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Official Description

Radiopharmaceutical localization of tumor, inflammatory process or distribution of radiopharmaceutical agent(s) (includes vascular flow and blood pool imaging, when performed); tomographic (SPECT), single area (eg, head, neck, chest, pelvis) or acquisition, single day imaging

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 78803 refers to a diagnostic imaging procedure known as radiopharmaceutical localization, which utilizes molecular imaging techniques, specifically single photon emission computed tomography (SPECT). This procedure is designed to identify and localize tumors or inflammatory processes within the body by employing a radiolabeled isotope tracer. The tracer is engineered to bind to specific cells or tissues, allowing for the detection of inflammation or neoplastic growths, even in their early stages. The process begins with the establishment of an intravenous line, through which the radiolabeled isotope is injected directly into the patient's circulatory system. Alternatively, a blood sample may be taken, and the white or red blood cells can be separated and tagged with the isotope before being reintroduced into the patient. In some cases, radioactive agents may also be inhaled or ingested to facilitate distribution throughout the body. Once administered, the tracer circulates and localizes in areas of interest, such as inflamed or tumorous tissues. The patient is then positioned on an imaging table, and a specialized gamma camera is used to capture images of the targeted area, rotating around the patient to obtain comprehensive views. This imaging technique can include blood pool imaging, which visualizes the flow of the radioactive tracer through the area of interest. The resulting images provide valuable insights into the size, volume, and physiological processes of the target tissue. Ultimately, the physician interprets the findings from the SPECT imaging and generates a detailed written report, contributing to the overall diagnostic process.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The procedure associated with CPT® Code 78803 is indicated for the localization of tumors or inflammatory processes within the body. It is particularly useful in the following scenarios:

  • Detection of Tumors This procedure is performed to identify the presence of tumors, which may be benign or malignant, allowing for early diagnosis and intervention.
  • Assessment of Inflammatory Processes It is utilized to localize areas of inflammation, which can be indicative of various medical conditions, including infections or autoimmune disorders.
  • Evaluation of Treatment Response The imaging can help assess the effectiveness of ongoing treatments for cancer or inflammatory diseases by visualizing changes in the targeted tissues.

2. Procedure

The procedure for CPT® Code 78803 involves several key steps that ensure accurate localization of the tumor or inflammatory process:

  • Establishment of Intravenous Access An intravenous line is established to facilitate the administration of the radiolabeled isotope tracer directly into the patient's circulatory system. This step is crucial for ensuring that the tracer is delivered effectively.
  • Administration of Radiopharmaceutical Agent The radiolabeled isotope tracer is injected into the bloodstream. In some cases, a blood sample may be drawn, and the white or red blood cells are separated, tagged with the isotope, and then re-injected into the patient. This method allows for targeted imaging based on the physiological function of the cells.
  • Positioning of the Patient The patient is positioned on the imaging table, ensuring that the area of interest is accessible for imaging. Proper positioning is essential for obtaining clear and accurate images.
  • Imaging with Gamma Camera A specialized gamma camera is centered over the area to be studied. The camera rotates around the patient, typically at angles of 180 or 360 degrees, capturing images at specific intervals and multiple positions. This comprehensive scanning technique allows for detailed visualization of the targeted tissues.
  • Image Acquisition and Interpretation The emitted radioactive energy from the tracer is converted into images, which may include blood pool imaging to visualize the flow of the tracer. The physician then interprets these images and compiles a written report detailing the findings, which aids in diagnosis and treatment planning.

3. Post-Procedure

After the completion of the imaging procedure, patients may be monitored for any immediate reactions to the radiopharmaceutical agent. There are typically no specific post-procedure care requirements, but patients may be advised to drink plenty of fluids to help flush the radioactive material from their system. The results of the imaging study will be reviewed by the physician, who will provide a detailed report outlining the findings and any necessary follow-up actions based on the results. Patients should be informed about when to expect the report and any further steps that may be required depending on the findings of the imaging study.

Short Descr RP LOCLZJ TUM SPECT 1 AREA
Medium Descr RP LOCLZJ TUM SPECT 1 AREA/ACQUISJ 1 DAY IMG
Long Descr Radiopharmaceutical localization of tumor, inflammatory process or distribution of radiopharmaceutical agent(s) (includes vascular flow and blood pool imaging, when performed); tomographic (SPECT), single area (eg, head, neck, chest, pelvis) or acquisition, single day imaging
Status Code Active Code
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 1 - Diagnostic Tests for Radiology Services
Multiple Procedures (51) 4 - Special payment adjustment rules on the technical component (TC) of multiple diagnostic imaging procedures apply...
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 88 -
APC Status Indicator Procedure or Service, Not Discounted when Multiple
ASC Payment Indicator Radiology service paid separately when provided integral to a surgical procedure on ASC list; payment based on OPPS relative payment weight.
Type of Service (TOS) 4 - Diagnostic Radiology
Berenson-Eggers TOS (BETOS) I1E - Standard imaging - nuclear medicine
MUE 1
CCS Clinical Classification 209 - Radioisotope scan and function studies
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
GC This service has been performed in part by a resident under the direction of a teaching physician
MG The order for this service does not have applicable appropriate use criteria in the qualified clinical decision support mechanism consulted by the ordering professional
MH Unknown if ordering professional consulted a clinical decision support mechanism for this service, related information was not provided to the furnishing professional or provider
TC Technical component; under certain circumstances, a charge may be made for the technical component alone; under those circumstances the technical component charge is identified by adding modifier 'tc' to the usual procedure number; technical component charges are institutional charges and not billed separately by physicians; however, portable x-ray suppliers only bill for technical component and should utilize modifier tc; the charge data from portable x-ray suppliers will then be used to build customary and prevailing profiles
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
ME The order for this service adheres to appropriate use criteria in the clinical decision support mechanism consulted by the ordering professional
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
QQ Ordering professional consulted a qualified clinical decision support mechanism for this service and the related data was provided to the furnishing professional
MF The order for this service does not adhere to the appropriate use criteria in the clinical decision support mechanism consulted by the ordering professional
GA Waiver of liability statement issued as required by payer policy, individual case
MC Ordering professional is not required to consult a clinical decision support mechanism due to the significant hardship exception of electronic health record or clinical decision support mechanism vendor issues
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
CR Catastrophe/disaster related
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
GZ Item or service expected to be denied as not reasonable and necessary
JZ Zero drug amount discarded/not administered to any patient
LT Left side (used to identify procedures performed on the left side of the body)
MA Ordering professional is not required to consult a clinical decision support mechanism due to service being rendered to a patient with a suspected or confirmed emergency medical condition
MB Ordering professional is not required to consult a clinical decision support mechanism due to the significant hardship exception of insufficient internet access
PD Diagnostic or related non diagnostic item or service provided in a wholly owned or operated entity to a patient who is admitted as an inpatient within 3 days
Q0 Investigational clinical service provided in a clinical research study that is in an approved clinical research study
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
Q5 Service furnished under a reciprocal billing arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
RT Right side (used to identify procedures performed on the right side of the body)
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
XP Separate practitioner, a service that is distinct because it was performed by a different practitioner
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Notes
2023-01-01 Changed Medium and Long descriptions changed.
2020-01-01 Changed Code description changed.
2004-01-01 Changed Code description changed.
Pre-1990 Added Code added.
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