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Official Description

Radiopharmaceutical localization of tumor, inflammatory process or distribution of radiopharmaceutical agent(s) (includes vascular flow and blood pool imaging, when performed); planar, single area (eg, head, neck, chest, pelvis), single day imaging

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 78800 refers to a diagnostic procedure known as radiopharmaceutical localization, which is utilized to identify tumors or inflammatory processes within the body. This procedure employs molecular imaging techniques, specifically scintigraphy, which involves the use of a radiolabeled isotope tracer. The primary purpose of this imaging is to detect the presence of inflammation or tumors, even in their early stages, by observing the distribution of these radiopharmaceutical agents in the body. The isotope tracer is designed to bind to specific cells, such as those involved in inflammatory responses, or to target particular organs based on their physiological functions. To initiate the procedure, an intravenous line is established, allowing for the direct injection of the radiolabeled isotope tracer into the patient's circulatory system. Alternatively, a blood sample may be drawn, processed to separate the white or red blood cells, and then tagged with the isotope tracer before being reintroduced into the patient. In some cases, radioactive agents may also be administered through inhalation or ingestion, depending on the specific requirements of the imaging study. Once the tracer is in the body, it circulates and localizes in areas of tumorous or inflamed tissue. The patient is then positioned on an imaging table, and a gamma camera is centered over the targeted area for examination. Scanning is conducted at predetermined intervals, capturing the radioactive energy emitted from the tracer, which is subsequently converted into images. This imaging may include blood pool imaging, which visualizes the flow of the radioactive tracer through the area of interest. The CPT® Code 78800 specifically applies to planar imaging of a single area, such as the head, neck, chest, or pelvis, conducted on a single day. For imaging of multiple areas or over multiple days, different CPT codes are applicable, such as 78801 and 78802. The physician is responsible for interpreting the results of the study and providing a comprehensive written report detailing the findings.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The CPT® Code 78800 is indicated for use in various clinical scenarios where localization of tumors or inflammatory processes is necessary. The following conditions may warrant the use of this imaging procedure:

  • Detection of Tumors This procedure is utilized to identify the presence of tumors in various anatomical regions, aiding in the diagnosis and management of cancer.
  • Assessment of Inflammatory Processes It is indicated for evaluating inflammatory conditions, helping to determine the extent and location of inflammation within the body.
  • Monitoring Treatment Response The imaging can be used to assess the effectiveness of ongoing treatment for tumors or inflammatory diseases, providing valuable information on changes in the condition.
  • Preoperative Planning This procedure may assist in surgical planning by accurately localizing tumors or areas of inflammation prior to intervention.

2. Procedure

The procedure associated with CPT® Code 78800 involves several key steps to ensure accurate localization of the target area. The following outlines the procedural steps:

  • Step 1: Establishing Intravenous Access An intravenous line is established to facilitate the administration of the radiolabeled isotope tracer directly into the patient's circulatory system. This step is crucial for ensuring that the tracer is delivered effectively for optimal imaging results.
  • Step 2: Administration of Radiopharmaceutical Agent The radiolabeled isotope tracer is injected into the bloodstream. Alternatively, a blood sample may be drawn, processed to separate the blood cells, and then tagged with the isotope before being reintroduced into the patient. This method allows for targeted imaging based on the biological behavior of the tracer.
  • Step 3: Imaging Procedure After the tracer has been administered, the patient is positioned on the imaging table. A gamma camera is then centered over the area of interest, and scanning is performed at specific intervals. The gamma camera detects the radioactive energy emitted from the tracer, which is then converted into images for analysis.
  • Step 4: Interpretation of Results Following the imaging, the physician interprets the results and compiles a written report detailing the findings. This report is essential for guiding further clinical decision-making and treatment planning.

3. Post-Procedure

After the completion of the imaging procedure associated with CPT® Code 78800, patients may be monitored for any immediate reactions to the radiopharmaceutical agent. There are typically no specific post-procedure care requirements, as the radiotracer used is designed to be safe and is usually eliminated from the body within a short period. Patients may be advised to drink plenty of fluids to help flush the tracer from their system. Additionally, the physician will review the imaging results and discuss any necessary follow-up actions or further diagnostic steps based on the findings. It is important for patients to understand the significance of the results and any implications for their ongoing care.

Short Descr RP LOCLZJ TUM 1 AREA 1 D IMG
Medium Descr RP LOCLZJ TUM PLNR 1 AREA SINGLE DAY IMAGING
Long Descr Radiopharmaceutical localization of tumor, inflammatory process or distribution of radiopharmaceutical agent(s) (includes vascular flow and blood pool imaging, when performed); planar, single area (eg, head, neck, chest, pelvis), single day imaging
Status Code Active Code
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 1 - Diagnostic Tests for Radiology Services
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Not Discounted when Multiple
ASC Payment Indicator Radiology service paid separately when provided integral to a surgical procedure on ASC list; payment based on OPPS relative payment weight.
Type of Service (TOS) 4 - Diagnostic Radiology
Berenson-Eggers TOS (BETOS) I1E - Standard imaging - nuclear medicine
MUE 1
CCS Clinical Classification 209 - Radioisotope scan and function studies
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
MG The order for this service does not have applicable appropriate use criteria in the qualified clinical decision support mechanism consulted by the ordering professional
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
GA Waiver of liability statement issued as required by payer policy, individual case
MH Unknown if ordering professional consulted a clinical decision support mechanism for this service, related information was not provided to the furnishing professional or provider
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
GC This service has been performed in part by a resident under the direction of a teaching physician
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
CR Catastrophe/disaster related
GW Service not related to the hospice patient's terminal condition
LT Left side (used to identify procedures performed on the left side of the body)
MA Ordering professional is not required to consult a clinical decision support mechanism due to service being rendered to a patient with a suspected or confirmed emergency medical condition
MB Ordering professional is not required to consult a clinical decision support mechanism due to the significant hardship exception of insufficient internet access
MC Ordering professional is not required to consult a clinical decision support mechanism due to the significant hardship exception of electronic health record or clinical decision support mechanism vendor issues
ME The order for this service adheres to appropriate use criteria in the clinical decision support mechanism consulted by the ordering professional
MF The order for this service does not adhere to the appropriate use criteria in the clinical decision support mechanism consulted by the ordering professional
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
Q5 Service furnished under a reciprocal billing arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
QQ Ordering professional consulted a qualified clinical decision support mechanism for this service and the related data was provided to the furnishing professional
RT Right side (used to identify procedures performed on the right side of the body)
TC Technical component; under certain circumstances, a charge may be made for the technical component alone; under those circumstances the technical component charge is identified by adding modifier 'tc' to the usual procedure number; technical component charges are institutional charges and not billed separately by physicians; however, portable x-ray suppliers only bill for technical component and should utilize modifier tc; the charge data from portable x-ray suppliers will then be used to build customary and prevailing profiles
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
XP Separate practitioner, a service that is distinct because it was performed by a different practitioner
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
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Notes
2020-01-01 Changed Code description changed.
2011-01-01 Changed Short description changed.
2004-01-01 Changed Code description changed.
Pre-1990 Added Code added.
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