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Official Description

Radiopharmaceutical quantification measurement(s) single area (List separately in addition to code for primary procedure)

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 78835 refers to the process of radiopharmaceutical quantification measurement(s) for a single area, which is reported separately in addition to the code for the primary procedure. This code is utilized in conjunction with previously acquired SPECT-CT imaging data, specifically codes 78830 and 78832. The purpose of this quantification is to provide a more detailed analysis beyond mere visual inspection of the images, particularly in assessing the extent of therapeutic uptake or response in cases involving malignant or metastatic lesions. This detailed quantification aids healthcare professionals in determining the appropriate course of treatment or prognosis for the patient.

In the context of SPECT-CT imaging, the initial imaging is performed in three-dimensional format and in list mode, which captures the raw, unreconstructed detector signal output. This method allows for a more accurate quantification process. The acquired data is then filed for quantitation and exported to a dedicated computer system. Following the standard SPECT-CT image processing, additional processing is conducted using specialized software designed for quantitation. This processed data is subsequently imported into a quality control software program for thorough analysis. The physician is provided with both the processed dataset and its quality information for review, which includes critical metrics such as bolus duration, peak and plateau waveforms, and tumor uptake within a specified time interval post-administration. Ultimately, the quantitation data is integrated with the imaging data, attenuation values, and relevant clinical information to generate a comprehensive report for clinical decision-making.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The indications for performing radiopharmaceutical quantification measurement(s) using CPT® Code 78835 include the following:

  • Assessment of Therapeutic Uptake This procedure is indicated for evaluating the extent of therapeutic uptake in patients with malignant or metastatic lesions, providing critical information for treatment planning.
  • Response Evaluation It is utilized to assess the response of tumors to therapy, allowing for a more informed decision regarding the continuation or modification of treatment protocols.
  • Prognostic Evaluation The quantification data aids in determining the prognosis of the patient by offering insights into the behavior of the lesions over time.

2. Procedure

The procedure for radiopharmaceutical quantification measurement(s) involves several detailed steps:

  • Step 1: Initial SPECT-CT Imaging The process begins with the acquisition of SPECT-CT imaging for the target area in a three-dimensional format. This imaging is performed in list mode, capturing the raw, unreconstructed detector signal output, which is essential for subsequent quantification.
  • Step 2: Data Filing and Export After the imaging is completed, the acquired data is filed specifically for quantitation purposes. This data is then exported to a dedicated computer system that is equipped to handle the quantification process.
  • Step 3: Standard Image Processing The standard SPECT-CT image processing is conducted to prepare the data for further analysis. This step ensures that the images are appropriately formatted and ready for the next phase of quantitation.
  • Step 4: Additional Processing for Quantitation Following the standard processing, additional processing is performed using a separate software program specifically designed for quantitation. This step is crucial for extracting the necessary quantitative data from the imaging results.
  • Step 5: Quality Control Analysis The processed data is imported into a quality control software program for comprehensive analysis. This program evaluates various quality control metrics, including bolus duration, peak and plateau waveforms, and tumor uptake within a defined time interval after the administration of the radiopharmaceutical.
  • Step 6: Physician Review The physician receives both the processed dataset and the quality control information for review. This review includes an assessment of the quantitation data alongside the imaging data, attenuation values, and relevant clinical information.
  • Step 7: Report Generation Finally, the quantitation data is integrated with the imaging data and clinical information to generate a comprehensive report. This report is essential for guiding clinical decisions regarding the patient's treatment plan.

3. Post-Procedure

Post-procedure care following the radiopharmaceutical quantification measurement(s) involves monitoring the patient for any immediate reactions to the radiopharmaceutical administered. The physician will review the generated report, which includes the quantitation data and imaging results, to determine the next steps in the patient's treatment plan. Follow-up appointments may be scheduled to discuss the findings and any necessary adjustments to the treatment regimen based on the quantification results. Additionally, the physician may provide the patient with information regarding any further imaging studies or therapeutic interventions that may be required based on the analysis of the quantitation data.

Short Descr RP QUAN MEAS SINGLE AREA
Medium Descr RADIOPHARMACEUTICAL QUANTIFICATION MEAS 1 AREA
Long Descr Radiopharmaceutical quantification measurement(s) single area (List separately in addition to code for primary procedure)
Status Code Active Code
Global Days ZZZ - Code Related to Another Service
PC/TC Indicator (26, TC) 1 - Diagnostic Tests for Radiology Services
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
ASC Payment Indicator Packaged service/item; no separate payment made.
Type of Service (TOS) 4 - Diagnostic Radiology
Berenson-Eggers TOS (BETOS) none
MUE 2

This is an add-on code that must be used in conjunction with one of these primary codes.

78830 Resequenced Code MPFS Status: Active Code APC S ASC Z2 Radiopharmaceutical localization of tumor, inflammatory process or distribution of radiopharmaceutical agent(s) (includes vascular flow and blood pool imaging, when performed); tomographic (SPECT) with concurrently acquired computed tomography (CT) transmission scan for anatomical review, localization and determination/detection of pathology, single area (eg, head, neck, chest, pelvis) or acquisition, single day imaging
78832 Resequenced Code MPFS Status: Active Code APC S ASC Z2 Radiopharmaceutical localization of tumor, inflammatory process or distribution of radiopharmaceutical agent(s) (includes vascular flow and blood pool imaging, when performed); tomographic (SPECT) with concurrently acquired computed tomography (CT) transmission scan for anatomical review, localization and determination/detection of pathology, minimum 2 areas (eg, pelvis and knees, chest and abdomen) or separate acquisitions (eg, lung ventilation and perfusion), single day imaging, or single area or acquisition over 2 or more days
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
GC This service has been performed in part by a resident under the direction of a teaching physician
ME The order for this service adheres to appropriate use criteria in the clinical decision support mechanism consulted by the ordering professional
MG The order for this service does not have applicable appropriate use criteria in the qualified clinical decision support mechanism consulted by the ordering professional
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
GZ Item or service expected to be denied as not reasonable and necessary
MF The order for this service does not adhere to the appropriate use criteria in the clinical decision support mechanism consulted by the ordering professional
MH Unknown if ordering professional consulted a clinical decision support mechanism for this service, related information was not provided to the furnishing professional or provider
PD Diagnostic or related non diagnostic item or service provided in a wholly owned or operated entity to a patient who is admitted as an inpatient within 3 days
QQ Ordering professional consulted a qualified clinical decision support mechanism for this service and the related data was provided to the furnishing professional
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
Date
Action
Notes
2020-01-01 Added Code added.
Code
Description
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