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Official Description

Hepatitis B vaccine (HepB), pediatric/adolescent dosage, 3 dose schedule, for intramuscular use

© Copyright 2025 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 90744 refers to the Hepatitis B vaccine (HepB) specifically formulated for pediatric and adolescent patients, administered in a three-dose schedule via intramuscular injection. Vaccines, unlike immune globulins that offer short-term, passive immunity, work by stimulating the recipient's immune system to develop active, long-lasting immunity. This is achieved by introducing altered forms of the hepatitis B virus, prompting the immune system to produce antibodies that will recognize and combat the virus upon future exposure. The hepatitis B vaccine is crucial in providing long-term protection against hepatitis B, a serious liver disease that can lead to severe health complications, including hospitalization and death. Additionally, it plays a significant role in preventing the long-term consequences associated with the disease, such as hepatocellular carcinoma, marking it as one of the pioneering cancer vaccines in medical use. The vaccine can be derived from the blood plasma of asymptomatic carriers or synthesized through recombinant technology, where a plasmid containing the hepatitis gene is inserted into baker's yeast, which is then purified to extract the necessary components. It is important to note that this code specifically reports the hepatitis B vaccine product for intramuscular use, while the actual injection procedure is reported separately. Other related codes include 90739 for adult dosages in a 2-dose or 4-dose schedule, 90740 for dialysis or immunosuppressed patients in a 3-dose schedule, 90743 for an adolescent 2-dose schedule, 90746 for an adult 3-dose schedule, and 90747 for dialysis or immunosuppressed patients in a 4-dose schedule.

© Copyright 2025 Coding Ahead. All rights reserved.

1. Indications

The Hepatitis B vaccine (HepB) is indicated for the prevention of hepatitis B virus infection, particularly in pediatric and adolescent populations. The vaccine is essential for individuals who are at risk of exposure to the virus, which can lead to chronic liver disease, serious health complications, and even death. The following conditions and situations warrant the administration of the Hepatitis B vaccine:

  • Pediatric and Adolescent Patients - The vaccine is specifically formulated for children and adolescents to provide early protection against hepatitis B.
  • Risk of Exposure - Individuals who may be at risk due to potential exposure to the hepatitis B virus, including those in certain healthcare settings or living in areas with high prevalence.
  • Prevention of Chronic Disease - The vaccine is crucial in preventing the long-term consequences of hepatitis B, such as chronic liver disease and hepatocellular carcinoma.

2. Procedure

The administration of the Hepatitis B vaccine (CPT® Code 90744) follows a structured three-dose schedule, which is critical for ensuring effective immunization. The procedural steps are as follows:

  • Step 1: Initial Dose - The first dose of the Hepatitis B vaccine is administered intramuscularly, typically in the deltoid muscle of the upper arm for older children and adolescents, or in the anterolateral thigh for infants and younger children. This initial dose is crucial as it primes the immune system to recognize the hepatitis B virus.
  • Step 2: Second Dose - The second dose is given 1 to 2 months after the first dose. This booster dose enhances the immune response, ensuring that the body produces a sufficient level of antibodies against the virus.
  • Step 3: Third Dose - The final dose is administered 6 months after the first dose. Completing the three-dose series is essential for achieving long-term immunity against hepatitis B, as it solidifies the immune memory and ensures adequate protection.

3. Post-Procedure

After the administration of the Hepatitis B vaccine, patients are typically monitored for a short period to observe for any immediate adverse reactions, although serious side effects are rare. Common post-procedure care includes advising the patient or guardian about potential mild side effects, such as soreness at the injection site, low-grade fever, or fatigue. It is important to inform them that these reactions are generally mild and resolve on their own. Patients should be encouraged to complete the entire three-dose schedule to ensure optimal immunity. Follow-up appointments should be scheduled to administer the subsequent doses as per the recommended timeline.

Short Descr HEPB VACC 3 DOSE PED/ADOL IM
Medium Descr HEPB VACCINE PED/ADOLESC 3 DOSE SCHEDULE IM
Long Descr Hepatitis B vaccine (HepB), pediatric/adolescent dosage, 3 dose schedule, for intramuscular use
Related Drugs ENGERIX-B
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Influenza, Pneumococcal Pneumonia, Hepatitis B, and Covid-19 Vaccines; Monoclonal Antibody Therapy Product
ASC Payment Indicator Corneal tissue acquisition, hepatitis B vaccine; paid at reasonable cost.
Type of Service (TOS) 1 - Medical Care
Berenson-Eggers TOS (BETOS) O1G - Immunizations/Vaccinations
MUE 1
CCS Clinical Classification 228 - Prophylactic vaccinations and inoculations
25 Significant, separately identifiable evaluation and management service by the same physician or other qualified health care professional on the same day of the procedure or other service: it may be necessary to indicate that on the day a procedure or service identified by a cpt code was performed, the patient's condition required a significant, separately identifiable e/m service above and beyond the other service provided or beyond the usual preoperative and postoperative care associated with the procedure that was performed. a significant, separately identifiable e/m service is defined or substantiated by documentation that satisfies the relevant criteria for the respective e/m service to be reported (see evaluation and management services guidelines for instructions on determining level of e/m service). the e/m service may be prompted by the symptom or condition for which the procedure and/or service was provided. as such, different diagnoses are not required for reporting of the e/m services on the same date. this circumstance may be reported by adding modifier 25 to the appropriate level of e/m service. note: this modifier is not used to report an e/m service that resulted in a decision to perform surgery. see modifier 57 for significant, separately identifiable non-e/m services, see modifier 59.
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
GA Waiver of liability statement issued as required by payer policy, individual case
GC This service has been performed in part by a resident under the direction of a teaching physician
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
JZ Zero drug amount discarded/not administered to any patient
SL State supplied vaccine
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2016-01-01 Changed First appearance of change in codebook.
2015-07-01 Changed Description Changed
2001-01-01 Changed Code description changed.
1996-01-01 Added Added
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