© Copyright 2025 American Medical Association. All rights reserved.
The CPT® Code 83528 refers to a laboratory test specifically designed to measure the level of intrinsic factor (IF) in the body. Intrinsic factor is a crucial glycoprotein that is produced by the parietal cells located in the stomach lining. This protein plays an essential role in the absorption of vitamin B12, also known as cobalamin, within the intestine. The presence and levels of intrinsic factor are vital for maintaining adequate vitamin B12 levels, which are necessary for various bodily functions, including the production of red blood cells and the maintenance of the nervous system. Various medical conditions can affect the production of intrinsic factor, including autoimmune disorders that specifically target either intrinsic factor itself or the parietal cells that produce it. Other factors that may impair intrinsic factor production include atrophic gastritis, which damages the parietal cells, bariatric surgery that alters the stomach's structure, gastric tumors that may interfere with normal cell function, and congenital deficiencies caused by mutations in the GIF gene located on chromosome 11. A deficiency in intrinsic factor can lead to significant health issues, such as megaloblastic anemia, autoimmune pernicious anemia, and in cases of congenital deficiency, it may result in failure to thrive and neurological abnormalities. To assess the levels of intrinsic factor, a gastric aspirate may be tested using the charcoal method of immunoassay, which is a specific laboratory technique employed to detect and quantify the presence of intrinsic factor in the sample.
© Copyright 2025 Coding Ahead. All rights reserved.
The intrinsic factor test (CPT® Code 83528) is indicated for several specific medical conditions and symptoms that may suggest a deficiency or abnormality in intrinsic factor levels. These indications include:
The procedure for measuring intrinsic factor levels involves several key steps, which are outlined as follows:
After the intrinsic factor test is completed, there are generally no specific post-procedure care requirements. Patients may resume their normal activities immediately following the procedure. However, it is essential for healthcare providers to review the test results with the patient to discuss any necessary follow-up actions or further diagnostic evaluations that may be warranted based on the findings. If a deficiency of intrinsic factor is confirmed, appropriate management strategies should be considered to address the underlying condition and prevent complications such as megaloblastic anemia or neurological issues.
| Short Descr | ASSAY OF INTRINSIC FACTOR | Medium Descr | ASSAY OF INTRINSIC FACTOR | Long Descr | Intrinsic factor | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. |
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| 2013-01-01 | Changed | Medium Descriptor changed. |
| Pre-1990 | Added | Code added. |