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The CPT® Code 85445 refers to a laboratory test specifically designed to measure Heinz bodies, which are denatured hemoglobin structures found within red blood cells (RBCs). Heinz bodies are formed when hemoglobin undergoes damage due to various factors, including exposure to oxidizing agents, certain drugs derived from aniline, and specific enzyme deficiency syndromes such as NADPH deficiency, glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, and alpha thalassemia. Additionally, they may be associated with unstable hemoglobin variants, including hemoglobin H, Zurich, Koln, Seattle, and Gun Hill. This test is particularly useful in the evaluation of hemolytic anemias that are linked to RBC enzyme deficiencies. It may also be part of a diagnostic work-up when 'bite cells' are observed on a routine blood smear. Bite cells are formed when splenic macrophages remove hemoglobin, leading to damage of the RBC membrane. The presence of induced Heinz bodies can provide critical insights into conditions such as oxidative chemical ingestion, G-6-PD deficiency, alpha thalassemia, and certain unstable hemoglobin disorders. To perform this test, a blood sample is collected through a separately reportable venipuncture, after which acetyl phenylhydrazine is added to the whole blood to enhance the production of Heinz bodies. The sample is then examined using Supravital Stain and direct visualization techniques under a microscope to assess the presence of these bodies.
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The test associated with CPT® Code 85445 is indicated for the evaluation of specific conditions and symptoms related to hemolytic anemias and red blood cell (RBC) enzyme deficiencies. The following are the explicitly provided indications for performing this test:
The procedure for conducting the test associated with CPT® Code 85445 involves several key steps that ensure accurate measurement of Heinz bodies in the blood sample. The following procedural steps are outlined:
After the completion of the procedure associated with CPT® Code 85445, there are several considerations for post-procedure care and expected outcomes. The blood sample will be analyzed, and the results will be interpreted by a qualified laboratory professional. The presence of Heinz bodies can provide valuable diagnostic information regarding the patient's condition. It is important for healthcare providers to communicate the results to the patient and discuss any further diagnostic steps or treatments that may be necessary based on the findings. Additionally, no specific post-procedure care is required for the patient following the blood draw, but they should be monitored for any immediate reactions to the venipuncture site.
| Short Descr | HEINZ BODIES INDUCED | Medium Descr | HEINZ BODIES INDUCED ACETYL PHENYLHYDRAZINE | Long Descr | Heinz bodies; induced, acetyl phenylhydrazine | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. |
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| 2011-01-01 | Changed | Short description changed. |
| Pre-1990 | Added | Code added. |
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