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Official Description

Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); concurrent infusion (List separately in addition to code for primary procedure)

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

An intravenous infusion involves the administration of a specified substance or drug directly into a patient's bloodstream through a vein, typically in the arm. This procedure is performed for various purposes, including therapy, prophylaxis, or diagnosis. During the infusion, a healthcare professional, usually a physician, is responsible for the direct supervision of the administration process. This supervision ensures that the physician is immediately available to address any complications that may arise during the procedure. The physician also conducts periodic assessments of the patient's condition and documents the patient's response to the treatment being administered. It is important to note that when coding for intravenous infusions, specific codes are designated for different scenarios: CPT® Code 96365 is used for an intravenous infusion lasting up to one hour, while CPT® Code 96366 is an add-on code for each additional hour of the same infusion. Additionally, CPT® Code 96367 is utilized for another sequential infusion of a different substance or drug for up to one hour. CPT® Code 96368 is specifically designated for situations where a different substance or drug is administered concurrently with another drug, highlighting the complexity and specificity of intravenous infusion coding.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The intravenous infusion procedure is indicated for various clinical scenarios, including but not limited to the following:

  • Therapeutic Use Administration of medications or fluids to treat specific medical conditions or symptoms.
  • Prophylactic Use Infusion of substances to prevent the onset of disease or complications.
  • Diagnostic Use Use of specific substances to assist in the diagnosis of medical conditions.

2. Procedure

The procedure for intravenous infusion involves several key steps that ensure the safe and effective administration of the specified substance or drug.

  • Step 1: Preparation The healthcare provider prepares the necessary equipment, including the intravenous (IV) line, infusion pump, and the specified substance or drug to be administered. This preparation includes verifying the medication, dosage, and patient information to ensure accuracy and safety.
  • Step 2: Venous Access A suitable vein, typically in the patient's arm, is selected for the insertion of the IV catheter. The area is cleaned and sterilized to prevent infection, and the IV catheter is carefully inserted into the vein to establish venous access.
  • Step 3: Administration of Infusion Once the IV line is secured, the specified substance or drug is infused into the patient's bloodstream. The infusion may be continuous or intermittent, depending on the treatment plan. The healthcare provider monitors the infusion rate and adjusts it as necessary to ensure proper delivery of the medication.
  • Step 4: Monitoring Throughout the infusion process, the physician or healthcare provider conducts periodic assessments of the patient's vital signs and overall response to the treatment. This monitoring is crucial for identifying any adverse reactions or complications that may arise during the infusion.
  • Step 5: Documentation After the infusion is completed, the healthcare provider documents the procedure, including the substance or drug administered, the duration of the infusion, the patient's response, and any observations made during the process. This documentation is essential for medical records and billing purposes.

3. Post-Procedure

Post-procedure care involves monitoring the patient for any immediate reactions to the infused substance or drug. The healthcare provider should ensure that the IV site remains clean and free from complications such as infection or phlebitis. Patients may be observed for a specified period to assess their response to the treatment and to manage any potential side effects. Follow-up instructions may be provided based on the specific substance administered and the patient's condition, ensuring that the patient understands any necessary precautions or signs to watch for after the procedure.

Short Descr THER/DIAG CONCURRENT INF
Medium Descr IV NFS THERAPY PROPHYLAXIS/DX CONCURRENT NFS
Long Descr Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); concurrent infusion (List separately in addition to code for primary procedure)
Status Code Active Code
Global Days ZZZ - Code Related to Another Service
PC/TC Indicator (26, TC) 5 - Incident To Code
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
Berenson-Eggers TOS (BETOS) P6C - Minor procedures - other (Medicare fee schedule)
MUE 1
CCS Clinical Classification 231 - Other therapeutic procedures

This is an add-on code that must be used in conjunction with one of these primary codes.

96360 MPFS Status: Active Code APC S CPT Assistant Article 1Intravenous infusion, hydration; initial, 31 minutes to 1 hour
96365 MPFS Status: Active Code APC S CPT Assistant Article Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); initial, up to 1 hour
96366 Addon Code MPFS Status: Active Code APC S CPT Assistant Article Intravenous infusion, for therapy, prophylaxis, or diagnosis (specify substance or drug); each additional hour (List separately in addition to code for primary procedure)
96413 MPFS Status: Active Code APC S Physician Quality Reporting PUB 100 CPT Assistant Article Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
96415 Addon Code MPFS Status: Active Code APC S Physician Quality Reporting PUB 100 CPT Assistant Article Chemotherapy administration, intravenous infusion technique; each additional hour (List separately in addition to code for primary procedure)
96416 MPFS Status: Active Code APC S Physician Quality Reporting PUB 100 CPT Assistant Article Chemotherapy administration, intravenous infusion technique; initiation of prolonged chemotherapy infusion (more than 8 hours), requiring use of a portable or implantable pump
C8957 Medicare Coverage: Special Coverage Instructions APC S Intravenous infusion for therapy/diagnosis; initiation of prolonged infusion (more than 8 hours), requiring use of portable or implantable pump
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
X2 Continuous/focused services: for reporting services by clinicians whose expertise is needed for the ongoing management of a chronic disease or a condition that needs to be managed and followed with no planned endpoint to the relationship; reporting clinician service examples include but are not limited to: a rheumatologist taking care of the patient's rheumatoid arthritis longitudinally but not providing general primary care services
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
CR Catastrophe/disaster related
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
GW Service not related to the hospice patient's terminal condition
25 Significant, separately identifiable evaluation and management service by the same physician or other qualified health care professional on the same day of the procedure or other service: it may be necessary to indicate that on the day a procedure or service identified by a cpt code was performed, the patient's condition required a significant, separately identifiable e/m service above and beyond the other service provided or beyond the usual preoperative and postoperative care associated with the procedure that was performed. a significant, separately identifiable e/m service is defined or substantiated by documentation that satisfies the relevant criteria for the respective e/m service to be reported (see evaluation and management services guidelines for instructions on determining level of e/m service). the e/m service may be prompted by the symptom or condition for which the procedure and/or service was provided. as such, different diagnoses are not required for reporting of the e/m services on the same date. this circumstance may be reported by adding modifier 25 to the appropriate level of e/m service. note: this modifier is not used to report an e/m service that resulted in a decision to perform surgery. see modifier 57 for significant, separately identifiable non-e/m services, see modifier 59.
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
95 Synchronous telemedicine service rendered via a real-time interactive audio and video telecommunications system: synchronous telemedicine service is defined as a real-time interaction between a physician or other qualified health care professional and a patient who is located at a distant site from the physician or other qualified health care professional. the totality of the communication of information exchanged between the physician or other qualified health care professional and the patient during the course of the synchronous telemedicine service must be of an amount and nature that would be sufficient to meet the key components and/or requirements of the same service when rendered via a face-to-face interaction. modifier 95 may only be appended to the services listed in appendix p. appendix p is the list of cpt codes for services that are typically performed face-to-face, but may be rendered via a real-time (synchronous) interactive audio and video telecommunications system.
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
JW Drug amount discarded/not administered to any patient
JZ Zero drug amount discarded/not administered to any patient
KX Requirements specified in the medical policy have been met
PD Diagnostic or related non diagnostic item or service provided in a wholly owned or operated entity to a patient who is admitted as an inpatient within 3 days
Q5 Service furnished under a reciprocal billing arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
SA Nurse practitioner rendering service in collaboration with a physician
Date
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2009-01-01 Added -
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