CPT® Code 85400

1. Indications

The laboratory test associated with CPT® Code 85400 is indicated for various clinical scenarios where the measurement of plasmin activity is necessary. The following conditions may warrant this test:

• Assessment of Fibrinolytic Activity This test is performed to evaluate the fibrinolytic system's functionality, particularly in patients with suspected thrombotic disorders.
• Monitoring of Thrombolytic Therapy It is used to monitor patients undergoing thrombolytic therapy to ensure effective clot dissolution and to assess the risk of bleeding complications.
• Investigation of Coagulation Disorders The test aids in diagnosing and managing patients with coagulation disorders that may involve abnormal plasmin activity.

2. Procedure

The procedure for conducting the test associated with CPT® Code 85400 involves several key steps to ensure accurate measurement of plasmin activity. The following procedural steps are outlined:

• Step 1: Patient Preparation Prior to the test, the patient may be instructed to avoid certain medications or foods that could interfere with the results. It is essential to ensure that the patient is adequately informed about the procedure.
• Step 2: Venipuncture A blood sample is obtained through a venipuncture, which is a separately reportable procedure. The site is cleaned, and a needle is inserted into a vein to collect the blood sample into appropriate collection tubes.
• Step 3: Sample Processing Once the blood sample is collected, it is processed in the laboratory. This may involve centrifugation to separate plasma from blood cells, ensuring that the sample is suitable for testing.
• Step 4: Fluorimetry Testing The plasma sample is then analyzed using fluorimetry, a technique that measures the fluorescence emitted by the plasmin in the sample. This allows for the quantification of plasmin activity.
• Step 5: Result Interpretation After the analysis, the results are interpreted by qualified laboratory personnel, and the findings are reported to the requesting physician for further clinical decision-making.

3. Post-Procedure

After the procedure, patients may experience minor discomfort at the venipuncture site, which typically resolves quickly. There are no specific post-procedure care instructions required for this test, but patients should be advised to monitor the site for any unusual symptoms, such as excessive bleeding or signs of infection. The results of the plasmin activity test will be communicated to the healthcare provider, who will discuss the implications of the findings and any necessary follow-up actions based on the results.