spectroscopy (MRS) is indicated for a variety of medical conditions, particularly those affecting the brain and certain tumors. The following are the explicitly provided indications for performing MRS:

  • Brain Tumors MRS is utilized to assist in the diagnosis and treatment planning for patients with brain tumors.
  • Dementia The procedure aids in the evaluation of metabolic changes associated with dementia.
  • Hypoxic Encephalopathy MRS can help assess brain tissue metabolism in cases of hypoxic encephalopathy.
  • Stroke The technique is used to monitor metabolic changes following a stroke.
  • Head Injury MRS assists in evaluating the biochemical status of brain tissue after a head injury.
  • Epilepsy The procedure is indicated for assessing metabolic abnormalities in patients with epilepsy.
  • Metabolic Brain Disorders MRS is used to diagnose and monitor various metabolic brain disorders.
  • Movement Disorders The technique can provide insights into the metabolic processes involved in movement disorders.
  • Psychiatric Conditions MRS may be employed to study metabolic changes in patients with psychiatric conditions.
  • Breast Cancer The procedure is indicated for evaluating metabolic activity in breast cancer.
  • Prostate Gland Tumors MRS is used to assess metabolic changes associated with prostate gland tumors.

2. Procedure

The procedure for magnetic resonance spectroscopy (MRS) involves several key steps that ensure accurate data acquisition and analysis. The following outlines the procedural steps:

  • Step 1: Patient Preparation Prior to the MRS procedure, the patient is prepared by explaining the process and ensuring they are comfortable. Any contraindications to MRI, such as the presence of metal implants, are assessed. The patient may be asked to remove any jewelry or clothing with metal components.
  • Step 2: Positioning The patient is positioned on the MRI table, typically in a supine position. Proper positioning is crucial to ensure that the area of interest is centered within the magnetic field of the MRI machine.
  • Step 3: Imaging Setup The MRI machine is calibrated, and the appropriate sequences for MRS are selected. This includes setting the parameters for data acquisition, such as the echo time and repetition time, which are essential for obtaining high-quality spectra.
  • Step 4: Data Acquisition The MRS data is acquired while the patient remains still. The MRI machine generates radiofrequency pulses that excite the protons in the metabolites of interest. The emitted signals are then collected and processed to create a spectrum.
  • Step 5: Data Analysis After data acquisition, the collected signals are mathematically manipulated using specialized software to produce a spectrum that displays the concentration of various metabolites. This analysis is crucial for interpreting the biochemical status of the tissue.
  • Step 6: Reporting The results of the MRS are compiled into a report that details the findings, including the levels of specific metabolites. This report is then provided to the referring physician for further evaluation and management of the patient.

3. Post-Procedure

After the magnetic resonance spectroscopy (MRS) procedure, patients are typically monitored for a short period to ensure there are no immediate adverse effects from the MRI. Since MRS is a non-invasive procedure, there is generally no recovery time required. Patients can usually resume their normal activities immediately following the procedure. The results of the MRS will be reviewed by the healthcare provider, who will discuss the findings with the patient and determine any necessary follow-up actions or treatments based on the metabolic information obtained from the spectroscopy.

Short Descr MR SPECTROSCOPY
Medium Descr MRI SPECTROSCOPY
Long Descr Magnetic resonance spectroscopy
Status Code Carriers Price the Code
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 1 - Diagnostic Tests for Radiology Services
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Not Discounted when Multiple
ASC Payment Indicator Radiology service paid separately when provided integral to a surgical procedure on ASC list; payment based on OPPS relative payment weight.
Type of Service (TOS) 4 - Diagnostic Radiology
Berenson-Eggers TOS (BETOS) I2D - Advanced imaging - MRI/MRA: other
MUE 1
CCS Clinical Classification 226 - Other diagnostic radiology and related techniques

This is a primary code that can be used with these additional add-on codes.

0698T Add-on Code Resequenced Code MPFS Status: Carrier Priced APC S ASC Z2 Quantitative magnetic resonance for analysis of tissue composition (eg, fat, iron, water content), including multiparametric data acquisition, data preparation and transmission, interpretation and report, obtained with diagnostic MRI examination of the same anatomy (eg, organ, gland, tissue, target structure); multiple organs (List separately in addition to code for primary procedure)
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
MG The order for this service does not have applicable appropriate use criteria in the qualified clinical decision support mechanism consulted by the ordering professional
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
GC This service has been performed in part by a resident under the direction of a teaching physician
MH Unknown if ordering professional consulted a clinical decision support mechanism for this service, related information was not provided to the furnishing professional or provider
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
CR Catastrophe/disaster related
GA Waiver of liability statement issued as required by payer policy, individual case
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
GZ Item or service expected to be denied as not reasonable and necessary
LT Left side (used to identify procedures performed on the left side of the body)
MA Ordering professional is not required to consult a clinical decision support mechanism due to service being rendered to a patient with a suspected or confirmed emergency medical condition
MC Ordering professional is not required to consult a clinical decision support mechanism due to the significant hardship exception of electronic health record or clinical decision support mechanism vendor issues
ME The order for this service adheres to appropriate use criteria in the clinical decision support mechanism consulted by the ordering professional
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
TC Technical component; under certain circumstances, a charge may be made for the technical component alone; under those circumstances the technical component charge is identified by adding modifier 'tc' to the usual procedure number; technical component charges are institutional charges and not billed separately by physicians; however, portable x-ray suppliers only bill for technical component and should utilize modifier tc; the charge data from portable x-ray suppliers will then be used to build customary and prevailing profiles
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
Date
Action
Notes
2021-01-01 Note Guidelines changed.
1998-01-01 Added First appearance in code book in 1998.
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