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Official Description

Radiopharmaceutical localization of tumor, inflammatory process or distribution of radiopharmaceutical agent(s) (includes vascular flow and blood pool imaging, when performed); tomographic (SPECT) with concurrently acquired computed tomography (CT) transmission scan for anatomical review, localization and determination/detection of pathology, single area (eg, head, neck, chest, pelvis) or acquisition, single day imaging

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 78830 refers to a specialized imaging procedure known as radiopharmaceutical localization, which is utilized for identifying tumors or inflammatory processes within the body. This procedure employs molecular imaging techniques, specifically single photon emission computed tomography (SPECT), in conjunction with a computed tomography (CT) scan that is acquired simultaneously. The use of a radiolabeled isotope tracer is central to this process, as it allows for the precise localization of pathological conditions, including tumors and areas of inflammation. The radiopharmaceutical agent is designed to bind to specific tissues, enabling the detection of abnormalities even in their early stages. During the procedure, an intravenous line is established to facilitate the injection of the radiolabeled isotope tracer directly into the patient's circulatory system. Alternatively, a blood sample may be taken, processed to isolate certain blood cells, and then tagged with the isotope before being reintroduced into the patient. In some cases, radioactive agents may also be administered through inhalation or ingestion. Once the tracer is in the body, it circulates and accumulates in areas of interest, such as inflamed or tumorous tissues. The imaging process involves positioning the patient on a specialized imaging table, where a gamma camera, capable of performing both SPECT and CT scans, is aligned over the targeted area. The scanning occurs at predetermined intervals, capturing the radioactive energy emitted from the tracer, which is then converted into detailed images. This hybrid imaging technique not only provides a three-dimensional view of the area under investigation but also allows for anatomical review and localization of any detected pathology. The entire procedure is typically completed in a single day, focusing on one specific area of the body, such as the head, neck, chest, or pelvis. Following the imaging, the physician interprets the results and generates a comprehensive written report detailing the findings.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The procedure associated with CPT® Code 78830 is indicated for the localization of tumors or inflammatory processes within the body. It is particularly useful in the following scenarios:

  • Detection of Tumors This procedure is performed to identify the presence of tumors, which may be benign or malignant, allowing for early diagnosis and treatment planning.
  • Assessment of Inflammatory Processes It is utilized to localize areas of inflammation, which can be critical in diagnosing conditions such as infections or autoimmune disorders.
  • Evaluation of Radiopharmaceutical Distribution The procedure helps in assessing the distribution of radiopharmaceutical agents, which is essential for understanding the physiological function of specific organs or tissues.

2. Procedure

The procedure for CPT® Code 78830 involves several key steps that ensure accurate imaging and localization of the targeted area. The following outlines the procedural steps:

  • Step 1: Preparation and Injection Initially, the patient is prepared for the procedure by establishing an intravenous line. A radiolabeled isotope tracer is then injected directly into the patient's circulatory system. Alternatively, a blood sample may be drawn, and specific blood cells can be tagged with the isotope before being reintroduced into the patient. This step is crucial as it allows the tracer to circulate and bind to areas of interest within the body.
  • Step 2: Imaging Setup Once the tracer has been administered, the patient is positioned on the imaging table. A specialized gamma camera, capable of performing both SPECT and CT scans, is centered over the area that requires examination. This setup is essential for capturing the necessary images for analysis.
  • Step 3: Scanning Process The scanning process begins, during which the gamma camera captures images at specific intervals. The radioactive energy emitted from the tracer is detected and converted into images. This step may include blood pool imaging, which visualizes the flow of the radioactive tracer through the target area, providing additional diagnostic information.
  • Step 4: Image Acquisition and Analysis The imaging procedure results in the generation of detailed images that may be produced through hybridized imaging techniques, combining SPECT and CT data. These images allow for anatomical review and localization of any detected pathology.
  • Step 5: Interpretation and Reporting After the imaging is complete, the physician interprets the results and compiles a written report detailing the findings. This report is essential for guiding further clinical decisions and treatment options.

3. Post-Procedure

Post-procedure care for patients undergoing CPT® Code 78830 typically involves monitoring for any immediate reactions to the radiopharmaceutical agent. Patients may be advised to drink plenty of fluids to help flush the radioactive material from their system. Additionally, the physician will review the imaging results and discuss the findings with the patient, outlining any necessary follow-up actions or additional diagnostic procedures that may be required based on the results of the imaging study.

Short Descr RP LOCLZJ TUM SPECT W/CT 1
Medium Descr RP LOCLZJ TUM SPECT W/CT 1 AREA/ACQUISJ 1DAY IMG
Long Descr Radiopharmaceutical localization of tumor, inflammatory process or distribution of radiopharmaceutical agent(s) (includes vascular flow and blood pool imaging, when performed); tomographic (SPECT) with concurrently acquired computed tomography (CT) transmission scan for anatomical review, localization and determination/detection of pathology, single area (eg, head, neck, chest, pelvis) or acquisition, single day imaging
Status Code Active Code
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 1 - Diagnostic Tests for Radiology Services
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Not Discounted when Multiple
ASC Payment Indicator Radiology service paid separately when provided integral to a surgical procedure on ASC list; payment based on OPPS relative payment weight.
Type of Service (TOS) 4 - Diagnostic Radiology
Berenson-Eggers TOS (BETOS) none
MUE 1

This is a primary code that can be used with these additional add-on codes.

78835 Add-on Code Resequenced Code MPFS Status: Active Code APC N ASC N1 Radiopharmaceutical quantification measurement(s) single area (List separately in addition to code for primary procedure)
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
GC This service has been performed in part by a resident under the direction of a teaching physician
MG The order for this service does not have applicable appropriate use criteria in the qualified clinical decision support mechanism consulted by the ordering professional
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
ME The order for this service adheres to appropriate use criteria in the clinical decision support mechanism consulted by the ordering professional
MH Unknown if ordering professional consulted a clinical decision support mechanism for this service, related information was not provided to the furnishing professional or provider
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
QQ Ordering professional consulted a qualified clinical decision support mechanism for this service and the related data was provided to the furnishing professional
TC Technical component; under certain circumstances, a charge may be made for the technical component alone; under those circumstances the technical component charge is identified by adding modifier 'tc' to the usual procedure number; technical component charges are institutional charges and not billed separately by physicians; however, portable x-ray suppliers only bill for technical component and should utilize modifier tc; the charge data from portable x-ray suppliers will then be used to build customary and prevailing profiles
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
MF The order for this service does not adhere to the appropriate use criteria in the clinical decision support mechanism consulted by the ordering professional
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
CR Catastrophe/disaster related
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
FY X-ray taken using computed radiography technology/cassette-based imaging
GA Waiver of liability statement issued as required by payer policy, individual case
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
GZ Item or service expected to be denied as not reasonable and necessary
LT Left side (used to identify procedures performed on the left side of the body)
MA Ordering professional is not required to consult a clinical decision support mechanism due to service being rendered to a patient with a suspected or confirmed emergency medical condition
MC Ordering professional is not required to consult a clinical decision support mechanism due to the significant hardship exception of electronic health record or clinical decision support mechanism vendor issues
MD Ordering professional is not required to consult a clinical decision support mechanism due to the significant hardship exception of extreme and uncontrollable circumstances
PD Diagnostic or related non diagnostic item or service provided in a wholly owned or operated entity to a patient who is admitted as an inpatient within 3 days
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
XP Separate practitioner, a service that is distinct because it was performed by a different practitioner
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
Date
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Notes
2023-01-01 Changed Code description changed.
2020-01-01 Added Code added.
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