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A laboratory test identified by CPT® Code 85441 is utilized to measure the presence of Heinz bodies, which are aggregates of denatured hemoglobin found within red blood cells (RBCs). These bodies can form as a result of various factors, including damage to hemoglobin caused by oxidizing agents, certain drugs derived from aniline, and specific enzyme deficiency syndromes such as NADPH deficiency, glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, and alpha thalassemia. Additionally, Heinz bodies may be associated with unstable forms of hemoglobin, including Hemoglobin H, Zurich, Koln, Seattle, and Gun Hill variants. The test is particularly relevant in the evaluation of hemolytic anemia, especially in cases where there are deficiencies in RBC enzymes. It may also be part of a diagnostic work-up when 'bite cells' are observed in a routine blood smear. Bite cells are formed when splenic macrophages remove hemoglobin from RBCs, leading to damage of the cell membrane. To perform this test, a blood sample is collected through a separately reportable venipuncture, and the whole blood is subjected to analysis using a Supravital Stain, followed by direct visualization of the cells under a microscope to identify the presence of Heinz bodies.
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The test associated with CPT® Code 85441 is indicated for several specific clinical scenarios, particularly in the context of hemolytic anemia and related conditions. The following indications are explicitly recognized for this laboratory test:
The procedure for conducting the test associated with CPT® Code 85441 involves several key steps that ensure accurate measurement of Heinz bodies in the blood sample. The following procedural steps are outlined:
After the completion of the procedure associated with CPT® Code 85441, there are several considerations for post-procedure care and follow-up. The results of the test will be analyzed and reported, providing critical information regarding the presence of Heinz bodies. If Heinz bodies are detected, further evaluation may be warranted to determine the underlying cause of hemolytic anemia or enzyme deficiencies. Clinicians may need to discuss the results with the patient and consider additional diagnostic tests or treatment options based on the findings. It is also important to monitor the patient for any symptoms related to hemolytic anemia, ensuring appropriate management and care.
| Short Descr | HEINZ BODIES DIRECT | Medium Descr | HEINZ BODIES DIRECT | Long Descr | Heinz bodies; direct | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. |
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| 2011-01-01 | Changed | Short description changed. |
| Pre-1990 | Added | Code added. |
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