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Official Description

Digitization of glass microscope slides for morphometric analysis, in situ hybridization (quantitative or semiquantitative), manual, per specimen; initial single probe stain procedure (List separately in addition to code for primary procedure)

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 0851T refers to the process of digitizing glass microscope slides specifically for morphometric analysis and in situ hybridization, which can be either quantitative or semi-quantitative. This procedure involves converting traditional glass slides into a digital format, allowing for the captured images to be stored on a local computer server or within a cloud-based archive. The digitization process enhances the ability to examine the slides remotely, enabling pathologists to analyze the images without being physically present. Additionally, computer algorithms can be employed to assist in providing pathologic diagnoses, which offers a significant advantage over direct visualization through a microscope. The morphometric analysis facilitated by this technique utilizes in situ hybridization, a method that employs fluorescent tagging to visualize specific genes or portions of genes within the sample. Typically, samples such as bone marrow or tumor tissues are prepared manually for analysis, and the digitization of these slides occurs concurrently. It is important to note that CPT® Code 0851T is specifically designated for the initial single probe stain procedure, and additional codes are available for subsequent procedures involving additional single probe stains or multiplex probe stains.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The procedure associated with CPT® Code 0851T is indicated for the following:

  • Morphometric Analysis This procedure is performed to facilitate detailed morphometric analysis of biological specimens, allowing for quantitative or semi-quantitative assessment of cellular structures.
  • In Situ Hybridization It is indicated for the visualization of specific genes or gene segments within tissue samples, which is crucial for genetic analysis and research.
  • Pathological Examination The digitization of slides allows pathologists to conduct remote examinations, enhancing diagnostic capabilities and collaboration among specialists.

2. Procedure

The procedure for CPT® Code 0851T involves several key steps that ensure the effective digitization of glass microscope slides:

  • Preparation of Glass Slides Initially, glass slides containing biological specimens, such as bone marrow or tumor samples, are prepared using manual techniques. This preparation is critical to ensure that the samples are suitable for analysis and that the cellular structures are preserved for accurate examination.
  • Digitization Process Once the slides are prepared, they undergo a digitization process where they are scanned into a digital format. This involves using specialized equipment that captures high-resolution images of the slides, ensuring that all relevant details are preserved for further analysis.
  • Storage of Digital Images After digitization, the captured images are stored either on a local computer server or within a cloud-based archive. This storage solution allows for easy access and management of the images, facilitating remote examination by pathologists and enabling the use of computer algorithms for diagnostic purposes.
  • Application of In Situ Hybridization During the digitization process, in situ hybridization techniques may be applied to visualize specific genes or portions of genes. This step involves the use of fluorescent tagging, which highlights the targeted genetic material within the specimen, providing valuable information for morphometric analysis.

3. Post-Procedure

Post-procedure care for CPT® Code 0851T primarily involves the management and interpretation of the digitized images. Once the slides have been digitized and stored, pathologists can access the images for further examination and analysis. The expected recovery in this context pertains to the ability of healthcare professionals to utilize the digital images for diagnostic purposes without the need for physical slides. Additionally, the integration of these digital images into a growing image-based environment allows for enhanced collaboration and sharing of information among medical professionals. There are no specific post-procedure care requirements for the specimens themselves, as the focus is on the digital analysis and interpretation of the data obtained from the digitized slides.

Short Descr DGTZ GLS MCRSCP MPHMTRC 1ST
Medium Descr DGTZ GLS MCRSCP SLD M/PHMTRC ISH 1ST 1 PROBE STN
Long Descr Digitization of glass microscope slides for morphometric analysis, in situ hybridization (quantitative or semiquantitative), manual, per specimen; initial single probe stain procedure (List separately in addition to code for primary procedure)
Status Code Carriers Price the Code
Global Days ZZZ - Code Related to Another Service
PC/TC Indicator (26, TC) 3 - Technical Component Only Code
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
Berenson-Eggers TOS (BETOS) none
MUE Not applicable/unspecified.

This is an add-on code that must be used in conjunction with one of these primary codes.

88368 MPFS Status: Active Code APC Q2 PUB 100 CPT Assistant Article Morphometric analysis, in situ hybridization (quantitative or semi-quantitative), manual, per specimen; initial single probe stain procedure
Date
Action
Notes
2024-01-01 Added Code Added.
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